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1. CN1474707 - Myogenic cell transfer catheter and method

Office Chine
Numéro de la demande 01818710.2
Date de la demande 11.09.2001
Numéro de publication 1474707
Date de publication 11.02.2004
Type de publication A
CIB
A61M 31/00
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
MDISPOSITIFS POUR INTRODUIRE DES AGENTS DANS LE CORPS OU LES DÉPOSER SUR CELUI-CI; DISPOSITIFS POUR FAIRE CIRCULER DES AGENTS DANS LE CORPS OU POUR LES EN RETIRER; DISPOSITIFS POUR PROVOQUER LE SOMMEIL OU LA LÉTHARGIE OU POUR Y METTRE FIN
31Dispositifs pour l'introduction ou la rétention d'agents, p.ex. de remèdes, dans les cavités du corps
CPC
A61B 5/053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
053Measuring electrical impedance or conductance of a portion of the body
A61B 5/0538
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
053Measuring electrical impedance or conductance of a portion of the body
0538invasively, e.g. using a catheter
A61B 5/4519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
45For evaluating or diagnosing the musculoskeletal system or teeth
4519Muscles
A61B 5/4839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
4839combined with drug delivery
A61B 2017/00247
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
00234for minimally invasive surgery
00238Type of minimally invasive operation
00243cardiac
00247Making holes in the wall of the heart, e.g. laser Myocardial revascularization
A61B 2018/00392
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
00315for treatment of particular body parts
00345Vascular system
00351Heart
00392Transmyocardial revascularisation
Déposants Peter K. Law
彼得·K·罗
Inventeurs Peter K. Law
彼得·K·罗
Mandataires zhou beilin
中国专利代理(香港)有限公司
Données relatives à la priorité 60/231,880 12.09.2000 US
Titre
(EN) Myogenic cell transfer catheter and method
(ZH) 生肌细胞输送导管和方法
Abrégé
(EN)
Catheters and methods for their use are presented that provide automated delivery of cells to structures in the body such as degenerative or weak muscle. The catheters contain one or more sensing components and a system for delivery of cells such as autologous myogenic cells. The sensing component(s) triggers automatic discharge of the cells upon detection of a body surface that needs repair. The discharge of cells may occur through an automated lancing mechanism that alleviates operator error from manual injection timing. During use, an operator can position the catheter end to a structure in need of cellular repair, and the device can automatically discharge cells at a location and time as determined by conditions sensed at the catheter end. A catheter and system is particularly useful for repair of degenerative and or weak heart muscle, such as that found after a myocardial infarct. The catheters and methods of their use also may be used for cellular repair of other interior body structures, particularly muscles such as bladder, intestine, stomach and diaphram. The catheters provide greater use of myogenic cell therapy for heart disease, while avoiding complications of open heart surgery.

(ZH)

介绍了一种导管及其使用方法,该导管将细胞自动输送到身体中的例如退化的或衰弱的肌肉结构。该导管包括一个或多个感知部件和一个用于输送细胞如自体生肌细胞的系统。在检测到一个需要修补的表面时,该感知部件触发自动排放细胞。细胞的排入可以通过一个自动刺出机构来产生,这减轻了操作者由于手动注射计时而产生的误差。在使用期间,操作者能够将导管端部安置在需要细胞修补的结构上,该装置能够在一位置上自动排放细胞,而时间由导管端部处感知的状态来决定。一种导管和系统特别适用于修补退化的或衰弱的心肌,如心肌梗死后的心肌。该导管及其使用方法也可以用于其它体内结构特别是肌肉如膀胱、肠、胃和膈的细胞修补。该导管对心脏病提供生肌细胞疗法的更多使用,而避免了切开心脏的外科手术的复杂性。