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Paramétrages

Paramétrages

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1. US20140166108 - Microfluidic Platform

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

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Claims

1. Microfluidic platform ( 1, 2, 3, 4) having at least one means ( 12, 22, 32, 42) for initiating a movement of a liquid (P), in particular a sample liquid, between at least two locations ( 100, 101; 204, 201; 300, 301; 400, 401) of the microfluidic platform ( 1, 2, 3, 4), characterised in that the at least one means ( 12, 22, 32, 42) encompasses at least one element of changeable volume and/or shape ( 12, 22, 32, 42), which is mounted on at least one component ( 11, 21, 31, 41) movably connected to the microfluidic platform ( 1, 2, 3, 4) and by movement of the component ( 11, 21, 31, 41) can be brought into a position such that the element ( 12, 22, 32, 42), by changing its volume and/or shape, causes the liquid (P) situated at the at least one location ( 100, 204, 300, 400) to be moved at least partly from this location ( 100, 204, 300, 400) to the at least one other location ( 101, 201, 301, 401).
2. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that the at least one element of changeable volume and/or shape ( 12, 22, 32, 42) by movement of the component ( 11, 21, 31, 41) can be brought into a position such that the element ( 12, 22, 32, 42), by an increase in volume ( 12′), at least partly fills at least one cavity ( 100, 400) or by a reduction in volume ( 22′) at least partly opens up at least one cavity ( 200) that has previously been at least partly filled by the element ( 22) or, by a change in the shape of the element ( 32′), the volume (V) of at least one cavity ( 300 and 313) at least partly delimited by the element ( 32) can be changed (V′).
3. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that the component ( 11, 21, 31, 41) is of a cover-like configuration and in at least one position covers at least one cavity ( 100, 200, 300, 400).
4. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that the cover-like component ( 11, 21, 31, 41) covers the microfluidic platform ( 1, 2, 3, 4) at least from two opposite sides.
5. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that the cover-like component ( 11, 21, 31, 41) is slidably or pivotably connected to the microfluidic platform ( 1, 2, 3, 4).
6. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that at least one sealing device ( 13, 23, 33, 43) is provided, such that in the at least one position of the cover-like component ( 11, 21, 31, 41) covering the at least one cavity ( 100, 200, 300, 400) the covered cavity ( 100, 200, 300, 400) is outwardly sealed.
7. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that the sealing device ( 13, 23, 33, 43) is provided on the cover-like component ( 11, 21, 31, 41) on the side facing the at least one cavity ( 100, 200, 300, 400) that is to be covered.
8. Microfluidic platform ( 1, 2, 3, 4) according to claim 1, characterised in that the cover-like component ( 11, 21, 31, 41) comprises at least one cavity ( 113, 213) or opening ( 313), in which the at least one element of changeable volume and/or shape ( 12, 22, 32, 42) is at least partly held.
9. Microfluidic platform ( 1, 4) according to claim 2, characterised in that the element of changeable volume and/or shape ( 12, 42) is compressed in a first position of the cover-like component ( 11, 41) that exposes the cavity ( 100, 400) and the cover-like component ( 11, 41) can be brought into a second position in which the cavity ( 100, 400) is sealingly covered and the element of changeable volume and/or shape ( 12, 42) has relaxed into the cavity ( 100, 400), the cavity ( 100, 400) being fluidically connected to at least one other cavity ( 101, 401), particularly a sample utilisation area.
10. Microfluidic platform ( 1, 4) according to claim 9, characterised in that the cavity ( 100, 400) is a sample application area of a technical medical measuring instrument, for example, a microfluidic cartridge, a test strip or the like.
11. Microfluidic platform ( 2) according to claim 2, characterised in that the element of changeable volume and/or shape ( 22), in a first position of the cover-like component ( 21), has relaxed into a cavity ( 200) of the microfluidic platform ( 2) and the cover-like component ( 21) can be brought into a second position that sealingly covers the cavity ( 200), in which the element of changeable volume and/or shape ( 22) has freed up the cavity ( 200) again and has been compressed, the cavity ( 200) of the microfluidic platform ( 2) being fluidically connected to at least one other cavity ( 201, 204), particularly a sample utilisation area ( 201) and/or a sample application area ( 204).
12. Microfluidic platform ( 2) according to claim 11, characterised in that the element of changeable volume or shape ( 22) comprises bevels ( 220) on the side facing the cavity ( 200).
