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1. US20130314705 - Method of measuring a diffusion characteristic value of a particle

Office États-Unis d'Amérique
Numéro de la demande 13862021
Date de la demande 12.04.2013
Numéro de publication 20130314705
Date de publication 28.11.2013
Numéro de délivrance 08681332
Date de délivrance 25.03.2014
Type de publication B2
CIB
G01N 21/00
GPHYSIQUE
01MÉTROLOGIE; TESTS
NRECHERCHE OU ANALYSE DES MATÉRIAUX PAR DÉTERMINATION DE LEURS PROPRIÉTÉS CHIMIQUES OU PHYSIQUES
21Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c. à d. en utilisant des rayons infrarouges, visibles ou ultraviolets
G01J 1/58
GPHYSIQUE
01MÉTROLOGIE; TESTS
JMESURE DE L'INTENSITÉ, DE LA VITESSE, DU SPECTRE, DE LA POLARISATION, DE LA PHASE OU DES CARACTÉRISTIQUES D'IMPULSIONS DE LUMIÈRE INFRAROUGE, VISIBLE OU ULTRAVIOLETTE; COLORIMÉTRIE; PYROMÉTRIE DES RADIATIONS
1Photométrie, p.ex. posemètres photographiques
58en utilisant une luminescence produite par la lumière
CPC
G01N 15/0205
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
02Investigating particle size or size distribution
0205by optical means, e.g. by light scattering, diffraction, holography or imaging
G01N 15/1436
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1434using an analyser being characterised by its optical arrangement
1436the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
G01N 21/6458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
6458Fluorescence microscopy
G02B 21/0052
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
0052Optical details of the image generation
G02B 21/0076
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
0052Optical details of the image generation
0076arrangements using fluorescence or luminescence
G02B 21/008
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
008Details of detection or image processing, including general computer control
Déposants Olympus Corporation
Inventeurs Tanabe Tetsuya
Yamaguchi Mitsushiro
Mandataires Westerman, Hattori, Daniels & Adrian, LLP
Données relatives à la priorité 2010-231023 13.10.2010 JP
Titre
(EN) Method of measuring a diffusion characteristic value of a particle
Abrégé
(EN)

There is provided a method of measuring a diffusion characteristic value (for example, a diffusion constant) of a light-emitting particle using the scanning molecule counting method using the optical measurement with a confocal microscope or a multiphoton microscope. The inventive method of measuring a diffusion characteristic value of a light-emitting particle is characterized to measure light intensity from the light detection region with moving the position of the light detection region in the sample solution by changing an optical path of the optical system to generate light intensity data and to compute a diffusion characteristic value of the light-emitting particle based on a deviation time from a moving cycle time of the light detection region in an interval of generation times of two or more signals corresponding to a same light-emitting particle on the light intensity data.

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