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1. (CA2552050) HETEROCYCLES SUBSTITUES ET UTILISATIONS ASSOCIEES
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CLAIMS:
1. A compound of general formula (II), or a pharmaceutically acceptable salt thereof:
wherein:
R1 is phenyl optionally substituted on one or more carbon atoms by one or more R9, wherein R9 is a halogen atom, amino, C1-6alkyl or C1-6alkoxy;
one of R2 and R3 is C(=O)NHR7 and the other is -NHC(=O)NH2; and R7 is piperidin-3-yl.
2. A compound, or a pharmaceutically acceptable salt thereof, according to claim 1, wherein R2 is -NHC(=O)NH2 and R3 is -C(=O)NHR7.
3. 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid (S)-piperidin3-ylamide or a pharmaceutically acceptable salt thereof.
4. 5-Phenyl-2-ureido-thiophene-3-carboxylic acid (S)-piperidin-3ylamide or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound of any one of claims 1 to 4, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier, diluent or excipient.
6. A pharmaceutical composition comprising a compound of claim 3 or 4, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier, diluent or excipient.
7. An intermediate compound of general formula (XI) and a salt thereof:
wherein R1 and R7 are as defined in claim 1.
8. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the treatment or prophylaxis of a disorder associated with cancer.
9. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the preparation of a medicament for the treatment or prophylaxis of
disorder associated with cancer.
10. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the treatment or prophylaxis of a neoplastic disease.
11. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the preparation of a medicament for the treatment or prophylaxis of
neoplastic disease.
12. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in limiting cell proliferation in a human or animal.
13. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the preparation of a medicament for limiting cell proliferation in a human or an animal.
14. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the prophylaxis or treatment of a human or animal suffering from cancer.
15. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the preparation of a medicament for the prophylaxis or treatment of
human or animal suffering from cancer.
16. The compound, salt or composition as claimed in claim 14 or 15, wherein the use is combined with an antitumor agent.
17. The compound, salt or composition as claimed in claim 14 or 15, wherein the use is combined with a DNA damaging agent.
18. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in inhibiting CHK1 kinase.
19. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the preparation of a medicament for inhibiting CHK1 kinase.
20. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in the preparation of a medicament for the inhibition of CHK1 kinase activity.
21. A compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or
for use in inhibiting CHK1 kinase activity.
22. Use of a compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, or a composition as claimed in claim 5 or 6, wherein the use is as defined in any one of claims 8 to 21.
23. A commercial package comprising a compound, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to
or a composition as claimed in claim 5 or 6, and associated therewith instructions for the use thereof as defined in any one of claims 8, 10, 12, 14, 16, 17, 18 and 21.