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1. CN107530417 - Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza

Office
Chine
Numéro de la demande 201580076587.7
Date de la demande 18.12.2015
Numéro de publication 107530417
Date de publication 02.01.2018
Type de publication A
CIB
A61K 39/145
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39Préparations médicinales contenant des antigènes ou des anticorps
12Antigènes viraux
145Orthomyxoviridae, p.ex. virus de l'influenza
C07K 14/005
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
14Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
005provenant de virus
CPC
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 2039/55505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55505Inorganic adjuvants
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
Déposants UNIV OREGON HEALTH & SCIENCE
SANOFI PASTEUR INC.
Inventeurs ROSS TED MILBURN
ALEFANTIS TIM
CARTER DONALD MARTIN JR
DARBY CHRISTOPHER AUSTIN
KLEANTHOUS HAROLD
Données relatives à la priorité 62/094772 19.12.2014 US
Titre
(EN) Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza
(ZH) H1N1流感的计算优化的广泛反应性抗原的协同共同给药
Abrégé
(EN)
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.

(ZH)
本发明提供计算优化的H1N1流感血凝素(HA)多肽的共同给药(例如,免疫原性合剂组合物和/或引发‑加强方案)。优化的H1N1流感血凝素(HA)多肽的共同给药促进病毒感染的协同中和,并对多样化和多种H1N1流感病毒毒株(包括季节性和大流行毒株二者)提供改进的保护性免疫(例如,广泛反应性免疫反应)。