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1. WO2006007065 - PROCEDE ET APPAREIL D'IMAGERIE CHIMIQUE SUR FOND SOMBRE

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

What is claimed is:
1. A method for obtaining a spatially accurate wavelength-resolved image of a sample, the method comprising the steps of:

providing a sample;

illuminating the sample with a plurality of photons to thereby produce photons scattered by the sample; and

collecting the scattered photons through an optical device to thereby obtain a spatially accurate wavelength-resolved image of the sample,

wherein the illuminating photons do not pass through the optical device.

2. The method of Claim 1 wherein the scattered photons include photons emitted by the sample.

3. The method of Claim 1 wherein the wavelength-resolved image includes a Raman image.

4. The method of Claim 1 wherein the wavelength-resolved image includes a luminescence emission image.

5. The method of Claim 1 wherein the step of collecting the scattered photons includes collecting scattered photons having a wavelength in a predetermined wavelength band.

6. The method of Claim 5 wherein the step of collecting the scattered photons includes obtaining plural sets of scattered photons,

wherein each set of scattered photons contains photons in a predetermined wavelength band different from the predetermined wavelength band of the other sets of scattered photons, and

wherein a spatially accurate wavelength-resolved image of the sample is obtained from each set of scattered photons.

7. The method of Claim 1 wherein the step of collecting the scattered photons occurs during a predetermined time interval.

8. The method of Claim 6 wherein during said time interval the sample undergoes a change selected from the group of changes consisting of: spatial
displacement, chemical interaction, chemical state, phase, growth, shrinkage, chemical decomposition, chemical metabolization, and physical strain.

9. The method of Claim 1 wherein the step of illuminating the sample includes illuminating the sample with photons that travel at an angle that is oblique to a plane along which the sample is substantially oriented.

10. The method of Claim 1 wherein the wavelength of the scattered photons is different than the wavelength of the illuminating photons.

11. The method of Claim 1 wherein the step of illuminating the sample includes illuminating a side of the sample opposite the optical device.

12. The method of Claim 1 wherein the step of illuminating the sample includes photons from an evanescence light source.

13. The method of Claim 1 wherein the step of collecting scattered photons includes collecting scattered polarized photons.

14. The method of Claim 1 wherein the step of collecting scattered photons includes collecting scattered un-polarized photons.

15. The method of Claim 1 further comprising the step of filtering the collected photons though an optical filter.

16. The method of Claim 1 further comprising the step of spectrally separating the collected photons.

17. A system for obtaining a spatially accurate wavelength-resolved image of a sample, comprising:

a sample;

a photon emission source for illuminating the sample with a plurality of photons to thereby produce photons scattered by the sample;

an optical lens for collecting the scattered photons;

a filter for receiving the collected scattered photons and providing therefrom filtered photons; and

a charged couple device for receiving the filtered photons and obtaining therefrom a spatially accurate wavelength-resolved image of the sample,

wherein the illuminating photons do not pass through the optical lens.

18. The method of Claim 17 wherein the scattered photons include photons emitted by the sample.

19. The method of Claim 17 wherein the wavelength-resolved image includes a Raman image.

20. The method of Claim 17 wherein the wavelength-resolved image includes a luminescence emission image.

21. The method of Claim 17 wherein the step of collecting the scattered photons includes collecting scattered photons having a wavelength in a predetermined wavelength band.

22. The method of Claim 21 wherein the step of collecting the scattered photons includes obtaining plural sets of scattered photons,

wherein each set of scattered photons contains photons in a predetermined wavelength band different from the predetermined wavelength band of the other sets of scattered photons, and

wherein a spatially accurate wavelength-resolved image of the sample is obtained from each set of scattered photons.

23. The method of Claim 17 wherein the step of collecting the scattered photons occurs during a predetermined time interval.

24. The method of Claim 22 wherein during said time interval the sample undergoes a change selected from the group of changes consisting of: spatial
displacement, chemical interaction, chemical state, phase, growth, shrinkage, chemical decomposition, chemical metabolization, and physical strain.

25. The method of Claim 17 wherein the step of illuminating the sample includes illuminating the sample with photons that travel at an angle that is oblique to a plane along which the sample is substantially oriented.