13. Microfluidic platform ( 3) according to claim 2, characterised in that the element of changeable volume and/or shape ( 32) is of membrane-like configuration and the cover-like component ( 31) can be brought into a position in which at least one cavity ( 300+ 313) is sealingly covered and wherein the membrane-like element ( 32) at least partly delimits the at least one cavity ( 300+ 313), while pressure on the membrane-like element ( 32) causes a reduction (V′) in the volume (V) of the at least one cavity ( 300+ 313) limited thereby ( 32) at least in parts.
14. Microfluidic platform ( 4) according to claim 2, characterised in that it ( 4) comprises a plurality of cavities ( 400) and a plurality of elements of changeable volume and/or shape ( 42) are provided, which are mounted on the at least one component ( 41) that is movably connected to the microfluidic platform ( 4).
15. Method of initiating a movement of a liquid (P), particularly a sample liquid, between at least two locations ( 100, 101; 204, 201;
300, 301; 400, 401) of a microfluidic platform ( 1, 2, 3, 4), having t least one means ( 12, 22, 32, 42) for initiating a movement of a liquid (P), in Particular a sample liquid, between at least two locations ( 100, 101; 204, 201; 300, 301; 400, 401) of the microfluidic platform ( 1, 2, 3, 4), characterised in that the at least one means ( 12, 22, 32, 42) encompasses at least one element of changeable volume and/or shape ( 12, 22, 32, 42), which is mounted on at least one component ( 11, 21, 31, 41) movably connected to the microfluidic platform ( 1, 2, 3, 4) and by movement of the component ( 11, 21, 31, 41) can be brought into a position such that the element ( 12, 22, 32, 42), by changing its volume and/or shape, causes the liquid (P) situated at the at least one location ( 100, 204, 300, 400) to be moved at least partly from this location ( 100, 204, 300, 400) to the at least one other location ( 101, 201, 301, 401), said method being characterised by at least the following process steps:
at least one cavity ( 100, 200, 300, 400) is sealingly covered (S 1, S 1′, Si″) by at least one component ( 11, 21, 31, 41) which is movably connected to the microfluidic platform ( 1, 2, 3, 4)
least one element of changeable volume and/or shape ( 12, 22, 32, 42) mounted on the at least one component ( 11, 21, 31, 41) movably connected to the microfluidic platform ( 1, 2, 3, 4), is changed in its volume and/or in its shape (S 2, S 2′, S 2″such that a liquid (P) located in the at least one cavity ( 100, 200, 300, 400) is at least partly moved out of the cavity ( 100, 300, 400) or such that a liquid (P) is moved at least in the direction of this cavity ( 200).
16. Method according to claim 15, characterised in that the at least one element of changeable volume and/or shape ( 12, 22, 32, 42) is brought, by movement of the component ( 11, 21, 31, 41), into a position such that the element ( 12, 42), by increasing in volume, at least partly fills the at least one cavity ( 100, 400) or by decreasing in volume, at least partly frees up the at least one cavity that has previously been at least partly filled by the element ( 22) or, by a change in the shape of the element ( 32), the volume (V) of at least one cavity ( 300, 313) that is at least partly delimited by the element ( 32) is altered (V′).
17. Method according to claim 15, characterised in that the element of changeable volume and/or shape ( 12, 42) is compressed in a first position of the cover-like component ( 11, 41) that frees up the cavity ( 100, 400) and the cover-like component ( 11, 41) is brought into a second position, in which the cavity ( 100, 400) is sealingly covered and the element of changeable volume and/or shape ( 12, 42) relaxes into the cavity ( 100, 400), the cavity ( 100, 400) being fluidically connected to at least one other cavity ( 101), particularly a sample utilisation area.
18. Method according to claim 15, characterised in that the element of changeable volume and/or shape ( 22) in a first position of the cover-like component ( 21) is relaxed into a cavity ( 200) of the microfluidic platform ( 2) and the cover-like component ( 21) is brought into a second position that sealingly covers the cavity ( 200), in which the element of changeable volume and/or shape ( 22) has freed up the cavity ( 200) again and has been compressed, the cavity ( 200) of the microfluidic platform ( 2) being fluidically connected to at least one other cavity ( 201, 204), particularly to a sample utilisation area ( 201) and a sample application area ( 204).
19. Method according to claim 15, characterised in that the element of changeable volume and/or shape ( 32) is of membrane-like configuration and the cover-like component ( 31) is brought into a position in which at least one cavity ( 300+ 313) is sealingly covered and wherein the membrane-like element ( 32) at least partly delimits the at least one cavity ( 300+ 313), while as a result of pressure on the membrane-like element ( 32) the volume (V) of the at least one cavity ( 300+ 313) at least partly delimited thereby is reduced (V′).