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1. WO2020157760 - NÉO-ANTIGÈNES CRÉÉS PAR ÉPISSAGE ABERRANT INDUIT ET LEURS UTILISATIONS DANS L'AMÉLIORATION DE L'IMMUNOTHÉRAPIE


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/IL2020/050119 2690533-JDB
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
30 January 2020 31 January 2019
Applicant
BAR ILAN UNIVERSITY
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12N 15/113 (2010.01)i; C12N 15/11 (2006.01)i; A61K 31/7088 (2006.01)i; A61K 39/00 (2006.01)i; A61P 35/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12N; A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, Sequence Search, EMBASE, EMBL, CHEM ABS Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2014068063 A1 (BAUER JOHANN [AT]) 08 May 2014 (2014-05-08)
1-6,8-10,14-17,19-22,24,25,28,30-37,39,40,44,46-53,56-64
claims 1-10,15-18; examples 2-5
(2)
X
WO 2016142948 A1 (YISSUM RES DEV CO [IL]) 15 September 2016 (2016-09-15)
1-6,8-11,13-17,19-22,24,25,27-37,39-41,43-53,55-64
page 39; claims 1-9,18-22; figures 1,2,6; examples 1-5
(3)
Y
GIOVANNI GERMANO ET AL, "Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth", NATURE,Vol. 552, No. 7683, 07 December 2017 (2017-12-07), page 116-120,
XP055594122
1-65
page 116; figure 3
(4)
Y
WO 2018122610 A1 (OLIPASS CORP [KR]) 05 July 2018 (2018-07-05)
12,26,42
claims 1,8-14; example 1
(5)
X
REYKA G. JAYASINGHE ET AL, "Systematic Analysis of Splice-Site-Creating Mutations in Cancer", CELL REPORTS,Vol. 23, No. 1, 03 April 2018 (2018-04-03), page 270-281.e3,
XP055680502
65
page 277; figures 1,2
(6)
Y
WO 2017112956 A1 (MOONSHOT PHARMA LLC [US]) 29 June 2017 (2017-06-29)
1-65
claims 1,2,27
(7)
A
WO 2017106638 A1 (GRITSTONE ONCOLOGY INC [US]) 22 June 2017 (2017-06-22)
1-65
claims 1,50,51
(8)
A
ANDRÉ KAHLES ET AL, "Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients", CANCER CELL,Vol. 34, No. 2, 02 August 2018 (2018-08-02), page 211-224.e6,
XP055680484
1-65
figures 1,5
(9)
A
ALICIA C SMART ET AL, "Intron retention is a source of neoepitopes in cancer", NATURE BIOTECHNOLOGY,Vol. 36, No. 11, 16 August 2018 (2018-08-16), page 1056-1058,
XP055680534
1-65
figures 1,2
(10)
A
ORNELLA FRANZESE ET AL, "Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors", ONCOTARGET,Vol. 8, No. 25, 17 March 2017 (2017-03-17), page 41641-41669,
XP055618024
1-65
figure 3
(11)
A
GILBOA ELI, "Expression of new antigens on tumor cells by inhibiting nonsense-mediated mRNA decay", 06 November 2013 (2013-11-06), Vol. 57, No. 1, page 44-51,
XP035952302
[retrieved on  2013-11-06]
1-65
figure 4
(12)
A
TIFFANY WILLIAMS ET AL, "Analysis of Prostate-Specific Membrane Antigen Splice Variants in LNCap Cells", OLIGONUCLEOTIDES.,Vol. 16, No. 2, 09 June 2006 (2006-06-09), page 186-195,
XP055684939
1-65
figures 1-3
(13)
E
WO 2020043750 A1 (ROCHE INNOVATION CT COPENHAGEN AS [DK]) 05 March 2020 (2020-03-05)
1-65
the whole document
(14)
X,P
WO 2019040664 A1 (SALK INST FOR BIOLOGICAL STUDI [US]) 28 February 2019 (2019-02-28)
1-65
example 13
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2014068063 A1
08 May 2014
EP 2914721 A1
ES 2652143 T3
JP 6608284 B2
JP 2015534811 A
PL 2914721 T3
US 2015250901 A1
WO 2014068063 A1
09 September 2015
31 January 2018
20 November 2019
07 December 2015
29 June 2018
10 September 2015
08 May 2014
WO 2016142948 A1
15 September 2016
EP 3268475 A1
US 2017327825 A1
WO 2016142948 A1
17 January 2018
16 November 2017
15 September 2016
WO 2018122610 A1
05 July 2018
AU 2017385962 A1
BR 112019011692 A2
CA 3046904 A1
CN 110506051 A
EP 3562836 A1
JP 2020504757 A
KR 20190093225 A
US 2019337987 A1
WO 2018122610 A1
27 June 2019
22 October 2019
05 July 2018
26 November 2019
06 November 2019
13 February 2020
08 August 2019
07 November 2019
05 July 2018
WO 2017112956 A1
29 June 2017
CA 3048193 A1
CA 3048202 A1
CA 3048204 A1
EP 3405190 A1
EP 3405478 A1
EP 3405587 A1
JP 2019502753 A
JP 2019505578 A
JP 2019505579 A
US 2019083489 A1
US 2019350908 A1
US 2019388400 A1
WO 2017112954 A1
WO 2017112955 A1
WO 2017112956 A1
29 June 2017
29 June 2017
29 June 2017
28 November 2018
28 November 2018
28 November 2018
31 January 2019
28 February 2019
28 February 2019
21 March 2019
21 November 2019
26 December 2019
29 June 2017
29 June 2017
29 June 2017
WO 2017106638 A1
22 June 2017
AU 2016369519 A1
BR 112018012374 A2
CA 3008641 A1
CN 108601731 A
CO 2018007417 A2
EP 3389630 A1
JP 2019501967 A
KR 20180107102 A
PE 20181535 A1
PH 12018501267 A1
RU 2018124997 A
SG 11201804957V A
TW 201733598 A
US 2017199961 A1
US 2017212984 A1
US 2018330055 A1
US 2019034585 A1
US 2019065675 A1
WO 2017106638 A1
12 July 2018
04 December 2018
22 June 2017
28 September 2018
28 September 2018
24 October 2018
24 January 2019
01 October 2018
26 September 2018
11 February 2019
16 January 2020
30 July 2018
01 October 2017
13 July 2017
27 July 2017
15 November 2018
31 January 2019
28 February 2019
22 June 2017
WO 2020043750 A1
05 March 2020
NONE
WO 2019040664 A1
28 February 2019
AU 2018320870 A1
CA 3072610 A1
US 2019062724 A1
US 2019169595 A1
US 2019207890 A1
WO 2019040664 A1
27 February 2020
28 February 2019
28 February 2019
06 June 2019
04 July 2019
28 February 2019
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
22 April 2020
Date of mailing of the international search report:
04 May 2020
Authorized officer:
Bucka, Alexander
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