26. The method of Claim 17 wherein the wavelength of the scattered photons is different than the wavelength of the illuminating photons.

' 27. The method of Claim 17 wherein the step of illuminating the sample
includes a side of the sample opposite the optical device.

28. The method of Claim 17 wherein the step of illuminating the sample
includes photons from an evanescence light source.

29. The method of Claim 17 wherein the step of collecting scattered photons includes collecting scattered polarized photons.

30. The method of Claim 17 wherein the step of collecting scattered photons includes collecting scattered un-polarized photons.

31. The method of Claim 17 further comprising the step of filtering the
collected photons though an optical filter.

32. The method of Claim 17 further comprising the step of spectrally
separating the collected photons.

33. The system of Claim 17 wherein the tunable filter includes one or more photonic crystals, a mirror, a solid state optical device and a micromachined tunable filter.

34. The system of Claim 17 wherein the filter is a tunable filter.

35. The system of Claim 34 wherein the tunable filter is an optical filter.

36. The system of Claim 17 further comprising a notch filter interposed between the optical lens and the filter.

37. The system of Claim 17 wherein the photon illumination source is positioned at an angle with respect to an axis formed by the sample and the filer.

38. The device of Claim 17 wherein the one or more wavelength-resolved images of a sample defines a Raman image.

39. An apparatus for forming an image of a sample comprising:

a photon transmitter for transmitting a plurality of illuminating photons to a sample;

said sample for producing scattered photons from said plurality of illuminating photons;

a lens for collecting the scattered photons and forming the image of the sample; and

a tunable filter for receiving the collected photons therefrom,

wherein the photon transmitter, the sample and the tunable filter are positioned relative to each other so that the angle between the illuminating photons and the scattered photons forms an oblique angle.

40. The apparatus of Claim 39 wherein the scattered photons include photons emitted by the sample.

41. The apparatus of Claim 39 further comprising an optical filter interposed between the tunable filter and the lens.

42. The apparatus of Claim 39 wherein the lens collects substantially none of the illuminated photons.

43. The apparatus of Claim 39 wherein the formed image is a Raman image.

44. The apparatus of Claim 39 wherein the tunable filter is a liquid crystal tunable filter.

45. The apparatus of Claim 39 further comprising a charged couple device.

46. The apparatus of Claim 39 wherein the formed image is a luminescence emission image.

47. A method for obtaining a spatially accurate wavelength-resolved image of a sample, the method comprising the steps of:

providing a sample;

illuminating the sample with a plurality of photons to thereby produce photons emitted by the sample; and

collecting the emitted photons through an optical device to thereby obtain a spatially accurate wavelength-resolved image of the sample,

wherein the illuminating photons do not pass through the optical device.

48. The method of Claim 47 wherein the wavelength-resolved image includes a Raman image.

49. The method of Claim 47 wherein the wavelength-resolved image includes a luminescence emission image.

50. The method of Claim 47 wherein the step of collecting the emitted photons includes collecting emitted photons having a wavelength in a predetermined wavelength band.

51. The method of Claim 50 wherein the step of collecting the emitted photons includes obtaining plural sets of emitted photons,

wherein each set of emitted photons contains photons in a predetermined wavelength band different from the predetermined wavelength band of the other sets of emitted photons, and

wherein a spatially accurate wavelength-resolved image of the sample is obtained from each set of emitted photons.

52. The method of Claim 47 wherein the step of collecting the emitted photons occurs during a predetermined time interval.

53. The method of Claim 51 wherein during said time interval the sample undergoes a change selected from the group of changes consisting of: spatial
displacement, chemical interaction, chemical state, phase, growth, shrinkage, chemical decomposition, chemical metabolization, and physical strain.

54. The method of Claim 47 wherein the step of illuminating the sample " includes illuminating the sample with photons that travel at an angle that is oblique to a plane along which the sample is substantially oriented.

55. The method of Claim 47 wherein the wavelength of the emitted photons is different than the wavelength of the illuminating photons.

56. • The method of Claim 47 wherein the step of illuminating the sample includes illuminating a side of the sample opposite the optical device.

57. The method of Claim 47 wherein the step of illuminating the sample includes photons from an evanescence light source.

