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1. KR102027311 - METHOD TO PRODUCE NANO DIAGNOSTIC AGENT CAPABLE OF SELECTIVE STAINING OF INFLAMMATORY ABNORMAL TISSUES OR TUMOR TISSUES

Office République de Corée
Numéro de la demande 1020190035390
Date de la demande 27.03.2019
Numéro de publication 102027311
Date de publication 02.10.2019
Numéro de délivrance 102027311
Date de délivrance 02.10.2019
Type de publication B1
CIB
A61K 49/00
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
49Préparations pour examen in vivo
CPC
A61K 49/0082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0063characterised by a special physical or galenical form, e.g. emulsions, microspheres
0069the agent being in a particular physical galenical form
0076dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
0082micelle, e.g. phospholipidic micelle and polymeric micelle
A61K 49/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
006Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
Déposants 주식회사 티젤바이오
Inventeurs OH KEUN SANG
CHO HAN WEON
HWANG, CHANG SOON
KIM, SUN JONG
CHUNG HYE SOOK
오근상
LEE HYE JIN
조한원
황창순
김선종
정혜숙
이혜진
Mandataires 박기하
김지헌
서무원
Titre
(EN) METHOD TO PRODUCE NANO DIAGNOSTIC AGENT CAPABLE OF SELECTIVE STAINING OF INFLAMMATORY ABNORMAL TISSUES OR TUMOR TISSUES
(KO) 염증성 비정상 조직 또는 종양 조직의 선택적 염색이 가능한 나노 진단 제제의 제조 방법
Abrégé
(EN)
The present invention relates to a method for producing a nano diagnostic agent capable of a selective staining of inflammatory abnormal tissues or tumor tissues. According to the present invention, the nano diagnostic agent producing method includes: a step of forming a first mixture by mixing polysorbate 80, soybean oil and a water insoluble staining material; a step of forming a second mixture by mixing the first mixture with a triblock copolymer and heating the mixture; a step of forming a nano platform solid by cooling the second mixture; a step of forming a third mixture by mixing a solvent with the nano platform solid; a step of removing foreign matter from the third mixture; and a step of forming a nano composite by freezing and drying the third mixture from which the foreign matter is removed. By the above, the present invention is able to increase search efficiency of a disease part by being transmitted through micropores of tumor by direct permeation and absorption, and precisely distinguishing normal tissues from abnormal tissues. COPYRIGHT KIPO 2020

(KO)
본 발명은 염증성 비정상 조직 또는 종양 조직의 선택적 염색이 가능한 나노 진단 제제의 제조 방법에 관한 것이다. 본 발명에 따른 나노 진단 제제의 제조 방법은 폴리소르베이트 80(polysorbate 80), 대두 오일(soybean oil) 및 비수용성 염색 물질을 혼합하여, 제 1 혼합물을 형성하는 단계; 제 1 혼합물과 삼중 블록 공중합체를 혼합한 후 가열하여, 제 2 혼합물을 형성하는 단계; 상기 제 2 혼합물을 냉각하여, 나노 플랫폼 고형물을 형성하는 단계; 상기 나노 플랫폼 고형물에 용매를 혼합하여, 제 3 혼합물을 형성하는 단계; 상기 제 3 혼합물로부터 불순물을 제거하는 단계; 및 상기 불순물이 제거된 제 3 혼합물을 동결건조하여, 나노 복합체를 형성하는 단계를 포함하는 것을 특징으로 한다. 이에 의하여, 종양의 미세 기공을 통해 직접 투과 및 흡수를 통해 전달되어 정상 조직과 비정상 조직을 정밀하게 구분하여, 질환 부위의 탐색 효율성을 높일 수 있다.

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