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1. IN10000/DELNP/2014 - MULTIMERIC COMPLEXES WITH IMPROVED IN VIVO STABILITY PHARMACOKINETICS AND EFFICACY

Office
Inde
Numéro de la demande 10000/DELNP/2014
Date de la demande 25.11.2014
Numéro de publication 10000/DELNP/2014
Date de publication 31.08.2016
Type de publication A
CIB
A61K 39/00
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39Préparations médicinales contenant des antigènes ou des anticorps
Déposants IBC PHARMACEUTICALS INC.
Inventeurs ROSSI Edmund A.
CHANG Chien Hsing
GOLDENBERG David M.
Données relatives à la priorité 61/654310 01.06.2012 US
61/662086 20.06.2012 US
61/673553 19.07.2012 US
61/682531 13.08.2012 US
61/693042 24.08.2012 US
61/694072 28.08.2012 US
Titre
(EN) MULTIMERIC COMPLEXES WITH IMPROVED IN VIVO STABILITY PHARMACOKINETICS AND EFFICACY
Abrégé
(EN) in vivoThe present invention concerns multimeric complexes based on antibody fusion proteins comprising an AD moiety attached to the C terminal end of each antibody light chain. The complexes further comprise effector moities attached to DDD moieties. Two copies of the DDD moiety form a dimer that binds to the AD moiety. The complexes may be trimers pentamers hexamers or other multimers. The effector moieties may be selected from a second antibody or antigen binding fragment thereof a cytokine an interferon a toxin an antigen a xenoantigen a hapten a protamine a hormone an enzyme a ligand binding protein a pro apoptotic agent and an anti angiogenic agent. Surprisingly attachment of the AD moiety to the C terminal end of the antibody light chain results in improved pharmacokinetics and stability and efficacy compared to homologous complexes wherein the AD moiety is attached to the antibody heavy chain.
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