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1. IN7030/CHENP/2010 - NOVEL AMINO ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF

Office Inde
Numéro de la demande 7030/CHENP/2010
Date de la demande 01.11.2010
Numéro de publication 7030/CHENP/2010
Date de publication 22.07.2011
Type de publication A
CIB
C07C 32/60
C07C 32/65
Déposants PHARMALEADS
Inventeurs FOURNIE-ZALUSKI, MARIE-CLAUDE
PORAS, HERVE
ROQUES, BERNARD
Données relatives à la priorité 0853092 13.05.2008 FR
Titre
(EN) NOVEL AMINO ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF
Abrégé
(EN)
The invention relates to novel compounds of the formula (I) R1NH-CH(R2)-CH2-S- S-CH2-C(R3)(R4)-CONH-C(R5)(R6)-COOR7, in which R1, is a (acyloxy)alkyl carbamate -C(O)-O-C(R8)(R9)-OC(O)-R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle; R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR)12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The invention also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier. The invention further relates to the combined use of at least one cannabinoid derivative and/or morphine or one derivative thereof and/or Gaba derivatives for enhancing the analgesic and anti-depressive effect of the novel compounds of the formula (I).