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1. WO2019109122 - PROCÉDÉS BASÉS SUR UN COMPORTEMENT DE FILM LACRYMAL

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

CLAIMS

1 . A method of diagnosing, or developing or monitoring a treatment regime for, an ocular condition in a subject based on detected physical behaviour in a tear film, or lack of tear film, in the subject’s eye, the method comprising the steps of:

a. capturing from the subject’s eye at least a first captured data set; b. analysing the at least a first captured data set and thereby detecting

physical behaviour in the tear film; and

c. diagnosing, or developing or monitoring a treatment regime for, the ocular condition based on the detected physical behaviour of the tear film.

2. A method of diagnosing, or developing or monitoring a treatment regime for, an ocular condition in a subject based on detected physical behaviour in a tear film, or lack of tear film, in the subject’s eye, the method comprising the steps of:

a. capturing from the subject’s eye at least a first captured data set; b. identifying at least a first comparative data set;

c. analysing the at least a first captured data set relative to the at least a first comparative data set, thereby detecting physical behaviour in the tear film; and

d. diagnosing, or developing or monitoring a treatment regime for, the ocular condition based on the detected physical behaviour of the tear film.

3. The method of claim 1 or 2, wherein the detected physical behaviour is defined by one or more characteristics of the tear film, or lack of tear film, selected from the group consisting of: shape, size, and position.

4. The method of claim 2 or 3 wherein detection of the physical behaviour is achieved at a macroscopic level.

5. The method of any one of claims 1 to 4, wherein the step of capturing is achieved by one or more mode selected from the group consisting of: observing, monitoring, and/or recording.

6. The method of any one of claims 1 to 5, wherein the first captured data set

includes data reflecting detected physical behaviour of a tear film, or lack of tear film, in the subject’s eye identified at a first predetermined time and/or over a predetermined period of time or a plurality of predetermined times.

7. The method of claim 6 wherein the first predetermined time for identifying a

detected physical behaviour is between about 1x1 O 2 and about 2x1 O 1 seconds following commencement of the step of capturing.

8. The method of any one of claims 1 to 7, wherein the capturing step further

includes capturing at least a second captured data set.

9. The method of claim 8 wherein the second captured data set includes data

reflecting detected physical behaviour of a tear film, or lack of tear film, in the subject’s eye identified at a second predetermined time and/or at a further plurality of predetermined times.

10. The method of claim 9 wherein the second predetermined time for identifying a detected physical behaviour is between about 2x1 O 2 and about 2x10_1 seconds following the first predetermined time.

1 1.The method of claim 9 wherein the second predetermined time for identifying a detected physical behaviour is between about 6 months and about one year following the first predetermined time.

12. The method of any one of claims 9 to 11 wherein the further plurality of

predetermined times occurs about monthly, quarterly, or annually, after the second predetermined time.

13. The method of any one of claims 6 to 12 wherein the first captured data set or one or more further captured data set/s include/s data reflecting detected physical behaviour of a tear film, or lack of tear film, in the subject’s eye identified over a predetermined period of time, which period, following commencement of the step of capturing, is selected from the group consisting of: about 0.00 to about 1.00 second, about 0.00 to about 3.00 seconds, about 0.00 to about 6.00 seconds, about 0.00 to about 10.00 seconds, about 0.00 to about 15.00 seconds,

about 0.00 to about 30.00 seconds, about 1.00 to about 7.00 seconds, about 3.00 to about 12.00 seconds, and about 6.00 to about 20.00 seconds.

14. The method of claim 13 wherein the predetermined period of time is a length of time for which the subject can maintain a sustained opening of the eye.

15. The method of any one of claims 1 to 14, wherein the step of capturing

commences between about 0.00 and 1x1 O 2 seconds following the eye blinking.

16. The method of claim 15 wherein the blink is selected from the group consisting of: a natural unforced blink, a hard blink, and a blink using an intermediate level of force.

17. The method of any one of claims 2 to 16, wherein the step of identifying is

achieved by referencing from at least a predetermined knowledge base, and/or observing, monitoring, measuring and/or recording from a predetermined source.

18. The method of claim 17 wherein the predetermined knowledge base includes information based on training, study and/or experience of a person in relation to detected physical behaviour in a tear film, or lack of tear film, in a subject’s eye, which person is undertaking the diagnosis of, or development or monitoring of a treatment regime for, an ocular condition in the subject.

19. The method of claim 17 or 18, wherein the predetermined source includes one or more data sets from the group consisting of:

a. any second of further captured data set, and/or

b. one or more data sets from the group consisting of photographs, video footage, medical or scientific imaging, and/or diagrams relating to detected physical behaviour in a tear film, or lack of tear film, in the subject’s or other subjects’ eyes.

20. The method of any one or more of claims 1 to 19, wherein the step of analysing includes evaluating the at least a first captured data set relative to the at least a first comparative data set to identify at least a first set of diagnostic

characteristics.

21 .The method of claim 20 wherein the at least a first set of diagnostic

characteristics is selected from the group consisting of: absence or presence of a possible ocular condition, differential diagnosis for a possible ocular condition, relative suitability of an ocular orthosis, relative efficacy of a treatment regime, and/or relative merit in maintaining, varying or ceasing a current treatment regime.

22. The method of claim 20 or 21 , wherein the step of diagnosing the ocular

condition includes making a diagnosis based on the at least a first set of diagnostic characteristics.

