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International application No. Applicant's or agent's file reference
PCT/CN2020/117487 PF200643PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
24 September 2020 26 September 2019
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
This international search report has not been established in respect of certain claims under Article 17(2)(a) for the following reasons:
Claims Nos.: 21-22
because they relate to subject matter not required to be searched by this Authority, namely:
[1] Claims 21-22 are directed to the method for treating diseases, but the report is based on the use of the compound for the preparation of medicaments for treating the corresponding diseases.
Claims Nos.:
because they relate to parts of the international application that do not comply with the prescribed requirements to such an extent that no meaningful international search can be carried out, specifically:
Claims Nos.:
because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a).
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.

 Provided aza-quinoline compounds of Formula (I) ,pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2) , Polycomb Repressive Complex 2 (PRC2) , or a combination thereof.

6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
CNPAT,EPODOC,WPI,CNKI,STN: NOVARTIS AG,LI Ling,DAI Xuan,DORE Michael,GU Xiang-Ju Justin,LIU Kevin Kun Chin,MAK Sing Yeung Frankie,MI Yuan,OYANG Counde,PAPILLON Julien,QI Wei (Vicky),YAN Xiaoxia,YU Zhengtian,ZHANG Ji Yue (Jeff),ZHAO Kehao,quinoline,Polycomb Repressive Complex,PRC2,Enhancer of Zeste Homolog,EZH,structure search


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2016103155 A1 (NOVARTIS AG) 30 June 2016 (2016-06-30)
claims 1-20
WO 2017221100 A1 (NOVARTIS AG) 28 December 2017 (2017-12-28)
claims 1-16
WO 2017221092 A1 (NOVARTIS AG) 28 December 2017 (2017-12-28)
claims 1-20
WO 2017002064 A1 (GLAXOSMITHKLINE INTELLECTUAL PROPERTY NO.2 LTD) 05 January 2017 (2017-01-05)
claims 1-20
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2016103155 A1
30 June 2016
LT 3237418 T
TN 2017000204 A1
UY 36462 A
EP 3237418 B1
DK 3237418 T3
US 2019142837 A1
SI 3237418 T1
UA 120945 C2
US 2016176882 A1
HU E043060 T2
CR 20170285 A
PH 12017501016 A1
ES 2722048 T3
CN 107108637 B
JP 6736559 B2
EP 3237418 A1
CN 107108637 A
EA 201791420 A1
KR 20170095882 A
US 9580437 B2
IL 252135 D0
US 2017348312 A1
EA 032416 B1
TW 201629065 A
AU 2015370524 A1
PT 3237418 T
SG 11201703880V A
CL 2017001572 A1
BR 112017010354 A2
US 10220036 B2
EC SP17047153 A
SV 2017005472 A
RS 58679 B1
PL 3237418 T3
CA 2969090 A1
PE 20171307 A1
HR P20190805 T1
DO P2017000149 A
MX 2017008529 A
TW I694076 B
JP 2018500342 A
GT 201700146 A
AU 2015370524 B2
PH 12017501016 B1
10 May 2019
19 October 2018
29 July 2016
30 January 2019
13 May 2019
16 May 2019
28 June 2019
10 March 2020
23 June 2016
29 July 2019
21 August 2017
11 December 2017
07 August 2019
29 October 2019
05 August 2020
01 November 2017
29 August 2017
31 October 2017
23 August 2017
28 February 2017
31 July 2017
07 December 2017
31 May 2019
16 August 2016
01 June 2017
23 May 2019
28 July 2017
12 January 2018
26 December 2017
05 March 2019
28 February 2019
12 June 2018
28 June 2019
31 July 2019
30 June 2016
05 September 2017
28 June 2019
15 July 2017
25 October 2017
21 May 2020
11 January 2018
12 June 2019
01 November 2018
11 December 2017
WO 2017221100 A1
28 December 2017
CN 109790166 A
EP 3472166 A1
US 2019233426 A1
JP 2019524872 A
US 10676479 B2
21 May 2019
24 April 2019
01 August 2019
05 September 2019
09 June 2020
WO 2017221092 A1
28 December 2017
EP 3472161 B1
JP 2019522049 A
CN 109906224 A
US 10689378 B2
EP 3472161 A1
US 2019202828 A1
25 March 2020
08 August 2019
18 June 2019
23 June 2020
24 April 2019
04 July 2019
WO 2017002064 A1
05 January 2017
AU 2016286537 B2
EP 3317271 B1
JP 2018522874 A
UY 36758 A
BR 112017028616 A2
TW 201708210 A
KR 20180022834 A
AU 2016286537 A1
RU 2018103174 A3
EP 3317271 A1
US 2018162845 A1
RU 2018103174 A
CA 2990474 A1
CN 107849032 A
17 January 2019
13 May 2020
16 August 2018
30 December 2016
04 September 2018
01 March 2017
06 March 2018
18 January 2018
21 October 2019
09 May 2018
14 June 2018
01 August 2019
05 January 2017
27 March 2018
Name and mailing address of the ISA/:
National Intellectual Property Administration, PRC
6, Xitucheng Rd., Jimen Bridge, Haidian District, Beijing 100088
Facsimile No. (86-10)62019451
Date of the actual completion of the international search:
02 December 2020
Date of mailing of the international search report:
21 December 2020
Authorized officer:
Telephone No. 86-(10)-53962168
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