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1. WO2020162749 - PEPTIDE ANTIMICROBIEN POUR L'ONYCHOMYCOSE

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Claims

1 . Antimicrobial peptide for use in a method of preventing or treating onychomycosis, wherein the antimicrobial peptide comprises the amino acid sequence RRRRSVQWCA or ACWQVSRRRR or GRRRRSVQWCA or ACWQVSRRRRG, or a functional mutant thereof.

2. Composition comprising an antimicrobial peptide and a pharmaceutically acceptable diluent or excipient, for use in a method of preventing or treating onychomycosis, wherein the antimicrobial peptide comprises the amino acid sequence RRRRSVQWCA or ACWQVSRRRR or GRRRRSVQWCA or ACWQVSRRRRG, or a functional mutant thereof.

3. Composition for use according to claim 2, wherein the antimicrobial peptide is present in a concentration of between 1 mg/I and 500 mg/I, preferably between 2 mg/I and 250 mg/I, more preferably between 3 mg/I and 150 mg/I, most preferably between 3,3 mg/I and 100 mg/I, such as 33 mg/I or 50 mg/I.

4. Composition for use according to claim 2 or 3, wherein the antimicrobial peptide is present in a concentration between 1 mg/I and 10 mg/I, more preferably between 2 mg/I and 5 mg/I, most preferably in a concentration of about 3 mg/I or about 3,3 mg/I.

5. Composition for use according to claim 2 or 3, wherein the antimicrobial peptide is present in a concentration between 10 mg/I and 100 mg/I, more preferably between 20 mg/I and 50 mg/I, most preferably in a concentration of about 30 mg/I or about 33 mg/I.

6. Antimicrobial peptide for use according to claim 1 or composition for use according to any one of claims 2 - 5, wherein the peptide or composition is administered at least once weakly for at least 3 months.

7. Antimicrobial peptide for use or composition for use according to claim 6, wherein the peptide or composition is administered at least once every three days.

8. Antimicrobial peptide for use according to claim 1 or composition for use according to any one of claims 2 - 5, wherein the peptide or composition is administered at least once every three days, more preferably at least once every two days for at least 2 weeks.

9. Antimicrobial peptide for use or composition for use according to claim 8, wherein the peptide or composition is administered at least daily for at least two weeks, more preferably for at least 1 month, more preferably for at least 2 months, more preferably for at least 4 months, most preferably for at least 6 months, such as 6 months to 12 months.

10. Antimicrobial peptide for use according to any one of claims 1 or 6 - 9 or composition for use according to any one of claims 2 - 9, wherein the antimicrobial peptide or the composition is administered at least twice a day.

1 1 . Antimicrobial peptide for use according to any one of claims 1 or 6 - 10 or composition for use according to any one of claims 2 - 10, wherein the peptide or composition is applied to the eponychium and/or to the proximal nail fold.

12. Antimicrobial peptide for use according to any one of claims 1 or 6 - 1 1 or composition for use according to any one of claims 2 - 1 1 , wherein the peptide or composition is applied to the lateral nail folds and/or to the lateral nail grooves and/or to the nail plate.

13. Antimicrobial peptide for use according to any one of claims 1 or 6 - 12 or composition for use according to any one of claims 2 - 12, wherein the peptide or composition is applied to the hyponychium and/or to the proximal part of the nailbed.

14. Antimicrobial peptide for use according to any one of claims 1 or 6 - 13 or composition for use according to any one of claims 2 - 13, wherein the onychomycosis involves an infection with at least one of species of Fusarium, Microsporum, Malassezia, Epidermophyton, Trichophyton, and/or Candida albicans and/or at least one of other fungal species and/or combinations thereof.

15. Antimicrobial peptide comprising the sequence RRRRSVQWCA or ACWQVSRRRR or GRRRRSVQWCA or ACWQVSRRRRG, or a functional mutant thereof, for use in a method for the treatment of a patient suffering from onychomycosis, the method comprising or consisting of the step of administering a therapeutically effective amount of the antimicrobial peptide to the cuticle of a nail affected by the onychomycosis, of said patient.

16. Antimicrobial peptide for use according to claim 15, wherein the antimicrobial peptide is administered at least daily as an aqueous solution comprising between 1 mg/I and 100 mg/I of the antimicrobial peptide, for at least two weeks, such as for between two weeks and three years.

17. Antimicrobial peptide for use according to any one of claims 1 or 6 - 16 or composition for use according to any one of claims 2 - 14, wherein the antimicrobial peptide has a modified C- terminus and/or has a modified N-terminus, preferably a C-terminus that is modified by amidation and/or an N-terminus that is modified by acetylation.