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1. MXPA/a/2004/001868 - USE OF ANNELLATED PYRROLE COMPOUNDS IN THE TREATMENT OF ARTICULAR CARTILAGE OR SUBCHONDRAL BONE DEGENERATION

Office
Mexique
Numéro de la demande PA/a/2004/001868
Date de la demande 27.02.2004
Numéro de publication PA/a/2004/001868
Date de publication 02.12.2005
Type de publication A
CIB
A61K 31/40
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
33Composés hétérocycliques
395ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
40ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
Déposants MERCKLE GMBH
ASCENTIA PHARMA INC.
Inventeurs JEAN-PIERRE PELLETIER
JOHANNE MARTEL-PELLETIER
Mandataires NORA SILVIA CARMONA ROJAS.*
Données relatives à la priorité 2356099 30.08.2001 CA
60/315,773 30.08.2001 US
Titre
(EN) USE OF ANNELLATED PYRROLE COMPOUNDS IN THE TREATMENT OF ARTICULAR CARTILAGE OR SUBCHONDRAL BONE DEGENERATION
(ES) USO DE COMPUESTOS DE PIRROL ANILLADOS EN EL TRATAMIENTO DE LA DEGENERACIÓN DEL HUESO SUB-CONDRIAL O CARTÍLAGO ARTICULAR
Abrégé
(EN)
Treating or preventing degeneration or destruction of articular cartilage and/or subchondral bone in the affected joint of a mammal is accomplished by administering a compound of formula (I), wherein the variables have the meanings given in the present description. A preferred compound of formula (I) is formula (II). This treatment ameliorates, diminishes, actively treats, reverses or prevents any injury, damage or loss of articular cartilage or subchondral bone subsequent to sa id early stage of said degeneration.

(ES)
El tratamiento o la prevención de la degeneración o destrucción del cartílago articular y/o el hueso subcondrial en la articulación afectada de un mamífero que se realiza mediante la administración de un compuesto de la fórmula (I), en donde las variables tienen los significados proporcionados en la presente descripción. Un compuesto preferido de la fórmula (I) es la fórmula (II). Este tratamiento mejora, disminuye, cambia o previene activamente cualquier lesión, daño o pérdida, del cartílago articular o el hueso subcondrial después de la etapa temprana de la degeneración.

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