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International application No. Applicant's or agent's file reference
PCT/US2020/016194 008073-5207-WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
31 January 2020 01 February 2019
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61K 38/36 (2006.01)i; A61K 38/37 (2006.01)i; A61P 7/04 (2006.01)i; C07K 14/745 (2006.01)i; C07K 14/755 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     A61K; C07K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
US 2012316116 A1 (SCHEIFLINGER FRIEDRICH [AT] ET AL) 13 December 2012 (2012-12-13)
paragraphs [0205], [0137], [0316], [0335]; claims 1-31; examples 1-5
T. ABSHIRE ET AL, "Prophylaxis escalation in severe von Willebrand disease: a prospective study from the von Willebrand Disease Prophylaxis Network", JOURNAL OF THROMBOSIS AND HAEMOSTASIS,Vol. 13, No. 9, 14 July 2015 (2015-07-14), page 1585-1589,
JOAN C GILL ET AL, "Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease", BLOOD,22 October 2015 (2015-10-22),
page 2039, right-hand column, paragraph 4
Anonymous, "rVWF IN PROPHYLAXIS - Full Text View -", 06 March 2018 (2018-03-06),
Retrieved from the Internet:
[retrieved on  2020-05-20]
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
US 2012316116 A1
13 December 2012
AR 086904 A1
AU 2012267458 A1
AU 2016202299 A1
AU 2017206235 A1
AU 2020200026 A1
BR 112013031795 A2
CA 2838845 A1
CN 103732244 A
CN 107412743 A
CN 108210889 A
DK 2717905 T3
EP 2717905 A1
EP 3412305 A1
ES 2682249 T3
HR P20180962 T1
HU E039317 T2
JP 6347468 B2
JP 6527114 B2
JP 2014516088 A
JP 2017019788 A
JP 2019048892 A
KR 20140039285 A
KR 20190041032 A
LT 2717905 T
MX 350582 B
NZ 618790 A
PL 2717905 T3
PT 2717905 T
RU 2014100107 A
RU 2017102679 A
SG 10201604684W A
SI 2717905 T1
TR 201808823 T4
US 2012316116 A1
US 2016184403 A1
WO 2012171031 A1
29 January 2014
09 January 2014
05 May 2016
03 August 2017
30 January 2020
20 December 2016
13 December 2012
16 April 2014
01 December 2017
29 June 2018
02 July 2018
16 April 2014
12 December 2018
19 September 2018
19 October 2018
28 December 2018
27 June 2018
05 June 2019
07 July 2014
26 January 2017
28 March 2019
01 April 2014
19 April 2019
10 October 2018
11 September 2017
31 July 2015
31 October 2018
02 July 2018
20 July 2015
19 December 2018
28 July 2016
28 September 2018
23 July 2018
13 December 2012
30 June 2016
13 December 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 May 2020
Date of mailing of the international search report:
03 June 2020
Authorized officer:
Habedanck, Robert
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