(EN) The invention discloses a molecular marker for predicting and monitoring a new coronal pneumonia course, which is hyaluronic acid or a combination containing hyaluronic acid, and other markers in thecombination comprise interleukin, D-dimer and/or C reactive protein. The invention also relates to an application of the molecular marker as a molecular marker for predicting and monitoring a new coronal pneumonia course, and an application of a detection reagent of the molecular marker in preparation of a product for predicting and monitoring the new coronal pneumonia course. The invention findsthat the level of hyaluronic acid in the plasma of a patient with severe new coronal pneumonia is remarkably increased, the level of hyaluronic acid is closely related to changes of other molecules inthe patient with new coronal pneumonia, and it is found and verified for the first time that plasma hyaluronic acid can be used as a molecular marker for distinguishing mild symptoms and severe symptoms of the patient with new coronal pneumonia; the defect of lack of effective markers for predicting and monitoring the new coronal disease course in the prior art is overcome, and treatment of new coronal pneumonia patients is facilitated.
(ZH) 本发明公开了一种新冠肺炎病程预测和监控的分子标志物，其为透明质酸或含有透明质酸的组合，所述组合中的其他标志物包括白细胞介素、D‑二聚体和/或C反应蛋白。本发明还涉及上述分子标志物作为预测和监控新冠肺炎病程的分子标志物的应用，以及上述分子标志物的检测试剂在制备预测和监控新冠肺炎病程的产品中的应用。本发明发现重症新冠肺炎患者血浆中透明质酸水平显著升高，且透明质酸水平与新冠患者中其他分子变化密切相关，且首次发现并验证可将血浆透明质酸作为区分新冠患者轻症和重症的分子标志物，从而弥补了现有技术中缺失新冠病程预测和监控的有效标志物的不足，利于进行新冠肺炎患者的救治。
