(EN) The invention provides a preparation method and an application for a gadolinium ion type contrast agent intermediate. The preparation method comprises the following steps: allowing a substance as shown in a general formula (II) which is described in the specification to react with a substance as shown in a general formula (III) which is described in the specification or a substance as shown in a general formula (IV) which is described in the specification in the presence of an alkaline catalyst so as to generate the gadolinium ion type contrast agent intermediate with a structure as shown in ageneral formula (I) or a general formula (V) which are described in the specification. In the general formulas as described in the specification, R represents a group selected from the group consisting of C1-C5 alkyl groups, benzyl groups and benzyl derivatives; R1 represents -H or -CH2OH; and R2 represents -CH3 or -OH. The above-mentioned preparation method used to prepare the gadolinium ion type contrast agent intermediate with a structure as shown in the general formula (I) which is described in the specification has the advantages of simple reaction, fewer steps and controllable reaction,and can reach a yield of 99% or above; and a product obtained by using the preparation method provided by the invention has a purity of more than 99.5%.
(ZH) 本发明提供了一种钆系离子型造影剂中间体的制备方法及应用。该制备方法包括如下步骤：通式(II)所示的物质和通式(III)所示的物质或通式(IV)所示的物质在碱性催化剂存在下，反应生成含有通式(I)或通式(V)所示结构的钆系离子型造影剂中间体；其中，R代表C1‑C5的烷基、苄基或苄基衍伸物，R1代表‑H或‑CH2OH，R2代表‑CH3或‑OH。使用上述制备方法制备含有通式(I)所示结构的钆系离子型造影剂中间体，反应简单，步骤少，反应可控，产率可达99％及以上，得到的产物的纯度大于99.5％。
