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1. WO2016097183 - CELLULES TRANSGÉNIQUES DE L'ÉPITHÉLIUM PIGMENTAIRE RÉTINIEN (RPE) SUREXPRIMANT LE GÈNE OTX2 POUR LE TRAITEMENT DE LA DÉGÉNÉRESCENCE RÉTINIENNE


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2015/080288 B1938PC00
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
17 December 2015 18 December 2014
Applicant
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
TRANSGENIC RPE CELLS OVEREXPRESSING OTX2 FOR THE TREATMENT OF RETINAL DEGENERATION

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 35/12 (2006.01)i; C12N 5/10 (2006.01)i; C12N 15/86 (2006.01)i; C12N 7/00 (2006.01)i; C12N 15/864 (2006.01)i; A61K 48/00 (2006.01)i; C12N 5/079 (2010.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C12N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
EP 1591127 A1 (JAPAN SCIENCE & TECH AGENCY [JP]; OSAKA BIOSCIENCE INST [JP] JAPAN SCI) 02 November 2005 (2005-11-02)
1-8,11-15
paragraphs [0029], [0046] - [0052], [0054]; claims 3-5,7-9
(2)
X
SOON WON CHOI ET AL, "miR-410 Inhibition Induces RPE Differentiation of Amniotic Epithelial Stem Cells via Overexpression of OTX2 and RPE65", STEM CELL REVIEWS AND REPORTS,29 October 2014 (2014-10-29),
XP055191764
1-6,11-15
the whole document
(3)
A
WO 2013074681 A1 (ADVANCED CELL TECH INC [US]) 23 May 2013 (2013-05-23)
1-15
claims 1,2,7-9,27,28,31-33,54,55,74,124,141-153,167,204
(4)
A
WO 2011063005 A2 (ADVANCED CELL TECH INC [US]; MALCUIT CHRISTOPHER [US]; LEMIEUX LINDA [) 26 May 2011 (2011-05-26)
1,6,7,10-15
cited in the application
paragraphs [0021], [0090] - [0096], [0153] - [0155]; claims 1-4, 18-19,30-33,47-48,56-71; examples 23-27; table 5
(5)
A
WO 2009132156 A1 (REGENERATIVE RES FOUNDATION [US]; TEMPLE SALLY [US]; SALERO-COCA ENRIQ) 29 October 2009 (2009-10-29)
1,6,11-15
paragraphs [0019], [0022], [0038]; claims 1-3,14-15,26-33
(6)
A
Mika Reinisalo ET AL, "Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site", United States 10 January 2012 (2012-01-10), page 38-54,
Retrieved from the Internet:
URL:http://www.ncbi.nlm.nih.gov/pubmed/22259223
XP055191927
[retrieved on  2015-05-27]
1-7
the whole document
(7)
A
J. R. MARTINEZ-MORALES ET AL, "OTX2 Activates the Molecular Network Underlying Retina Pigment Epithelium Differentiation", JOURNAL OF BIOLOGICAL CHEMISTRY,Vol. 278, No. 24, 27 March 2003 (2003-03-27), page 21721-21731,
XP055191939
1
page 21728, left-hand column, paragraph discussion - page 21730, right-hand column, paragraph 2
(8)
A
JEROME E. ROGER ET AL, "OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness", JOURNAL OF CLINICAL INVESTIGATION,Vol. 124, No. 2, 02 January 2014 (2014-01-02), page 631-643,
XP055191950
1-15
page 640, right-hand column, paragraph 2
(9)
A
CHIBA C ET AL, "Intraocular implantation of DNA-transfected retinal pigment epithelium cells: a new approach for analyzing molecular functions in the newt retinal regeneration", NEUROSCIENCE LETTERS, LIMERICK, IE,Vol. 368, No. 2, 23 September 2004 (2004-09-23), page 171-175,
XP004559765
7,8,10,12
the whole document
(10)
A
BERTOLOTTI EVELINA ET AL, "Stem cells as source for retinal pigment epithelium transplantation", PROGRESS IN RETINAL AND EYE RESEARCH, OXFORD, GB,Vol. 42, 13 June 2014 (2014-06-13), page 130-144,
XP029046414
1
the whole document
(11)
A
M. HOUSSET ET AL, "Loss of Otx2 in the Adult Retina Disrupts Retinal Pigment Epithelium Function, Causing Photoreceptor Degeneration", JOURNAL OF NEUROSCIENCE,Vol. 33, No. 24, 12 June 2013 (2013-06-12), page 9890-9904,
XP055191918
1
the whole document
(12)
X,P
KR 20150042598 A (X) 21 April 2015 (2015-04-21)
1-8,10-15
claims 4-7, 10-12
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
EP 1591127 A1
02 November 2005
CA 2514971 A1
CN 1747744 A
EP 1591127 A1
ES 2428892 T3
JP 4676332 B2
JP 2011042656 A
KR 20050105448 A
KR 20080098451 A
KR 20090054480 A
KR 20090096561 A
US 2006122111 A1
US 2010273265 A1
US 2011097726 A1
WO 2004069268 A1
19 August 2004
15 March 2006
02 November 2005
12 November 2013
27 April 2011
03 March 2011
04 November 2005
07 November 2008
29 May 2009
10 September 2009
08 June 2006
28 October 2010
28 April 2011
19 August 2004
WO 2013074681 A1
23 May 2013
AU 2012340020 A1
CA 2855941 A1
CN 104080464 A
EP 2780022 A1
GB 2496969 A
HK 1202456 A1
JP 2014533289 A
KR 20140096368 A
TW 201333200 A
US 2013195806 A1
US 2015366915 A1
WO 2013074681 A1
03 July 2014
23 May 2013
01 October 2014
24 September 2014
29 May 2013
02 October 2015
11 December 2014
05 August 2014
16 August 2013
01 August 2013
24 December 2015
23 May 2013
WO 2011063005 A2
26 May 2011
CA 2781149 A1
EP 2501802 A2
KR 20120102709 A
US 2013149284 A1
WO 2011063005 A2
26 May 2011
26 September 2012
18 September 2012
13 June 2013
26 May 2011
WO 2009132156 A1
29 October 2009
CA 2721952 A1
EP 2279247 A1
US 2009274667 A1
US 2013330302 A1
WO 2009132156 A1
29 October 2009
02 February 2011
05 November 2009
12 December 2013
29 October 2009
KR 20150042598 A
21 April 2015
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
29 January 2016
Date of mailing of the international search report:
09 February 2016
Authorized officer:
Chambonnet, F
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