58. The method of Claim 47 wherein the step of collecting emitted photons includes collecting emitted polarized photons.

59. The method of Claim 47 wherein the step of collecting emitted photons includes collecting emitted un-polarized photons.

60. The method of Claim 47 further comprising the step of filtering the collected photons though an optical filter.

61. The method of Claim 47 further comprising the step of spectrally separating the collected photons.

62. A system for obtaining a spatially accurate wavelength-resolved image of a sample, comprising:

a sample;

a photon emission source for illuminating the sample with a plurality of photons to thereby produce photons emitted by the sample;

an optical lens for collecting the emitted photons;

a filter for receiving the collected emitted photons and providing therefrom filtered photons; and

a charged couple device for receiving the filtered photons and obtaining therefrom a spatially accurate wavelength-resolved image of the sample,

wherein the illuminating photons do not pass through the optical lens.

63. The method of Claim 62 wherein the wavelength-resolved image includes a Raman image.

64. The method of Claim 62 wherein the wavelength-resolved image includes a luminescence emission image.

65. The method of Claim 62 wherein the'step of collecting the emitted photons includes collecting emitted photons having a wavelength in a predetermined wavelength band.

66. The method of Claim 65 wherein the step of collecting the emitted photons includes obtaining plural sets of emitted photons,

wherein each set of emitted photons contains photons in a predetermined wavelength band different from the predetermined wavelength band of the other sets of emitted photons, and

wherein a spatially accurate wavelength-resolved image of the sample is obtained from each set of emitted photons.

67. The method of Claim 62 wherein the step of collecting the emitted photons occurs during a predetermined time interval.

68. The method of Claim 66 wherein during said time interval the sample undergoes a change selected from the group of changes consisting of: spatial
displacement, chemical interaction, chemical state, phase, growth, shrinkage, chemical decomposition, chemical metabolization, and physical strain.

69. The method of Claim 62 wherein the step of illuminating the sample includes illuminating the sample with photons that travel at an angle that is oblique to a plane along which the sample is substantially oriented.

70. The method of Claim 62 wherein the wavelength of the emitted photons is different than the wavelength of the illuminating photons.

71. The method of Claim 62 wherein the step of illuminating the sample includes a side of the sample opposite the optical device.

72. The method of Claim 62 wherein the step of illuminating the sample includes photons from an evanescence light source.

73. The method of Claim 62 wherein the step of collecting emitted photons includes collecting emitted polarized photons.

74. The method of Claim 62 wherein the step of collecting emitted photons includes collecting emitted un-polarized photons.

75. The method of Claim 62 further comprising the step of filtering the collected photons though an optical filter.

76. The method of Claim 62 further comprising the step of spectrally separating the collected photons.

77. The system of Claim 62 wherein the tunable filter includes one or more photonic crystals, a mirror, a solid state optical device and a micromachined tunable filter.

78. The system of Claim 62 wherein the filter is a tunable filter.

79. The system of Claim 78 wherein the tunable filter is an optical filter.

80. The system of Claim 62 further comprising a notch filter interposed between the optical lens and the filter.

81. The system of Claim 62 wherein the photon illumination source is positioned at an angle with respect to an axis formed by the sample and the filer.

82. The device of Claim 62 wherein the one or more wavelength-resolved images of a sample defines a Raman image.

83. An apparatus for forming an image of a sample comprising:

a photon transmitter for transmitting a plurality of illuminating photons to a sample;

said sample for producing emitted photons from said plurality of illuminating photons;

a lens for collecting the emitted photons and forming the image of the sample; and

a tunable filter for receiving the collected photons therefrom,

wherein the photon transmitter, the sample and the tunable filter are positioned relative to each other so that the angle between the illuminating photons and the emitted photons forms an oblique angle.

84. The apparatus of Claim 83 further comprising an optical filter interposed between the tunable filter and the lens.

85. The apparatus of Claim 83 wherein the lens collects substantially none of the illuminated photons.

86. The apparatus of Claim 83 wherein the formed image is a Raman image.

87. The apparatus of Claim 83 wherein the tunable filter is a liquid crystal tunable filter.

88. The apparatus of Claim 83 further comprising a charged couple device.

89. The apparatus of Claim 83 wherein the formed image is a luminescence emission image.