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Paramétrages

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1. WO2011061498 - SOLUTIONS D'INHALATION

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[ EN ]

CLAIMS:

1. An inhaler for an inhalation formulation, comprising a canister containing a pharmaceutical composition under pressure; a metering valve for measuring a metered dose of the composition from the canister for administration to a patient in need thereof; and an actuator for actuating discharge of the metered dose to the patient; wherein the actuator includes a discharge orifice having a diameter in the range 0.2 to 0.4 mm; and wherein the pharmaceutical composition comprises an anticholinergic agent and a pharmaceutically acceptable propellant.

2. An inhaler according to claim 1, wherein the anticholinergic is selected from tiotropium, ipratropium, oxitropium, aclidinium, their pharmaceutically acceptable salts or solvates, and mixtures thereof.

3. An inhaler according to claim 1 or 2, wherein the anticholinergic agent is tiotropium bromide.

4. An inhaler according to claim 1, 2, or 3, wherein the metering valve is configured to dispense the metered dose of the pharmaceutical composition containing 2.5 to 18 micrograms of the or each anticholinergic agent.

5. An inhaler according to any preceding claim, wherein the propellant includes one or more pharmaceutically acceptable HFC propellants, and/or one or more pharmaceutically acceptable hydrocarbon propellants.

6. An inhaler according to any preceding claim, wherein the composition further includes a co-solvent, which is preferably a polar co-solvent.

7. An inhaler according to claim 6, where the co-solvent comprises one or more

C2-6 aliphatic alcohols and/or polyols.

8. An inhaler according to any preceding claim, wherein the pharmaceutical composition further comprises one or more beta adrenergic agents

9. An inhaler according to any preceding claim, where in pharmaceutical composition 5 further comprises one or more corticosteroids.

10. An inhaler for an inhalation formulation, comprising a canister containing a pharmaceutical composition under pressure; a metering valve for measuring a metered dose of the composition from the canister for administration to a patient in need thereof; and an

10 actuator for actuating discharge of the metered dose to the patient; wherein the actuator includes a discharge orifice having a diameter in the range 0.2 to 0.4 mm; and wherein the pharmaceutical composition comprises a tiotropium or a salt thereof, one or more pharmaceutically acceptable HFC propellants, and/or one or more pharmaceutically acceptable hydrocarbon propellants, and one or more pharmaceutically acceptable excipients.

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11. An inhaler according to claim 10, wherein the pharmaceutical composition further comprises one or more beta adrenergic agents

12. An inhaler according to claim 10 or 11, where in pharmaceutical composition further 20 comprises one or more corticosteroids.

13. The use of an inhaler as claimed in any preceding claim in the treatment of a respiratory disorder

25 14. The use of an inhaler as claimed in any one of claims 1 to 12, in the treatment of asthma and/or a chronic obstructive pulmonary disease.

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