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1. WO2020163138 - ÉMULSIONS DE CANNABINOÏDES, BOISSONS ET ALIMENTS

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

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What is claimed is:

1. A method, comprising:

freezing a portion of a cannabis plant to produce frozen cannabis, wherein the cannabis plant comprises at least one cannabinoid;

submerging the frozen cannabis in at least 95% ethanol to produce a mixture;

storing the mixture for a duration sufficient to convert the ethanol into an ethanol-cannabinoid solution;

removing the ethanol-cannabinoid solution from the mixture;

concentrating the ethanol-cannabinoid solution using an evaporator, to produce a concentrated ethanol-cannabinoid solution;

distilling the concentrated ethanol-cannabinoid solution to an ethanol concentration of between about 5% and about 10%, to produce a cannabinoid concentrate;

heating the cannabinoid concentrate sufficient to decarboxylate the cannabinoid concentrate;

performing a distillation of the cannabinoid concentrate;

adding an oil comprising C14 triglycerides to the distilled cannabinoid concentrate; and processing the cannabinoid concentrate to form a cannabinoid emulsion.

2. The method of claim 1, wherein the cannabinoid emulsion is a cannabinoid nanoemulsion.

3. The method of claim 1, wherein the processing of cannabinoid concentrate into a cannabinoid emulsion is by microfluidizing and/or ultrasonicating

4. The method of claim 1, wherein the at least 95% ethanol is nondenatured absolute ethanol.

5. The method of claim 1, wherein the distillation is a molecular distillation.

6. The method of claim 1, wherein the oil is refined coconut oil.

7. The method of claim 1, further comprising:

reducing a temperature of the ethanol-cannabinoid solution to between about -40° C and about -80° C; and

removing a precipitate from the ethanol-cannabinoid solution prior to the concentrating of the ethanol-cannabinoid solution.

8. The method of claim 1, wherein the mixture is a first mixture, the method further comprising:

heating the ethanol-cannabinoid solution to a temperature of between about 50° C and about 80° C;

adding carbon to the heated ethanol-cannabinoid solution to produce a second mixture; agitating the second mixture; and

filtering the carbon from the second mixture.

9. The method of claim 1, further comprising:

separating cannabinoid compounds from the cannabinoid concentrate prior to forming the cannabinoid emulsion.

10. The method of claim 9, wherein the cannabinoid compounds are separated using chromatography .

11. The method of claim 10, wherein the chromatography is silica column chromatography.

12. The method of claim 1, further comprising:

homogenizing the cannabinoid concentrate after adding the oil and prior to forming the cannabinoid emulsion.

13. The method of claim 12, The method of claim 1, further comprising adding an additive to the cannabinoid concentrate prior to emulsion formation, wherein the additive is vitamin E, lecithin derived phospholipids, a preservative, water, or any combination thereof.

14. The method of claim 1, wherein the at least one cannabinol is a tetrahydrocannabinol or a tetrahydrocannabinolic acid.

15. The method of claim 1, wherein the at least one cannabinol is cannabidiolic acid or cannabidiol.

16. The method of claim 2, further comprising adding a cannabinoid microemulsion to the cannabinoid nanoemulsion to create a cannabinoid nanoemulsion/microemulsion.

17. A method, comprising:

de-alcoholizing beer to form a non-alcohol cereal beverage;

rectifying the non-alcohol cereal beverage by adding the cannabinoid emulsion of any one of claims 1-16, to the non-alcoholic cereal beverage; and

homogenizing the cannabinoid-infused cereal beverage.

18. The method of claim 17, further comprising carbonating the cannabinoid-infused cereal beverage to a desired carbonation level.

19. The method of claim 18, wherein the carbonating comprises introducing CO2 to the cannabinoid-infused cereal beverage using a carbonation stone.

20. The method of claim 17, further comprising analyzing the cannabinoid-infused cereal beverage to determine the quantity of a cannabinoid in the cannabinoid-infused cereal beverage.

21. The method of claim 17, further comprising analyzing the cannabinoid-infused cereal beverage to determine onset time, offset time, and/or potency of an effect of a cannabinoid in the beverage.