23. The method of any one of claims 20 to 22, wherein the step of developing or monitoring a treatment regime for an ocular condition in the subject includes developing or monitoring the treatment regime based on the at least a first set of diagnostic characteristics.

24. The method of any one of claims 21 to 23, wherein the ocular orthosis is an

ocular device or a contact lens and developing or monitoring a treatment regime includes trialling different makes/models of contact lenses for the subject’s eye or eyes.

25. The method of any one of claims 1 to 24 is conducted in real time.

26. The method of any one of claims 1 to 25, wherein the step of capturing includes capturing the at least a first captured data set using a video camera.

27. The method of claim 26 wherein the video camera is infrared sensitive.

28. The method of any one of claims 1 to 27, wherein the ocular condition is selected from one or more ocular conditions in the group consisting of: dry eye syndrome, aqueous deficient dry eye, evaporative dry eye, keratoconjunctivitis sicca, keratoconus, Meibomian gland disorders, tear duct disorders, Sjogren's syndrome, corneal scarring, Behcet’s Disease, normal tear film, incomplete

blinking, eye disease associated with rheumatoid arthritis, eye disease associated with connective tissue disorders, permanent or temporary closure of tear ducts, and cosmetic variations.

29. The method of claim 27 or 28, wherein the infrared sensitive camera comprises:

a. means to detect infrared wavelengths in a range of about 1.5 pm to about 14 pm;

b. means to record frame rate data above 10Hz;

c. means to set pitch resolution at or below 35pm;

d. means to detect spectral response data at a spatial resolution above

about 320x240 pixels; and

e. a software program adapted to interpret the wavelength data, frame rate data, pitch resolution, and spatial resolution data, such that differentials in emissivity between components of the subject’s eye tear film is depicted in an observable form.

30. A method of selecting a contact lens for a subject, the method comprising:

a. capturing from a first eye of the subject a first captured data set, the first captured data set including detected physical behaviour of the tear film in the first eye;

b. identifying a first test contact lens and having the first test contact lens instilled in the first eye;

c. after a predetermined or preferred first period of time, capturing from the first eye a second captured data set, the second captured data set

including detected physical behaviour of the tear film of the first eye with the first test contact lens instilled;

d. analysing the second captured data set relative to the first captured data set and/or a comparative data set; and

e. evaluating the relative suitability of the first test contact lens to be selected as the contact lens for the subject.

31.The method of claim 30, further including, after a predetermined or preferred second period of time, capturing from the first eye a third captured data set, the third captured data set including detected physical behaviour of the tear film of the first eye after the first test contact lens has been removed following an instilled period.

32. The method of claim 30 or 31 , wherein predetermined or preferred first period of time commences immediately following instillation of the first test contact lens and ends following initial tearing has subsided.

33. The method of claim 32, wherein the predetermined or preferred first period of time is at least about 3 to about 5 minutes.

34. The method of claim 30 or 31 , wherein the predetermined or preferred first period of time is selected from about 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 24 hours, or longer.

35. The method of any one of claims 30 to 34, conducted for the second eye of the subject using a corresponding first test contact lens and/or a different test contact lens.

36. The method of any one of claims 30 to 35 repeated for a second test contact lens.

37. The method of claim 36 repeated for one or more further test contact lens.

38. The method of claim 35 or 36, repeated for a corresponding second test contact lens or further different contact lens.

39. The method of any one of claims 30 to 38 wherein the method is performed on both of the subject’s eyes simultaneously or substantially simultaneously.

40. The method of any one of claims 31 to 39, wherein a contact lens suitable for selection is one the removal of which allows the detected physical behaviour of a tear film to show detected physical behaviour substantially consistent with immediate re-establishment of a normal tear film.

41 .The method of any one of claims 31 to 39, wherein a contact lens suitable for selection is one the removal of which allows the detected physical behaviour of the tear film to be close to undisrupted or only mildly disrupted, with re- establishment of normalcy in a relatively short period of time.

42. The method of claim 41 wherein the relatively short period of time is less than about 3 minutes.

43. The method of any one of claims 31 to 42 wherein the installed time is from

about 10 minutes to about 1 hour or longer.

44. The method of any one of claims 30 to 43, wherein a contact lens suitable for selection is one which results in a detected physical behaviour of a normal tear film initially on instillation of the contact lens and then continuing over time or one which does not result in a change in the detected physical behaviour of the tear film from before the fitting the contact lens.

45. The method of any one of claims 30 to 39, wherein a contact lens less preferred for selection is one which does not allow the detected physical behaviour of the tear film to show normal formation of a normal tear film initially following instillation, but allows the detected physical behaviour of the tear film to show either a complete or partial tear film formation over time.

46. The method of any one of claims 30 to 39, wherein a contact lens preferred to be excluded from selection is one which results in the detected physical behaviour of a tear film appearing normal initially and then deteriorating over time.

47. The method of any one of claims 30 to 39, wherein a contact lens preferred to be excluded from selection is one for which the detected physical behaviour of tear film appears disrupted initially and remains disrupted over time.

48. The method of any one of claims 30 to 47 repeated for a plurality of test contact lenses so as to select a contact lens for a subject.

49. The method of any one of claims 35 to 48 repeated for a plurality of

corresponding test contact lenses and/or for a plurality of further different contact lenses so as to select a corresponding contact lens and/or a further different contact lens for a subject.

50. A contact lens selected according to the method of any one of claims 30 to 49.