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1. WO2007104562 - COMPOSITIONS EN POUDRE SECHE ET SYSTEMES DE VACCINATION DE VOLAILLE

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CLAIMS

1. A dry powder composition for poultry vaccination via inhalation comprising an effective amount of a poultry vaccine agent, and a supporting amount of carriers for said poultry vaccine agent, said carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to 4.0.

2. A dry powder composition for poultry vaccination according to claim 1 , wherein the vaccine agent is selected from the group consisting of viruses, bacteria, fungi, parasites, and parts thereof.

3. A dry powder composition for poultry vaccination according to claim 2, wherein the virus is selected from the group consisting of Paramyxoviridae, Newcastle Disease Virus, Pneumoviruses, Orthomyxoviridae, Influenza virus, Coronaviridae, Infectious Bronchitis virus, Turkey Coronavirus, Turkey Torovirus, Picornaviridae, Avian Encephalomyelitis virus, Duck Hepatitis virus, Turkey Hepatitis virus, Reoviridae, Rotavirus, Birnaviridae,

Infectious Bursal Disease Virus, Retroviridae, Avian Leukosis/Sarcoma virus, Astroviridae, Parvovihdae, Goose Parvovirus, Adenoviridae, Herpesviridae, Infectious Laryngotracheitis virus, Marek's Disease virus, Pox viridae, Hepadnaviridae, Duck Hepatitis virus, Turkey Hepatitis virus, Circoviridae, Papovaviridae, Goose Hemorrhagic Polyomavirus,

Caliciviridae, Togaviridae, Arteriviridae, Flaviviridae, Bunyaviridae, Rhabdoviridae, Filoviridae, Arenaviridae,

4. A dry powder composition for poultry vaccination according to any of claims 1 to 3, wherein the proportion of said carriers is from 90% by weight to 99.999 % by weight of said dry powder composition.

5. A dry powder composition for poultry vaccination according to any of claims 1 to 4, wherein said dry powder is in the form of particles having an average particle size from 10 to 30 μm.

6. A dry powder composition for poultry vaccination according to any of claims 1 to 4, wherein said dry powder is in the form of particles having an average particle size from 3 to 9 μm.

7. A dry powder composition for poultry vaccination according to any of claims 1 to 6, wherein said reducing sugar is selected from the group consisting of glucose, fructose, mannose, galactose, sorbose, xylose, ribose, lactose, maltose, cellobiose, and mixtures thereof.

8. A dry powder composition for poultry vaccination according to any of claims 1 to 6, wherein said non-reducing sugar is selected from the group consisting of trehalose, sucrose and mixtures thereof.

9. A dry powder composition for poultry vaccination according to any of claims 1 to 8, wherein said biocompatible polymer is selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, dextran, chemically modified dextran, aliphatic polyesters, polyacrylic acid, carrageenan, chitosan, cellulose derivatives, inulin, maltodextrin, polydextrose, polyethylene glycol, polyethylene oxide, polymethacrylates, starch, and mixtures thereof.

10. A dry powder composition for poultry vaccination according to any of claims 1 to 9, wherein the weight ratio of said biocompatible polymer to said reducing or non-reducing sugar in said combination of carriers is from 1/1 to 1/8.

11. A dry powder composition for poultry vaccination according to any of claims 1 to 10, wherein said carriers further comprise one or more proteins and/or polyols.

12. A dry powder composition for poultry vaccination according to any of claims 1 to 11 , wherein the water content of said dry powder composition is not above 4% by weight at the time of production.

13. A method of producing a dry powder vaccination composition, said method comprising spray-drying a liquid phase comprising a mixture of a vaccine agent, a liquid carrier and a supporting amount of solid carriers comprising a combination of a reducing or non-reducing sugar and a biocompatible polymer to provide said dry powder vaccination composition in the form of particles having an average particle size from 2 to 30 μm.

14. A method according to claim 13, wherein the vaccine agent is selected from the group consisting of viruses, bacteria, fungi, parasites, and parts thereof.