22. The method of claim 17, wherein the cannabinoid-infused cereal beverage comprises cannabinoid nanoemulsion/microemulsion.

23. The method of claim 17, further comprising packaging the carbonated cannabinoid-infused cereal beverage in a metallic can and adding an oil emulsion to the can.

24. The method of claim 23, wherein the metallic can is an aluminum can.

25. The method of claim 23, wherein the oil emulsion is a medium chain triglyceride (MCT) emulsion.

26. The method of claim 23, wherein the oil emulsion is added to the metallic can prior to the cannabinoid-infused cereal beverage.

27. The method of claim 23, wherein the addition of the oil emulsion results in the cannabinoid in the cannabinoid emulsion being available for ingestion in the beverage for a longer time than if the oil emulsion was not added.

28. The method of claim 27, wherein the cannabinoid available in the beverage loses less than 10% of its availability after at least one month of refrigeration.

29. The method of claim 27, wherein the cannabinoid available in the beverage loses less than 10% of its availability after at least one month at room temperature.

30. A method, comprising:

providing a beverage;

adjusting a pH of the beverage to a predetermined pH value;

infusing the pH-adjusted beverage with the cannabinoid emulsion of any one of claims 1- 16; and

carbonating the infused beverage to a desired CO2 volume, to produce a cannabinoid-infused carbonated beverage.

31. The method of claim 30, wherein the predetermined pH value is in a range of between about 4 and about 5.

32. The method of claim 30, wherein the predetermined pH value is about 4.6.

33. The method of claim 30, wherein the cannabinoid emulsion comprises a tetrahydrocannabinol and/or a cannabidiol.

34. The method of claim 30, further comprising adding an oil emulsion.

35. The method of claim 34, wherein the oil emulsion is a medium chain triglyceride (MCT) emulsion.

36. The method of claim 34, wherein the cannabinoid emulsion is available for ingestion in the beverage for a longer time than if the oil emulsion was not added.

37. The method of claim 36, wherein the measurable cannabinoid in the beverage decreases by less than 10% after at least one month of refrigeration.

38. The method of claim 36, wherein the measurable cannabinoid in the beverage decreases by less than 10% after at least one month at room temperature.

39. A cannabinoid emulsion made by the method of any one of claims 1-16.

40. The cannabinoid emulsion of claim 39, wherein the cannabinoid emulsion comprises a cannabinoid nanoemulsion.

41. The cannabinoid emulsion of claim 39, wherein the cannabinoid emulsion comprises a cannabinoid microemulsion.

42. The cannabinoid emulsion of claim 39, wherein the cannabinoid emulsion comprises a cannabinoid nanoemulsion/microemulsion.

43. The cannabinoid nanoemulsion of claim 40, having a mean droplet size of 75 nm or smaller.

44. The cannabinoid nanoemulsion of claim 40, having a mean droplet size of 50 nm or smaller.

45. The cannabinoid nanoemulsion of claim 40, having a mean droplet size of 15 nm or smaller.

46. The cannabinoid emulsion of claim 42, wherein the nanoemulsion component has a mean droplet size of 15-75 nm the and the microemulsion component has a mean droplet size of 100-400 nm.

47. The cannabinoid emulsion of claim 42, wherein the nanoemulsion component has a mean droplet size of 25 nm - 50 nm the and the microemulsion component has a mean droplet size of the of 150-300 nm.

48. The cannabinoid nanoemulsion of claim 40, wherein, when incorporated into a food or beverage, an effect of a cannabinoid therein is at least 50% faster than the same amount of the cannabinoid in the food or beverage that is not in the nanoemulsion.

49. The cannabinoid nanoemulsion of claim 40, wherein, when incorporated into a food or beverage, an effect of a cannabinoid therein is at least 80% faster than the same amount of the cannabinoid in the food or beverage that is not in the nanoemulsion.

50. The cannabinoid nanoemulsion of claim 40, wherein, when incorporated into a food or beverage, an effect of a cannabinoid therein is at least 80% faster than at least twice as much of the cannabinoid in the food or beverage that is not in the nanoemulsion.

51. The cannabinoid nanoemulsion of claim 40, wherein, when incorporated into a food or beverage, an effect of a cannabinoid therein is achieved with less than 20% of the quantity of the cannabinoid in the food or beverage that is not in the nanoemulsion.

