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1. KR1020200090233 - 암 및 관련된 악성 종양의 치료를 위해 γδ T 세포를 활성화시키고 변형시키고 확장시키는 방법

Office République de Corée
Numéro de la demande 1020207018404
Date de la demande 26.11.2018
Numéro de publication 1020200090233
Date de publication 28.07.2020
Type de publication A
CIB
C12N 5/0783
CCHIMIE; MÉTALLURGIE
12BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
NMICRO-ORGANISMES OU ENZYMES; COMPOSITIONS LES CONTENANT; CULTURE OU CONSERVATION DE MICRO-ORGANISMES; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE; MILIEUX DE CULTURE
5Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
07Cellules animales ou tissus animaux
071Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
078Cellules du sang ou du système immunitaire
0783Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
A61K 31/663
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
66Composés du phosphore
662Acides du phosphore ou leurs esters ayant des liaisons P-C, p.ex. foscarnet, trichlorfon
663Composés ayant plusieurs groupes acide du phosphore ou leurs esters, p.ex. acide clodronique, acide pamidronique
A61K 31/675
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
66Composés du phosphore
675ayant l'azote comme hétéro-atome d'un cycle, p.ex. phosphate de pyridoxal
A61K 38/20
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
38Préparations médicinales contenant des peptides
16Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
17provenant d'animaux; provenant d'humains
19Cytokines; Lymphokines; Interférons
20Interleukines
C07K 14/54
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
14Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
435provenant d'animaux; provenant d'humains
52Cytokines; Lymphokines; Interférons
54Interleukines (IL)
C07K 14/55
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
14Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
435provenant d'animaux; provenant d'humains
52Cytokines; Lymphokines; Interférons
54Interleukines (IL)
55IL-2
CPC
C12N 5/0638
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0634Cells from the blood or the immune system
0636T lymphocytes
0638Cytotoxic T lymphocytes [CTL], lymphokine activated killer cells [LAK]
A61K 31/663
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 38/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
2013IL-2
C07K 14/5443
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
5443IL-15
C07K 14/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
55IL-2
Déposants 이매틱스 유에스 인코포레이티드
Inventeurs 다오 모니크
마타 멜린다
노윅카 알렉산드라
불리어드 얀닉
월터 스테판
미셀 사라
쿠트루프-코퀴 사브리나
힐프 노르베르트
Mandataires 제일특허법인(유)
Données relatives à la priorité 10 2017 127 984.9 27.11.2017 DE
62/591,041 27.11.2017 US
Titre
(KO) 암 및 관련된 악성 종양의 치료를 위해 γδ T 세포를 활성화시키고 변형시키고 확장시키는 방법
Abrégé
(KO)
본 발명은 T 세포의 확장 및 활성화에 관한 것이다. 한 양태에서, 본 발명은 형질도입 유전자 발현에 사용될 수 있는 γδ T 세포의 확장 및 활성화에 관한 것이다. 다른 양태에서, 본 발명은 α- 및/또는 β-TCR 양성 세포를 고갈시키는 동안 γδ T 세포의 확장 및 활성화에 관한 것이다. 확장된 γδ T 세포 및 고갈되거나 감소된 α- 및/또는 β-TCR 양성 세포로 구성된 T 세포군 또한 본 발명의 개시에서 제공된다. 본 발명은 개시된 T 세포군을 사용하는 방법 또한 제공한다.

Également publié en tant que
EP2018830327
JP2020546300
MXMX/a/2020/005503