AU2007239354 N protein fusion proteins of a virus in the Paramyxoviridae-protein of interest family

Office

Australie

Numéro de la demande 2007239354

Date de la demande 18.04.2007

Numéro de publication 2007239354

Date de publication 13.11.2008

Type de publication B2

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Déposants Institut National de la Recherche Agronomique (INRA)

Inventeurs Eleouet, Jean-Francois
Riffault, Sabine

Mandataires Davies Collison Cave Pty Ltd

Données relatives à la priorité 0603410 18.04.2006 FR

Titre

(EN) N protein fusion proteins of a virus in the Paramyxoviridae-protein of interest family

Abrégé

(EN) The invention relates to N protein fusion proteins of interest, possibly in the form of N protein protein of interest/P protein soluble complexes, the N and P proteins being proteins of a virus in the Paramyxoviridae family. When the protein of interest is an antigen, the invention also relates to vaccine compositions and reagents of the diagnostic comprising these N protein-antigen fusion proteins or these N protein-antigen/P protein complexes. The N protein-protein of interest fusion may also be used as a 'vector' to transport therapeutic molecules of interest in the cells, such as antiviral or anticancer molecules.

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C	CHIMIE; MÉTALLURGIE
12	BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
N	MICRO-ORGANISMES OU ENZYMES; COMPOSITIONS LES CONTENANT; CULTURE OU CONSERVATION DE MICRO-ORGANISMES; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE; MILIEUX DE CULTURE
15	Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci
09	Technologie d'ADN recombinant
11	Fragments d'ADN ou d'ARN; Leurs formes modifiées
62	Séquences d'ADN codant pour des protéines de fusion

A	NÉCESSITÉS COURANTES DE LA VIE
61	SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K	PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39	Préparations médicinales contenant des antigènes ou des anticorps
12	Antigènes viraux
155	Paramyxoviridae, p. ex. virus de para-influenza

C	CHIMIE; MÉTALLURGIE
07	CHIMIE ORGANIQUE
K	PEPTIDES
14	Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
005	provenant de virus
08	Virus à ARN
115	Paramyxoviridae, p. ex. virus para-influenza

C	CHIMIE; MÉTALLURGIE
07	CHIMIE ORGANIQUE
K	PEPTIDES
14	Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
005	provenant de virus
08	Virus à ARN
115	Paramyxoviridae, p. ex. virus para-influenza
135	Virus respiratoire syncytial

C	CHIMIE; MÉTALLURGIE
12	BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
N	MICRO-ORGANISMES OU ENZYMES; COMPOSITIONS LES CONTENANT; CULTURE OU CONSERVATION DE MICRO-ORGANISMES; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE; MILIEUX DE CULTURE
15	Techniques de mutation ou génie génétique; ADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purification; Utilisation d'hôtes pour ceux-ci
09	Technologie d'ADN recombinant
11	Fragments d'ADN ou d'ARN; Leurs formes modifiées
31	Gènes codant pour des protéines microbiennes, p. ex. entérotoxines
33	Gènes codant pour des protéines virales
40	Protéines de virus à ARN, p. ex. flavivirus
45	Paramyxoviridae, p. ex. virus de la rougeole, virus des oreillons, virus de la maladie de Newcastle, virus de la maladie de Carré, virus de la peste bovine, virus respiratoires syncytiaux

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30. AU2007239354 - N protein fusion proteins of a virus in the Paramyxoviridae-protein of interest family

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
51	comprising whole cells, viruses or DNA/RNA
525	Virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005	from viruses

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2760	ssRNA Viruses negative-sense
00011	ssRNA Viruses negative-sense
18011	Paramyxoviridae
18022	New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04	Antibacterial agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
646	the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
646	the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines