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1. KR1020210074237 - 가돌리늄계 이온성 조영제 중간체의 제조방법 및 그 용도

Office
République de Corée
Numéro de la demande 1020207012696
Date de la demande 29.01.2019
Numéro de publication 1020210074237
Date de publication 21.06.2021
Type de publication A
CIB
C07D 405/04
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
405Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle
02contenant deux hétérocycles
04liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 49/10
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
49Préparations pour examen in vivo
06Préparations de contraste pour la résonance magnétique nucléaire (RMN); Préparations de contraste pour l'imagerie par résonance magnétique (IRM)
08caractérisées par le support
10Composés organiques
C07D 257/02
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
257Composés hétérocycliques contenant des cycles comportant quatre atomes d'azote comme uniques hétéro-atomes du cycle
02non condensés avec d'autres cycles
CPC
C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
A61K 49/106
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
101the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
106the complex-forming compound being cyclic, e.g. DOTA
A61K 49/108
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
101the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
106the complex-forming compound being cyclic, e.g. DOTA
108the metal complex being Gd-DOTA
C07D 257/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
Déposants 후베이 티안슈 파마슈티칼 컴퍼니 리미티드
Inventeurs 장, 즈화
리우, 윈롱
Mandataires 이철희
Données relatives à la priorité 201910078991.8 28.01.2019 CN
Titre
(KO) 가돌리늄계 이온성 조영제 중간체의 제조방법 및 그 용도
Abrégé
(KO)
본 발명은 가돌리늄계 이온성 조영제 중간체의 제조방법 및 그 용도를 제공한다. 상기 제조방법은 일반식 (II)로 표시되는 물질과 일반식 (III)로 표시되는 물질 또는 일반식 (IV)로 표시되는 물질을 염기성 촉매의 존재 하에 반응시켜 일반식 (I) 또는 일반식 (V)로 표시되는 구조를 포함하는 가돌리늄계 이온성 조영제 중간체를 생성하는 단계를 포함하며; 여기서, R은 C-C의 알킬, 벤질 또는 벤질 유도체를 나타내고, R은 -H 또는 -CHOH를 나타내며, R는 -CH 또는 -OH를 나타낸다. 상기 제조방법을 사용하여 일반식 (I)로 표시되는 구조를 포함하는 가돌리늄계 이온성 조영제 중간체를 제조하는 경우, 반응이 간단하고, 단계가 적으며, 반응에 대한 제어가 가능하며, 수율은 99% 이상에 도달할 수 있으며, 수득된 생성물의 순도는 99.5%보다 높다. 1 5 1 2 2 3

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