(EN) The invention relates to antibodies directed against CD127, the alpha chain of the interleukin 7 (IL-7) receptor IL-7R), and which have antagonist properties for IL-7-IL-7R interaction, may present cytotoxic activity against CD127 positive cells but do not increase the maturation of dendritic cells (DCs) induced by TSLP, a cytokine also using CD127 as part of its receptor. Alternatively, or in addition, these antibodies do not induce the internalization of CD127 and/or inhibit the IL7-induced internalization of CD127. According to another aspect of the invention antibodies are provided which recognize a human CD127 epitope comprising sequences from the 2b site of CD127, in particular the epitope comprising comprises the human CD127 sequences of domain D1 and of the 2b site of CD127, in particular the epitope comprises at least one sequence from D1 comprising SEQ ID No: 115 (in particular comprising SEQ ID No: 10) and/or SEQ ID No: 111 and / or a sequence from the 2b site comprising the sequence of SEQ ID No: 116 and optionally also comprises SEQ ID No: 117 (in particular comprises SEQ ID No: 111).The antibodies of the invention are suitable for use inorder to remedy to a condition diagnosed in a human patient which results from pathogenesis related to lymphopoiesis, when IL-7 signalling pathways provide contribution to said pathogenesis, especially when an increase in the maturation, more precisely the upregulation of costimulatory molecules, of dendritic cells is undesirable.
(ZH) 本发明涉及抗CD127的抗体、抗白介素7(IL‑7)的受体IL‑7R的α链的抗体，其对IL‑7‑IL‑7R的相互作用具有拮抗剂性质，可能呈现针对CD127阳性细胞的细胞毒性活性而不增加TSLP诱导的树突细胞(DCs)的成熟，所述TSLP是使用CD127作为它受体一部分的细胞因子。作为另外一种选择，或此外，这些抗体不诱导CD127的内化和/或抑制IL7‑诱导的CD127的内化。根据本发明的另一方面，提供能够识别以下表位的抗体：含有源自CD127的2b位点的序列的人CD127表位，特别是含有包括CD127的D1结构域和2b位点的人CD127序列的表位，特别是含有至少一个源自D1的序列和/或源自2b位点的序列以及可选地也包括SEQ ID No：117(特别是包括SEQ ID No：111)的表位，所述源自D1的序列包括SEQ ID No：115(特别是含有SEQ ID No：110)和/或SEQ ID No：111，所述源自2b位点的序列包括SEQ ID No：116的序列。当IL‑7信号通路对所述发病机理提供贡献时，特别是不期望树突细胞的成熟增加时，更精确地说不期望树突细胞的共刺激分子上调时，本发明的抗体适于用于救治患者诊断的病况，所述病况是由与淋巴细胞生成相关的发病机理导致的。
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