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1. WO2021038581 - SYNTHÈSE EN UNE ÉTAPE DE BENZO[B]THIOPHÈNES SUBSTITUÉS EN POSITION 2

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

The Claim:

1. A one step synthesis of 2-substituted benzo[b]thiophene of general formula


wherein the synthesis of 2-substituted benzo[b]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C- 30°C.

2. The synthesis as claimed in claim 1, wherein the starting material is one of

2-iodobenzaldehyde, 2-iodo-5-methylbenzaldehyde, 5-bromo-2- iodobenzaldehyde, 2-iodobenzophenone and 2 -iodochalcones .

3. The synthesis as claimed in claim 2, wherein the starting material is preferably 2-iodobenzaldehyde.

4. The synthesis as claimed in claim 1, wherein the starting material is one of phenacyl bromide, acetyl bromide, 2-bromocycloalkanone, 2-bromotetralone and 2-bromoindanone.

5. The synthesis as claimed in claim 4, wherein the starting material is preferably phenacyl bromide.

6. The synthesis as claimed in claim 1, wherein the catalyst is selected from one of Cu, Fe, Zn, Co, or Ni.

7. The synthesis as claimed in claim 6, wherein the catalyst is preferably copper acetate.

8. The synthesis as claimed in claim 1, wherein the sulphur source is preferably potassium ethyl xanthate.

9. The synthesis as claimed in claim 1, wherein the phase transfer catalyst is selected from one of tetrabutylammonium chloride, benzyltriethylammonium chloride, tetrabutylammonium bromide, tetraoctylammonium bromide or tetramethylammonium chloride.

10. The synthesis as claimed in claim 9, wherein the phase transfer catalyst is preferably tetrabutylammonium chloride.

11. The synthesis as claimed in claim 1, wherein the aqueous medium is water.

12. The synthesis as claimed in claim 1, wherein temperature is preferably in the range of 25°C- 30°C.

13. The synthesis as claimed in claim 1, wherein the ratio of reactants 2- iodobenzaldehyde and phenacyl bromide in the presence of sulphur source, phase transfer catalyst and the catalyst is 1: 1:3:1 :0.1 respectively.