(EN)
Methods for the prevention or treatment of a typical depression secondary to pain (DSP) have been developed. The method generally involves administering an effective amount of a monoamine re uptake inhibitor to treat or prevent symptoms of DSP. In a preferred embodiment, a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor (SRNI) compound of a specific type, or a pharmaceutically acceptable salt thereof is administered. The most preferred SNRI compounds are non-tricyclic SNRIs, wherein serotonin reuptake inhibition is greater than norepinephrine reuptake inhibition; and NSRIs, wherein norepinephrine reuptake inhibition is greater than serotonin reuptake inhibition. The most preferred compound is milnacipran or a bioequivalent or pharmaceutically acceptable salt thereof. Other preferred compounds are duloxetine and venlafaxine or a bioequivalent or pharmaceutically acceptable salt thereof. In yet another embodiment, a therapeutically effective amount of a non-tricyclic triple reuptake inhibitor ('TRI') compound of a specific type, or a pharmaceutically acceptable salt thereof, is administered. The TRI compounds are characterized by their ability to block the reuptake (and, hence, increase central concentrations of) the three primary brain monoamines: serotonin, noradrenaline, and dopamine.
(ZH) 本发明研发出了治疗或预防非典型疼痛继发性抑郁(DSP)的方法。本方法通常包括给药有效剂量的单胺再摄取抑制剂以治疗或预防DSP症状。在优选实施方案中，给药一特定类型治疗有效剂量的双重血清素去甲肾上腺素再摄取抑制剂(SRNI)化合物或其药物可接受盐。最优选SNRI化合物是非三环的SNRIs化合物，其中对血清素再摄取抑制作用强于对去甲肾上腺素再摄取抑制作用；NSRIs，其中对去甲肾上腺素再摄取抑制作用强于对血清素再摄取抑制作用。最优选的化合物是米那普仑或其生物等效或药物可接受盐。其它优选的化合物是度洛西汀(duloxetine)，文拉法新(venlafaxine)或其生物等效或药物可接受盐。在另一实施方案中，给药了一特定类型治疗有效剂量非三环三重再摄取抑制剂(“TRI”)化合物，或其药物可接受盐。TRI化合物特征在于能阻断三种主要的大脑单胺：血清素，去甲肾上腺素和多巴胺的再摄取(并因此增加中枢浓度)。
