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1. CN1434875 - Method of detecting neoplastic or non-neoplastic cells

Office Chine
Numéro de la demande 01810299.9
Date de la demande 12.04.2001
Numéro de publication 1434875
Date de publication 06.08.2003
Type de publication A
CIB
C12Q 1/68
CCHIMIE; MÉTALLURGIE
12BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
QPROCÉDÉS DE MESURE OU DE TEST FAISANT INTERVENIR DES ENZYMES, DES ACIDES NUCLÉIQUES OU DES MICRO-ORGANISMES; COMPOSITIONS OU PAPIERS RÉACTIFS À CET EFFET; PROCÉDÉS POUR PRÉPARER CES COMPOSITIONS; PROCÉDÉS DE COMMANDE SENSIBLES AUX CONDITIONS DU MILIEU DANS LES PROCÉDÉS MICROBIOLOGIQUES OU ENZYMOLOGIQUES
1Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismes; Compositions à cet effet; Procédés pour préparer ces compositions
68faisant intervenir des acides nucléiques
CPC
C12Q 1/6809
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6809Methods for determination or identification of nucleic acids involving differential detection
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Déposants Monokunt Co., Ltd.
莫诺昆特股份有限公司
Inventeurs A.A. Morley
A·A·莫利
P.J. Sykes
P·J·赛克斯
M.J. Brisco
M·J·布里斯科
Mandataires cheng yong
中国国际贸易促进委员会专利商标事务所
Données relatives à la priorité PQ6876 13.04.2000 AU
Titre
(EN) Method of detecting neoplastic or non-neoplastic cells
(ZH) 检测肿瘤转化性或非肿瘤转化性细胞的方法
Abrégé
(EN)
The present invention relates to a method of qualitatively and/or quantitatively monitoring the progress of a lymphoid neoplasia in a mammal and, more particularly, to a method of monitoring the progress of a lymphoid neoplasia utilising a molecular screening technique. The method of the present invention is useful in a range of applications including, but not limited to, monitoring the progression of a neoplastic lymphoid disease condition, monitoring the levels of neoplastic lymphoid cells during remission, predicting the likelihood of a subject's relapse from a remissive state to disease state or for assessing the effectiveness of existing therapeutic drugs and/or new therapeutic agents. In a related aspect, the present invention also provides a method for qualitatively and/or quantitatively detecting clonal lymphocyte populations in a mammal and, more particularly, for detecting multiple clonal lymphocyte populations in a subject such as where a neoplastic lymphoid cell has undergone somatic gene rearrangement thereby forming a new and genetically distinct clonal population or such as where one or several clonal lymphocyte populations contribute to an immunological response.

(ZH)

本发明涉及在哺乳动物中定性和/或定量地监视淋巴肿瘤转化性进程的方法,具体地说,是用分子筛选技术监视淋巴肿瘤转化性进程的方法。本发明的方法适合于在一定的领域中应用,其包括但不限于监视肿瘤转化性淋巴疾病病情的发展,监视恢复过程中肿瘤转化性淋巴细胞的水平,预测受试者由恢复状态复发到疾病状态的可能性,或估计现有的治疗药物和/或新的治疗试剂的有效性。与此相关,本发明还提供在哺乳动物中定性和/或定量检测克隆淋巴细胞群的方法,更具体地说,是在具有下述情况的受试者中检测多克隆淋巴细胞群,即受试者中肿瘤转化性淋巴细胞已进行体细胞基因重排由此形成新的遗传上不同的克隆群,或所述受试者中一个或多个克隆群对一种免疫应答起作用。

Également publié en tant que
ININ/PCT/2002/01031/DEL