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1. JP2015110786 - REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS IN FLOW-THROUGH MODE

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Japon
Numéro de la demande 2015000657
Date de la demande 06.01.2015
Numéro de publication 2015110786
Date de publication 18.06.2015
Numéro de délivrance 6231027
Date de délivrance 27.10.2017
Type de publication B2
CIB
C08F 265/10
CCHIMIE; MÉTALLURGIE
08COMPOSÉS MACROMOLÉCULAIRES ORGANIQUES; LEUR PRÉPARATION OU LEUR MISE EN UVRE CHIMIQUE; COMPOSITIONS À BASE DE COMPOSÉS MACROMOLÉCULAIRES
FCOMPOSÉS MACROMOLÉCULAIRES OBTENUS PAR DES RÉACTIONS FAISANT INTERVENIR UNIQUEMENT DES LIAISONS NON SATURÉES CARBONE-CARBONE
265Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères d'acides monocarboxyliques non saturés ou de leurs dérivés tels que définis dans le groupe C08F20/204
10sur des polymères d'amides ou d'imides
C07K 1/16
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
1Procédés généraux de préparation de peptides
14Extraction; Séparation; Purification
16par chromatographie
CPC
B01D 15/362
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction
361Ion-exchange
362Cation-exchange
C07K 1/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
16by chromatography
165mixed-mode chromatography
C07K 1/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
16by chromatography
18Ion-exchange chromatography
B01D 15/363
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction
361Ion-exchange
363Anion-exchange
B01D 15/3809
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
38involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
3804Affinity chromatography
3809of the antigen-antibody type, e.g. protein A, G, L chromatography
B01J 39/20
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
39Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
08Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
16Organic material
18Macromolecular compounds
20obtained by reactions only involving unsaturated carbon-to-carbon bonds
Déposants MERCK PATENT GMBH
メルク　パテント　ゲーエムベーハー
Inventeurs MIKHAIL KOZLOV
ミハイル・コズロフ
CATALDO WILLIAM
ウイリアム・カタルド
POTTY AJISH
アジシユ・ポテイ
GALIPEAU KEVIN
ケビン・ガリポー
JAMES HAMZIK
ジエームズ・ハムジク
UMANA JOAQUIN
ホアキン・ウマーナ
LARS PEECK
ラルス・ピーク
Mandataires 特許業務法人川口國際特許事務所
Données relatives à la priorité 61/609,533 12.03.2012 US
61/666,578 29.06.2012 US
Titre
(EN) REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS IN FLOW-THROUGH MODE
(JA) フロースルー式での生物製剤からのタンパク質凝集体の除去
Abrégé
(EN)

PROBLEM TO BE SOLVED: To provide novel polymers for removal of protein aggregates from a sample in a flow-through mode.

SOLUTION: A polymer comprises the following chemical structure wherein R1 is a cation-exchange group; R2 is any aliphatic or aromatic organic residue that does not contain a charged group; R3 is any uncharged aliphatic or aromatic organic linker between any two or more polymeric chains; x, y, and z are average molar fractions of each monomer in the polymer, wherein y>x; and m denotes a similar polymer chain attached at the other end of the linker.

COPYRIGHT: (C)2015,JPO&INPIT


(JA)

【課題】フロースルー式で試料からタンパク質凝集体を除去する新規のポリマーの提供。
【解決手段】以下で表される化学構造を含むポリマー。

［Ｒ１は陽イオン交換基；Ｒ２は荷電基を含まない任意の脂肪族又は芳香族有機残基；Ｒ３は任意の２つ以上のポリマー鎖間の任意の非荷電脂肪族又は芳香族有機リンカー；ｘ、ｙおよびｚはポリマー中の各モノマーの平均モル分率；ｙ＞ｘ；ｍはリンカーの他端に結合している類似のポリマー鎖］
【選択図】なし
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