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1. US20200397924 - PREPARATION METHOD OF INTERMEDIATE OF GADOLINIUM-BASED IONIC CONTRAST AGENT AND USE THEREOF

Office
États-Unis d'Amérique
Numéro de la demande 16761188
Date de la demande 19.01.2019
Numéro de publication 20200397924
Date de publication 24.12.2020
Type de publication A1
CIB
A61K 49/10
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
49Préparations pour examen in vivo
06Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM)
08caractérisées par le support
10Composés organiques
CPC
A61K 49/108
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
101the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
106the complex-forming compound being cyclic, e.g. DOTA
108the metal complex being Gd-DOTA
Déposants HUBEI TIANSHU PHARMACEUTICAL CO., LTD
Inventeurs Zhihua Zhang
Yunlong Liu
Données relatives à la priorité 201910078991.8 28.01.2019 CN
Titre
(EN) PREPARATION METHOD OF INTERMEDIATE OF GADOLINIUM-BASED IONIC CONTRAST AGENT AND USE THEREOF
Abrégé
(EN)

A preparation method and application of an intermediate of gadolinium-based ionic contrast agent comprises the following step: allowing a substance represented by the general formula (II) to react a substance represented by the general formula (III) or a substance represented by the general formula (IV) in the presence of a basic catalyst to generate an intermediate of gadolinium-based ionic contrast agent containing the structure represented by the general formula (I) or the general formula (V), wherein R represents C1-C5 alkyl, benzyl or benzyl derivative, R1 represents —H or —CH2OH, and R2 represents —CH3 or —OH. When preparing an intermediate of gadolinium-based ionic contrast agent having the structure represented by the general formula (I) using the above-mentioned preparation method, it can provide the advantages of simple reaction, fewer steps, controllable reaction, a yield up to 99% or more, and a purity greater than 99.5% for the obtained product.

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