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1. CN102711801 - Method for treating heart failure with stresscopin-like peptides

Office
Chine
Numéro de la demande 201080060620.4
Date de la demande 04.11.2010
Numéro de publication 102711801
Date de publication 03.10.2012
Type de publication A
CPC
A61K 38/2228
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
2228Corticotropin releasing factor [CRF] (Urotensin)
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Déposants Janssen Pharmaceutica NV
Inventeurs Gengo Peter J.
Sabbah Hani N.
Shankley Nigel P.
Mandataires kong jing li jin
Données relatives à la priorité 12612548 04.11.2009 US
61/258181 04.11.2009 US
Titre
(EN) Method for treating heart failure with stresscopin-like peptides
(ZH) 用顶压素样肽治疗心力衰竭的方法
Abrégé
(EN)
The present invention relates to novel methods of treating heart failure comprising administering an amount of stresscopin-like peptide to a subject in need thereof; and substantially maintaining the amount of said peptide present in the plasma of said subject at a concentration resulting in a therapeutic benefit without a substantial increase in the heart rate of said subject. The method involves the use of stresscopin-like peptides that are selective corticotrophin releasing hormone receptor type 2 (CRHR2) agonists.

(ZH)

本发明涉及治疗心力衰竭的新方法,所述方法包括给有此需求的受试者施用某个量的顶压素样肽;并且以产生治疗有益效果而不引起所述受试者心率明显增加的浓度基本上维持存在于所述受试者血浆中的所述肽的量。所述方法包括使用作为选择性促皮质素释放激素2型受体(CRHR2)激动剂的顶压素样肽。