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1. WO2019077331 - COMPOSÉS COUMARINES SUBSTITUES PAR UNE AMINE SECONDAIRE ET LEURS UTILISATIONS EN TANT QUE MARQUEURS FLUORESCENTS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/GB2018/052971 P197717.WO.01
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
16 October 2018 16 October 2017
Applicant
ILLUMINA CAMBRIDGE LIMITED
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 405/04 (2006.01)i; C07D 413/04 (2006.01)i; C07D 417/04 (2006.01)i; C07F 9/44 (2006.01)i; C12Q 1/68 (2018.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D; C07F; C12Q
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X,P
WO 2018060482 A1 (ILLUMINA CAMBRIDGE LTD [GB]) 05 April 2018 (2018-04-05)
1-64
example 3, claims
(2)
X
PAUL KAMALDEEP ET AL, "Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL,Vol. 23, No. 12, 04 January 2013 (2013-01-04), page 3667-3672,
XP028543371
1-3,6-8,12-16,18-25,27,32,34-36,38,39,42,44,45
compounds 7-11 and 18
(3)
X
US 2013059321 A1 (DAVIES KELVIN J A [US] ET AL) 07 March 2013 (2013-03-07)
1-3,5-8,12-16,18-28,32-36,38,39,41,42,44,45,47-64
Whole document, specially compound (9), p. 5
(4)
A
L. WU ET AL, "The Structure and Pharmacological Functions of Coumarins and Their Derivatives", CURRENT MEDICINAL CHEMISTRY,Vol. 16, No. 32, 01 November 2009 (2009-11-01), page 4236-4260,
XP055524929
1-64
the whole document
(5)
X
R. Srinnasan ET AL, "Volume 25, number 4 ANOMALOUS FLUORESCENCE AND LASER EMISSION FROif 7-ALKYLAMINO COUMARINS IN ACID SOLUTIONS", 15 April 1974 (1974-04-15),
Retrieved from the Internet:
URL:https://ac.els-cdn.com/0009261474853613/1-s2.0-0009261474853613-main.pdf?_tid=152f8d3d-f5c2-4cf5-8708-118645649b68&acdnat=1542636094_511ad87bbb85fd464bf0d7a5f6a73552
XP055524937
1-3,5,7,12-16,18-22,24,27,32,33,35,36,42,44,45
Compounds IIIa and IIIb in p. 540
(6)
X
CN 103740136 B (ZHEJIANG LONGSHENG GROUP CO) 06 January 2016 (2016-01-06)
1
compound (V-4) in p. 8; formula (V) in claim 2
(7)
X
JP 2005007851 A (FUJI PHOTO FILM CO LTD) 13 January 2005 (2005-01-13)
1-3,5,12-16,18-25,27
compound FL-4 in p. 8 and Formula 1
(8)
X
JP 2002278066 A (MITSUBISHI PAPER MILLS LTD) 27 September 2002 (2002-09-27)
1-3,5,7,12-16,19-25,27,32,33,35,36,38,39,42,44,45
compound 20 in paragraph [0074]
(9)
X
EP 0730007 A2 (BAYER AG [DE]) 04 September 1996 (1996-09-04)
1,3,5,12-16,19,21,24,25,27
third compound in p. 17 and formula (IV) in claim 5
(10)
X
JP H0743896 A (TOYO BOSEKI) 14 February 1995 (1995-02-14)
32,33,35,36,38,39,42-45
compound D-3 in p. (3)
(11)
X
JP H05263072 A (MITSUI TOATSU CHEM INC, PIONEER ELECTRONIC CORP) 12 October 1993 (1993-10-12)
1-3,5-8,12-16,19-25,27,32-36,38,39,42
compounds 5, 8, 9 in p. (5), compounds 14, 16, 18, 20 in p. (7)
(12)
X
EP 0608737 A1 (BAYER AG [DE]) 03 August 1994 (1994-08-03)
1-64
Whole document, specially claim 2 and examples
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2018060482 A1
05 April 2018
US 2018094140 A1
WO 2018060482 A1
05 April 2018
05 April 2018
US 2013059321 A1
07 March 2013
NONE
CN 103740136 B
06 January 2016
NONE
JP 2005007851 A
13 January 2005
NONE
JP 2002278066 A
27 September 2002
JP 4143270 B2
JP 2002278066 A
03 September 2008
27 September 2002
EP 0730007 A2
04 September 1996
CN 1137548 A
DE 19509043 A1
DE 59605771 D1
EP 0730007 A2
JP H08245540 A
TW 410219 B
US 5750761 A
11 December 1996
05 September 1996
28 September 2000
04 September 1996
24 September 1996
01 November 2000
12 May 1998
JP H0743896 A
14 February 1995
NONE
JP H05263072 A
12 October 1993
JP 2999841 B2
JP H05263072 A
17 January 2000
12 October 1993
EP 0608737 A1
03 August 1994
DE 4302459 A1
EP 0608737 A1
JP 3887786 B2
JP H06271599 A
US 5547860 A
04 August 1994
03 August 1994
28 February 2007
27 September 1994
20 August 1996
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 November 2018
Date of mailing of the international search report:
28 November 2018
Authorized officer:
Sahagún Krause, H
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