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1. SG11201909761W - SECONDARY AMINE-SUBSTITUTED COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LABELS

Office
Singapour
Numéro de la demande 11201909761W
Date de la demande 16.10.2018
Numéro de publication 11201909761W
Date de publication 27.02.2020
Type de publication A1
CIB
C07D 405/04
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
405Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle
02contenant deux hétérocycles
04liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 413/04
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
413Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle
02contenant deux hétérocycles
04liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 417/04
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
417Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe C07D415/211
02contenant deux hétérocycles
04liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07F 9/44
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
FCOMPOSÉS ACYCLIQUES, CARBOCYCLIQUES OU HÉTÉROCYCLIQUES CONTENANT DES ÉLÉMENTS AUTRES QUE LE CARBONE, L'HYDROGÈNE, LES HALOGÈNES, L'OXYGÈNE, L'AZOTE, LE SOUFRE, LE SÉLÉNIUM OU LE TELLURE
9Composés contenant des éléments des groupes 5 ou 15 de la classification périodique
02Composés du phosphore
28à une ou plusieurs liaisons P-C
38Acides phosphoniques ; Acides thiophosphoniques
44Leurs amides
C12Q 1/68
CCHIMIE; MÉTALLURGIE
12BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
QPROCÉDÉS DE MESURE OU DE TEST FAISANT INTERVENIR DES ENZYMES, DES ACIDES NUCLÉIQUES OU DES MICRO-ORGANISMES; COMPOSITIONS OU PAPIERS RÉACTIFS À CET EFFET; PROCÉDÉS POUR PRÉPARER CES COMPOSITIONS; PROCÉDÉS DE COMMANDE SENSIBLES AUX CONDITIONS DU MILIEU DANS LES PROCÉDÉS MICROBIOLOGIQUES OU ENZYMOLOGIQUES
1Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
68faisant intervenir des acides nucléiques
CPC
C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 413/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 417/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07F 9/65586
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
65586at least one of the hetero rings does not contain nitrogen as ring hetero atom
C07F 9/65616
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
65616containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
Déposants ILLUMINA CAMBRIDGE LIMITED
Inventeurs ROMANOV, Nikolai Nikolaevich
MCCAULEY, Patrick
ANASTASI, Carole
WU, Xiaolin
HYNES, Niall
Données relatives à la priorité 1716931.9 16.10.2017 GB
Titre
(EN) SECONDARY AMINE-SUBSTITUTED COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LABELS
Abrégé
(EN)
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 April 2019 (25.04.2019) WIPO I PCT 1111111111111101111111111111111011111010111111111111111111111111111101111111011110111111 (10) International Publication Number WO 2019/077331 Al (51) International Patent Classification: C07D 405/04 (2006.01) CO7F 9/44 (2006.01) C07D 413/04 (2006.01) Cl 2Q 1/68 (2018.01) C07D 417/04 (2006.01) (21) International Application Number: PCT/GB2018/052971 (22) International Filing Date: 16 October 2018 (16.10.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1716931.9 16 October 2017 (16.10.2017) GB (71) Applicant: ILLUMINA CAMBRIDGE LIMITED [GB/GB]; Chesterford Research Park, Little Chesterford, Nr Saffron Walden Essex CB10 1XL (GB). (72) Inventors: ROMANOV, Nikolai Nikolaevich; c/o Illumi- na Cambridge Limited, Chesterford Research Park, Little Chesterford, Nr Saffron Walden Essex CB10 1XL (GB). MCCAULEY, Patrick; c/o Illumina Cambridge Limit- ed, Chesterford Research Park, Little Chesterford, Nr Saf- fron Walden Essex CB10 1XL (GB). ANASTASI, Car- ole; c/o Illumina Cambridge Limited, Chesterford Research Park, Little Chesterford, Nr Saffron Walden Essex CB10 1XL (GB). WU, Xiaolin; c/o Illumina Cambridge Limited, Chesterford Research Park, Little Chesterford, Nr Saffron Walden Essex CB10 1XL (GB). HYNES, Niall; c/o Illu- mina Cambridge Limited, Chesterford Research Park, Little Chesterford, Nr Saffron Walden Essex CB10 1XL (GB). (74) Agent: MURGITROYD & COMPANY; Scotland House, 165-169 Scotland Street, Glasgow Strathclyde G5 8PL (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, 1E, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) • (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, 1-1 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM AZ, BY, KG, KZ, RU, TJ, N O ON ▪ (54) Title: SECONDARY AMINE-SUBSTITUTED COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LA- BELS \" (57) Abstract: The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. C The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.