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The present technology is directed generally to rotary displacement systems and associated methods of use and manufacture. The systems can be used to compress and/or expand compressible fluids. In some embodiments, the rotary displacement systems include a chamber housing having a pressure-modifying chamber with a first port and a second port, a first passageway in fluid communication with the chamber via the first port, and a second passageway in fluid communication with the chamber via the second port. The systems can further include a shaft positioned within the chamber housing and rotatable relative to the chamber housing about a rotational axis, and a rotor comprising no more than two lobes. The rotor can be carried by and rotatable relative to the shaft, and can be alternately operable in a first mode in which flow is provided from the first passageway to the second passageway via the chamber and in a second mode in which flow is provided from the second passageway to the first passageway via the chamber.