15.A method according to claim 14, wherein the virus is selected from the group consisting of Paramyxoviridae, Newcastle Disease Virus, Pneumoviruses, Orthomyxoviridae, Influenza virus, Coronaviridae, Infectious Bronchitis virus, Turkey Coronavirus, Turkey Torovirus,

Picornaviridae, Avian Encephalomyelitis virus, Duck Hepatitis virus, Turkey Hepatitis virus, Reoviridae, Rotavirus, Bimaviridae, Infectious Bursal Disease Virus, Retroviridae, Avian Leukosis/Sarcoma virus, Astroviridae, Parvoviridae, Goose Parvovirus, Adenoviridae, Herpesviridae, Infectious Laryngotracheitis virus, Marek's Disease virus, Pox viridae,

Hepadnaviridae, Duck Hepatitis virus, Turkey Hepatitis virus, Circoviridae, Papovaviridae, Goose Hemorrhagic Polyomavirus, Caliciviridae, Togaviridae, Arteriviridae, Flaviviridae, Bunyaviridae, Rhabdoviridae, Filoviridae, Arenaviridae,

16. A method according to any of claims 13 to 15, wherein spray-drying is effected at an inlet temperature ranging from 30°C to 1900C.

17. A method according to any of claims 13 to 16, wherein spray-drying is effected in a spray-drying equipment suitable for providing a dry powder composition having a particle size polydispersity from 1.1 to 4.0.

18. A system for performing vaccination in poultry via inhalation comprising :

- a chamber containing a dry powder vaccination composition comprising an effective amount of a poultry vaccine comprising a vaccine agent and a supporting amount of one or more carriers for said poultry vaccine, said dry powder composition being in the form of particles having an average particle size from 2 to 30 μm and a particle size polydispersity from 1.1 to

4.0, and
- means for nebulizing the dry powder vaccination composition over said poultry.

19. A system for performing vaccination in poultry according to claim 18, wherein the vaccine agent is selected from the group consisting of viruses, bacteria, fungi, parasites, and parts thereof.

20. A system for performing vaccination in poultry according to claim 19, wherein the virus is selected from the group consisting of Paramyxoviridae,

Newcastle Disease Virus, Pneumoviruses, Orthomyxoviridae, Influenza virus, Coronaviridae, Infectious Bronchitis virus, Turkey Coronavirus,

Turkey Torovirus, Picornaviridae, Avian Encephalomyelitis virus, Duck

Hepatitis virus, Turkey Hepatitis virus, Reoviridae, Rotavirus, Bimaviridae, Infectious Bursal Disease Virus, Retroviridae, Avian Leukosis/Sarcoma virus, Astroviridae, Parvoviridae, Goose Parvovirus, Adenoviridae,

Herpesviridae, Infectious Laryngotracheitis virus, Marek's Disease virus,

Pox viridae, Hepadnaviridae, Duck Hepatitis virus, Turkey Hepatitis virus,

Circoviridae, Papovaviridae, Goose Hemorrhagic Polyomavirus, Caliciviridae, Togaviridae, Arteriviridae, Flaviviridae, Bunyaviridae,

Rhabdoviridae, Filoviridae, Arenaviridae,

21. A system for performing vaccination in poultry according to any of claims 18 to 20, wherein the water content of said dry powder composition is not above 4% by weight.

22. A system for performing vaccination in poultry according to any of claims 18 to 21 , wherein said one or more carriers are selected from the group consisting of reducing sugars, non-reducing sugars, biocompatible polymers, proteins and polyols.

23. A system for performing vaccination in poultry according to any of claims 18 to 22, wherein said one or more carriers comprise a combination of a reducing or non-reducing sugar and a biocompatible polymer.

24. A system for performing vaccination in poultry according to claim 23, wherein the weight ratio of said biocompatible polymer to said reducing or non-reducing sugar in said combination is from 1/1 to 1/8.

25. A system for performing vaccination in poultry according to any of claims 18 to 24, wherein the proportion of said one or more carriers is from 90% by weight to 99.999 % by weight of said dry powder composition.