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1. CN1261793 - Sertraline salts and substained-release dosage forms of sertraline

Office Chine
Numéro de la demande 98806696.3
Date de la demande 15.06.1998
Numéro de publication 1261793
Date de publication 02.08.2000
Numéro de délivrance 1256085
Date de délivrance 17.05.2006
Type de publication C
CIB
A61K 31/135
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
13Amines, p.ex. amantadine
135ayant des cycles aromatiques, p.ex. méthadone
A61K 9/22
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
20Pilules, pastilles ou comprimés
22du type à libération prolongée ou discontinue
A61P 25/24
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
PACTIVITÉ THÉRAPEUTIQUE SPÉCIFIQUE DE COMPOSÉS CHIMIQUES OU DE PRÉPARATIONS MÉDICINALES
25Médicaments pour le traitement des troubles du système nerveux
24Antidépresseurs
CPC
A61K 9/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
A61K 9/1652
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/2009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2009Inorganic compounds
A61K 9/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Déposants Pfizer Inc.
美国辉瑞有限公司
Inventeurs Mary T. Am Ende
玛丽·T·阿姆恩德
William J. Curatolo
威廉·J·柯拉托洛
Hylar L. Friedman
海勒·L·弗里德曼
拉维·M·尚克
斯科特·M·赫比格
德韦恩·T·弗赖森
詹姆斯·B·韦斯特
Mandataires wu xiaonan
北京市柳沈律师事务所
Données relatives à la priorité 60/051,402 01.07.1997 US
60/051,414 01.07.1997 US
60/051,420 01.07.1997 US
60/051,498 01.07.1997 US
Titre
(EN) Sertraline salts and substained-release dosage forms of sertraline
(ZH) 舍曲林盐和舍曲林的缓释剂型
Abrégé
(EN)
Sustained release dosage forms of sertraline which release sertraline at a rate between 1 mgA/hr and 40 mgA/hr. The dosage forms may exhibit an initial delay period during which sertraline is released at a rate less than 1 mgA/hr. The present invention is further directed to an acetate salt, an L-lactate salt and an L-aspartate salt of sertraline, pharmaceutical compositions thereof and methods of using that salt for treating various conditions and disorders. The present invention is also directed to processes for preparing sretraline acetate, sertraline L-lactate and sertraline L-aspartate.

(ZH)

以1mgA/小时到40mgA/小时的速率释放舍曲林的舍曲林的缓释剂型。该剂型可表现出起始延迟期,在此过程中舍曲林以低于1mgA/小时的速率释放。本发明进一步的目的在于舍曲林的乙酸盐,L-乳酸盐和天冬氨酸盐,其药用组合物以及用该盐治疗各种疾病和紊乱的方法。本发明还有一个目的是制备舍曲林乙酸盐,舍曲林L-乳酸盐和舍曲林L-天冬氨酸盐的方法。