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1. (SG11201610036P) ANTIBODIES DIRECTED AGAINST CD127

Office : Singapour
Numéro de la demande : 11201610036P Date de la demande : 10.06.2015
Numéro de publication : 11201610036P Date de publication : 29.12.2016
Type de publication : A1
Référence PCT: Numéro de la demande :PCTEP2015062993 ; Numéro de publication :2015189302 Cliquer pour voir les données
CIB :
C07K 16/28
A61K 39/00
C CHIMIE; MÉTALLURGIE
07
CHIMIE ORGANIQUE
K
PEPTIDES
16
Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
18
contre du matériel provenant d'animaux ou d'humains
28
contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A NÉCESSITÉS COURANTES DE LA VIE
61
SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K
PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39
Préparations médicinales contenant des antigènes ou des anticorps
Déposants : OSE IMMUNOTHERAPEUTICS
Inventeurs : Nicolas Poirier
Caroline Mary
Bernard Vanhove
Données relatives à la priorité : 15305078.6 23.01.2015 EP
62/010,117 10.06.2014 US
Titre : (EN) ANTIBODIES DIRECTED AGAINST CD127
Abrégé :
(EN) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 December 2015 (17.12.2015) WIPOIPCT (10) International Publication Number WO 2015/189302 A1 (51) International Patent Classification: C07K16/28 (2006.01) A61K39/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2015/062993 10 June 2015 (10.06.2015) English English (30) Priority Data: 62/010,117 15305078.6 10 June 2014 (10.06.2014) US 23 January 2015 (23.01.2015) EP (71) Applicant: EFFIMUNE [FR/FR]; 1, rue Gaston Veil, F- 44035 Nantes (FR). (72) Inventors: POIRIER, Nicolas; 1, chemin du Passe- Temps, F-44119 Treillieres (FR). MARY, Caroline; 7, rue du Buisson, F-44680 Sainte-Pazanne (FR). VANHOVE, Bernard; 72, bis Rue Henri Barbusse, F-44400 Reze (FR). (74) Agents: GUTMANN, Ernest et al.; 3, rue Auber, F-75009 Paris (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) CJ o m o\ 00 i-H i?) T-H o CJ o & (54) Title: ANTIBODIES DIRECTED AGAINST CD 127 (57) Abstract: The invention relates to antibodies directed against CD 127, the alpha chain of the interleukin 7 (IL-7) receptor IL- 7R), and which have antagonist properties for IL-7-IL-7R interaction, may present cytotoxic activity against CD127 positive cells but do not increase the maturation of dendritic cells (DCs) induced by TSLP, a cytokine also using CD127 as part of its receptor. Al­ ternatively, or in addition, these antibodies do not induce the internalization of CD127 and/or inhibit the IL7-induced internalization of CD127. According to another aspect of the invention antibodies are provided which recognize a human CD127 epitope compris - ing sequences from the 2b site of CD 127, in particular the epitope comprising comprises the human CD 127 sequences of domain D1 and of the 2b site of CD127, in particular the epitope comprises at least one sequence from D1 comprising SEQ ID No: 115 (in par­ ticular comprising SEQ ID No: 10) and/or SEQ ID No: 111 and / or a sequence from the 2b site comprising the sequence of SEQ ID No: 116 and optionally also comprises SEQ ID No: 117 (in particular comprises SEQ ID No: 11 l).The antibodies of the invention are suitable for use inorder to remedy to a condition diagnosed in a human patient which results from pathogenesis related to lymph­ opoiesis, when IL-7 signalling pathways provide contribution to said pathogenesis, especially when an increase in the maturation, more precisely the upregulation of costimulatory molecules, of dendritic cells is undesirable.
Également publié sous:
UAa201613258CA2950823AU2015273532EP3155014KR1020170019417US20170129959
IL249449CN106715471VN52585MYPI 2016002094PH1/2016/502445JP2017522903
TH171839IN201617042413BR112016028755TN2016000528EA201692460RU2016151265
CR20160576WO/2015/189302