A method for producing particles of predetermined sized and/or morphology of a substance ina production arrangement comprising the steps of: i) mixing within a spray nozzle and underflow conditions a stream of a liquid solution in which the substance is dissolved with a streamof a fluid, and ii) passing the mixture in the form of a spray through a spray outlet of thenozzle into a particle collecting container, and iii) separating and collecting within thecontainer the particles. The characteristic feature is that the solvent is a liquid and the fluid isan aqueous liquid in a subcritical state. Preferred nozzles have two coaxial internal transportconduits. One aspect is a production arrangement that can be used in the method. Itscharacteristic features are functions for a) recycling fluid used in the process, b) for includinga make-up agent in the fluid stream, and/or increasing production by paralleling particleformation.