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1. WO1987003798 - SYSTEME ELECTROMAGNETIQUE POUR THERAPIE LOCALISEE

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

What is claimed is:

1. A method for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising:
applying a steady or low frequency magnetic field to the patient to include the treatment zone;
supplying microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically inert magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and
applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.

2. A method as defined in claim 1 including the step of adding a radiation emitting material to said microspheres and determining the concentration of said microspheres at different locations within said patient from the output radiation.

3. A method as defined in claim 2 including the additional step of modifying the application of the magnetic field and the high frequency electromagnetic field to increase the concentration of microspheres in the treatment area in accordance with the concentration determination.

4. A method as defined in claim 1 wherein the step of supplying microspheres includes the supplying of microspheres which also include material emitting gamma radiation, and imaging the gamma radiation to ascertain the distribution and concentration of the microspheres .

5. A method as defined in claim 1 wherein the step of supplying microspheres includes the supplying of microspheres material emitting both beta and gamma radiation, whereby the gamma radiation may be used for imaging and the beta rays are employed for their therapeutic value.

6. A method as defined in claim 1 wherein the step of supplying microspheres includes the supplying of microspheres which also include material emitting gamma radiation, technetium 99m, and imaging the gamma radiation to ascertain the distribution and concentration of the microspheres.

7. A method as defined in claim 1 wherein the step of supplying microspheres includes material emitting both beta and gamma radiation, iodine-131, whereby the gamma radiation may be used for imaging and the beta rays are employed for their therapeutic value.

8. A method as defined in claim 1 wherein the application of a high frequency field includes the step of directing high frequency electromagnetic field energy having the same frequency from two different radiating sources, and means for adjusting the relative phase of the radiation for destructive interference or substantial cancellation at the■ reatment zone.

9. A method as defined in claim 1 wherein the magnetic field is applied to the patient from a pre-determined direction adjacent the skin of the patient and wherein said high frequency electromagnetic energy is applied to the patient from substantially the same direction, at an intensity level sufficient to heat the magnetic material toward the adjacent surface of the body but not to heat the magnetic material in the treatment area beyond the Curie point temperature.

10. A method as defined in claim 1 wherein the applying of a high frequency electric field includes the generation of a high frequency electromagnetic field, and the cancellation of magnetic field components adjacent the treatment zone, to provide a sharper delineation of microsphere concentration at the boundaries of said treatment zone.

11. A system for applying a therapeutic agent to a treatment zone in a patient, which treatment zone is not adjacent the skin of the patient, comprising:
means for applying a steady or low frequency magnetic field to the patient to include the treatment zone;
means for supplying- microspheres for circulation through the patient to include said zone, said microspheres including a therapeutic agent, and also includes medically inert magnetic material having a Curie point at which the magnetic material becomes substantially non-magnetic slightly above the normal body temperature of the patient; and
means for applying high frequency electromagnetic field energy to said patient where said magnetic field is applied to said patient, except to said treatment zone, to heat up said magnetic material to demagnetize it so the microspheres are not restrained by said magnetic field except in said treatment zone.

12. A system as defined in claim 11 wherein radiation emitting material is included in said microspheres .

13. A system as defined in claim 12 including means sensitive to said radiation for determining the location of said microspheres .

14. A system as defined in claim 11 wherein means for emitting gamma rays and means for emitting beta rays are included in said microspheres .
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15. A system as defined in claim 11 wherein the means for applying a high frequency field includes means for directing high frequency electromagnetic field energy having the same frequency from two different radiating " sources, and means for adjusting the relative phase of the radiation for destructive interference or substantial cancellation at the treatment zone.

16. A system as defined in claim 11 wherein the

20 magnetic field is applied to the patient from a predetermined direction adjacent the skin of the patient and wherein said high frequency electromagnetic energy is applied to the patient from substantially the same direction, at an intensity level sufficient to heat the 25 magnetic material toward the adjacent surface of the body but at an intensity insufficient to heat the magnetic material in the treatment area beyond the Curie point temperature .

30 17. A method as defined in claim 1 wherein the applying of a high frequency electromagnetic field provides a sharper delineation of microsphere concentration at the boundaries of the treatment zone by the cancellation of magnetic field components adjacent to

35 said treatment zone in conjunction with the magnetic materials having an electrically conductive composition.