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1. IN1955/CHENP/2013 - METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES

Office Inde
Numéro de la demande 1955/CHENP/2013
Date de la demande 12.03.2013
Numéro de publication 1955/CHENP/2013
Date de publication 26.09.2014
Type de publication A
CIB
C07K 16/00
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
16Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
C07K 16/46
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
16Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux
46Immunoglobulines hybrides
Déposants NOVIMMUNE S.A.
Inventeurs FISCHER Nicolas
MAGISTRELLI Giovanni
GUENEAU Franck
RAVN Ulla
ELSON Greg
Données relatives à la priorité 12415910 31.03.2009 US
61/443008 15.02.2011 US
61/509260 19.07.2011 US
Titre
(EN) METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES
Abrégé
(EN)
The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non human sequences as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.