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Paramétrages

Paramétrages

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1. WO2000034473 - DOMAINE TRANSMEMBRANAIRE 7 ZSIG56

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

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CLAIMS

What is claimed is:

1. An isolated polynucleotide molecule that encodes a polypeptide selected from the group consisting of:

a) a polypeptide comprising amino acid residues 1 to 693 of SEQ ID NO:2;

b) a polypeptide comprising amino acid residues 26 to 693 of SEQ ID NO:2;

c) a polypeptide comprising amino acid residues 109 to 693 of SEQ ID NO:2;

d) a polypeptide comprising amino acid residues 182 to 693 of SEQ ID NO:2;

e) a polypeptide comprising amino acid residues 282 to 693 of SEQ ID NO:2;

f) a polypeptide comprising amino acid residues 288 to 693 of SEQ ID NO:2;

g) a polypeptide comprising amino acid residues 372 to 693 of SEQ ID NO:2;

h) degenerate polynucleotide sequence of a), b), c), d), e), f ) or g); and

l) polynucleotide sequence complementary to a), b), c), d), e), f), g) or h) .

2). An isolated polynucleotide molecule according to claim 1, wherein said polynucleotide is selected from the group consisting of:

a) nucleotides 190-2268 of SEQ ID NO:1;

b) nucleotides 514-2268 of SEQ ID NO:1;

c) nucleotides 733-2268 of SEQ ID NO:1;

d) nucleotides 1033-2268 of SEQ ID NO:1; e) nucleotides 1051-2268 of SEQ ID NO:1; f) nucleotides 1293-2268 of SEQ ID NO:1;

g) nucleotides 265-2268 of SEQ ID NO:1; h) a degenerate polynucleotide sequence of a), b), c), d), e), f) or g);; and

i) a polynucleotide sequence complementary to a), b), c), d), e), f), g) or h).

3. An expression vector comprising the following operably linked elements:

a transcription promoter;

a polynucleotide molecule according to claim 1; and a transcription terminator.

4. An expression vector according to claim 3 further comprising a secretory signal sequence operably linked to said polynucleotide molecule.

5. A cultured cell into which has been introduced an expression vector according to claim 3, wherein said cultured cell expresses said polypeptide encoded by said polynucleotide segment.

6. A method of producing a polypeptide comprising: culturing a cell into which has been introduced an expression vector according to claim 3;

whereby said cell expresses said polypeptide encoded by said polynucleotide molecule; and

recovering said expressed polypeptide.

7. An isolated polypeptide selected from the group consisting of:

a) a polypeptide comprising amino acid residues 1 to 25 of SEQ ID NO: 2;

b) a polypeptide comprising amino acid residues 109 to 693 of SEQ ID NO:2;

c) a polypeptide comprising amino acid residues 182 to 693 of SEQ ID NO:2;

d) a polypeptide comprising amino acid residues 282 to 693 of SEQ ID NO:2;

e) a polypeptide comprising amino acid residues 288 to 693 of SEQ ID NO:2;

f) a polypeptide comprising amino acid residues 372 to 693 of SEQ ID NO:2;

g) a polypeptite comprising amino acid residues 26 to 693 of SEQ ID NO:2; and

h) a polypeptide molecule having the sequence of SEQ ID NO:2.

8. A polypeptide selected from the group consisting of:


9. An antibody or antibody fragment that specifically binds to a polypeptide according to claim 7.

10. An antibody according to claim 9, wherein said antibody is selected from the group consisting of:

a) polyclonal antibody;

b) murine monoclonal antibody;

c) humanized antibody derived from b); and d) human monoclonal antibody.

11. An antibody fragment according to claim 9, wherein said antibody fragment is selected from the group consisting of F(ab'), F(ab), Fab', Fab, Fv, scFv, and minimal recognition unit.

12. An anti-idiotype antibody that specifically binds to said antibody of claim 9.