52. The cannabinoid nanoemulsion of claim 48, wherein, when incorporated into a food or beverage, the effect lasts at least 50% shorter than the same amount of the cannabinoid in the beverage that is not in the nanoemulsion.

53. The cannabinoid emulsion of claim 42, wherein, when incorporated into a food or beverage,

an effect of a cannabinoid therein is at least 50% faster than the same amount of the cannabinoid in the food or beverage that is not in the emulsion, and

the effect lasts about as long as the same amount of the cannabinoid in the food or beverage that is not in the emulsion.

54. A beverage comprising a cannabinoid emulsion made by the method of any one of claims 1-16.

55. The beverage of claim 54, wherein the cannabinoid emulsion is a cannabinoid nanoemulsion.

56. The beverage of claim 55, wherein the cannabinoid nanoemulsion has a mean droplet size of 75 nm or smaller.

57. The beverage of claim 55, wherein the cannabinoid nanoemulsion has a mean droplet size of 50 nm or smaller.

58. The beverage of claim 55, wherein the cannabinoid nanoemulsion has a mean droplet size of 15 nm or smaller.

59. The beverage of claim 54, wherein the cannabinoid emulsion is a nanoemulsion/microemulsion.

60. The beverage of claim 59, wherein the nanoemulsion component has a mean droplet size of 15-75 nm the and the microemulsion component has a mean droplet size of 100-400 nm.

61. The beverage of claim 59, wherein the nanoemulsion component has a mean droplet size of 25 nm - 50 nm the and the microemulsion component has a mean droplet size of the of 150-300 nm.

62. The beverage of claim 55, wherein an effect of a cannabinoid therein is at least 50% faster than the same amount of cannabinoid not in the nanoemulsion in the beverage.

63. The beverage of claim 55, wherein an effect of a cannabinoid therein is at least 80% faster than the same amount of cannabinoid not in the nanoemulsion in the beverage.

64. The beverage of claim 55, wherein an effect of a cannabinoid therein is at least 80% faster than at least twice as much cannabinoid not in the nanoemulsion in the beverage.

65. The beverage of claim 55, wherein an effect of a cannabinoid therein is achieved with less than 20% of the quantity of the cannabinoid in the food or beverage that is not in the nanoemulsion.

66. The beverage of claim 62, wherein the effect lasts at least 50% shorter than the same amount of the cannabinoid in the beverage that is not in the nanoemulsion.

67. The beverage of claim 59, wherein

an effect of a cannabinoid therein is at least 50% faster than the same amount of the cannabinoid in the beverage that is not in the nanoemulsion/microemulsion, and

the effect lasts about as long as the same amount of the cannabinoid in the beverage that is not in the nanoemulsion/microemulsion.

68. The beverage of claim 63, comprising THC at a dosage of 5 mg or less per 6-12 oz serving.

69. The beverage of claim 54, wherein the beverage is coffee, tea, or a sparkling water.

70. The beverage of claim 54, wherein the beverage is beer.

71. The beverage of claim 70, wherein the beer is de- alcoholized.

72. The beverage of claim 71, wherein aroma that was volatilized when the beer was de-alcoholized is captured and infused back into the de- alcoholized beer.

73. The beverage of claim 71, wherein the beer is de- alcoholized by racking beer out of a fermentation vessel racking arm off trub and through a low temperature vacuum de-alcoholizer machine into a receiving tank.

74. The beverage of claim 54, wherein the beverage is carbonated.

75. The beverage of claim 54, packaged in a metallic can having a liner, wherein the beverage further comprises an oil emulsion, wherein the oil emulsion does not comprise a cannabinoid.

76. The beverage of claim 75, wherein the oil emulsion is a medium chain triglyceride (MCT) emulsion.

77. The beverage of claim 75, wherein the oil emulsion is added to the beverage prior to the cannabinoid emulsion.

78. The beverage of claim 75, wherein the cannabinoid emulsion is available for ingestion in the beverage for a longer time than if the oil emulsion was not added.

