We claim:
1. An intermediate of formula (IX-a):
the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein:
X is CH
2 or a direct bond;
R
2 is hydrogen, C
1-6 alkyl, C
3-6 alkenyl or C
3-6 alkynyl;
R
3 is hydrogen or C
1-6 alkyl;
or
R
2 and R
3 may be taken together to form a bivalent radical of the formula --(CH
2)
m --wherein m is 4 or 5;
R
4 is hydrogen or C
1-6 alkyl;
Alk
1 is a bivalent C
1-3 alkanediyl radical;
A is a bivalent radical of the formula:
--N(R
5)--Alk
2 --N(R
6)--
wherein: each R
5 is hydrogen or C
1-4 alkyl;
each R
6 is hydrogen or C
1-4 alkyl;
Alk
2 is C
2-15 alkanediyl or C
5-7 cycloalkanediyl; and each p is 0, 1 or 2; and
R
7 and R
8 each independently are hydrogen, halo, C
1-6 alkyl, C
3-6 alkenyl, C
3-6 alkynyl, hydroxy, C
1-6 alkyloxy, cyano, aminoC
1-6 alkyl, carboxyl, C
1-6 alkyloxycarbonyl, nitro, amino, aminocarbonyl, mono-or di(C
1-6 alkyl)amino, or C
1-6 alkylcarbonylamino,
wherein in the bivalent radical (c), the free bond from the --N(R
5)--moiety is bonded to the Alk
1 moiety.
2. An intermediate according to claim 1 wherein Alk
1 is CH
2.
3. An intermediate according to claim 1 wherein X is CH
2 and wherein R
7 and R
8 each independently hydrogen, halo, C
1-6 alkyloxy, hydroxy, cyano, nitro, aminoC
1-6 alkyl, amino or C
1-6 alkylcarbonylamino.
4. An intermediate according to claim 2 wherein A is the bivalent radical of formula (a) wherein R
6 is hydrogen.
5. An intermediate according to claim 3 wherein A is the bivalent radical of formula (a) wherein R
6 is hydrogen.