79. The beverage of claim 75, comprising THC at a dosage of 5 mg or less per can.

80. A method of packaging a liquid in a metallic container having a liner, the method comprising adding the liquid and an oil emulsion to the metallic container, wherein

the liquid comprises a hydrophobic agent in an emulsion; and

the hydrophobic agent is available for ingestion in the liquid for a longer time than if the oil emulsion was not added.

81. The method of claim 80, wherein the hydrophobic agent is a cannabinoid.

82. The method of claim 80, wherein the hydrophobic agent is in a microemulsion.

83. The method of claim 80, wherein the hydrophobic agent is in a nanoemulsion.

84. The method of claim 80, wherein the emulsion is the cannabinoid emulsion of claim 37.

85. The method of claim 84, wherein the cannabinoid emulsion comprises a cannabinoid nanoemulsion.

86. The method of claim 84, wherein the cannabinoid emulsion comprises a cannabinoid microemulsion.

87. The method of claim 84, wherein the cannabinoid emulsion comprises a nanoemulsion/microemulsion.

88. The method of claim 80, wherein the oil is a triglyceride.

89. The method of claim 88, wherein the triglyceride is medium chain triglyceride (MCT).

90. The method of claim 80, wherein the metallic container is an aluminum can.

91. The method of claim 80, wherein the liner is a BPA based liner.

92. The method of claim 80, wherein the beverage is coffee, tea or a sparkling water.

93. The method of claim 80, wherein the beverage is beer.

94. The method of claim 93, wherein the beer is de-alcoholized.

95. The method of claim 80, wherein the beverage is carbonated.

96. A beverage packaged by the method of claim 80.

97. The beverage of claim 96, wherein the beverage is coffee, tea or a sparkling water.

98. The beverage of claim 96, wherein the beverage is beer.

99. The beverage of claim 98, wherein the beer is de- alcoholized.

100. The beverage of claim 96, wherein the beverage is carbonated.

101. A solid food comprising a cannabinoid emulsion.

102. The solid food of claim 101, wherein the cannabinoid emulsion is the emulsion of claim 32.

103. The solid food of claim 101, wherein the cannabinoid emulsion further comprises maltodextrin.

104. The solid food of claim 101, wherein the cannabinoid emulsion comprises a cannabinoid nanoemulsion.

105. The solid food of claim 101, wherein the cannabinoid emulsion comprises a cannabinoid microemulsion.

106. The solid food of claim 101, wherein the cannabinoid emulsion comprises a cannabinoid nanoemulsion/microemulsion.

107. The solid food of claim 101, which is a gummy.

108. The solid food of claim 104, wherein an effect of a cannabinoid therein is at least 50% faster than the same amount of the cannabinoid in the food that is not in the nanoemulsion.

109. The solid food of claim 104, wherein an effect of a cannabinoid therein is at least 80% faster than the same amount of the cannabinoid in the food that is not in the nanoemulsion.

110. The solid food of claim 104, wherein an effect of a cannabinoid therein is at least 80% faster than the at least twice as much of the cannabinoid in the food that is not in the nanoemulsion.

111. The solid food of claim 104, wherein the effect lasts at least 50% shorter than the same amount of the cannabinoid in the food that is not in the nanoemulsion.

112. The solid food of claim 106, wherein the effect lasts about as long as the same amount of the cannabinoid in the food or beverage that is not in the nanoemulsion.

113. A method of producing a food or beverage with a cannabinoid that has a longer duration cannabinoid effect than the cannabinoid when in a single size nanoemulsion or microemulsion, the method comprising

combining a nanoemulsion with a microemulsion of the cannabinoid and produce the food or beverage with that combined nanoemulsion/microemulsion.

114. The method of claim 113, wherein the food or beverage is a beverage.

115. The method of claim 114, wherein the beverage is the beverage of claim 52.

116. The method of claim 113, wherein the food or beverage is a solid food.

117. The method of claim 116, wherein the solid food is the solid food of claim 80.

118. The method of claim 113, wherein the nanoemulsion component has a mean droplet size of 15-75 nm the and the microemulsion component has a mean droplet size of 100-400 nm.

119. The method of claim 113, wherein the nanoemulsion component has a mean droplet size of 25 nm - 50 nm the and the microemulsion component has a mean droplet size of the of 150-300 nm.