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1. WO2019115482 - FILTRE SANGUIN MOULÉ PAR INJECTION À RÉSISTANCE RÉDUITE

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[ EN ]

CLAIMS:

1. A device (10) for filtering red blood cells, the device comprising:

a main body (12) having at least one inlet (14) and at least one outlet (16); a filtering region (18) extending through the main body from the inlet to the outlet;

a filter (20) comprising pillars (22) disposed in the filtering region and grouped into islands (24), the pillars of each island having inter-pillar spacings (A) effective to trap red blood cells, the islands having inter-island spacings (B) that are larger than the inter-pillar spacings, the islands distributed in the filtering region to define tortuous flow paths (26) between the islands from the inlet to the outlet.

2. The device (10) of claim 1, wherein the inter-island spacings (B) are effective to not trap red blood cells in the tortuous paths (26).

3. The device (10) of either one of claims 1 and 2, wherein the inter-pillar spacings (A) are in a range between 10 pm and 30 pm inclusive.

4. The device (10) of any one of claims 1-3, wherein the inter-island spacings (B) are at least 100 pm.

5. The device (10) of any one of claims 1-4, wherein the islands (24) have a size are in a range between 100 pm and 150,000 pm inclusive.

6. The device (10) of any one of claims 1-5, further comprising:

a cell (32) comprising a plate (34) into which fluidic passages including the inlet (14), the filtering region (18), and the outlet (16) connecting with at least one reaction chamber region (38) are formed; and

a cover plate (26) covering the fluidic passages.

7. The device (10) of any one of claims 1-6, wherein the inter-island spacings (B) decrease along the tortuous flow paths (26) from the inlet (14) to the outlet (16).

8. The device (10) of any one of claims 1-7, wherein sizes of the islands (24) increase along the tortuous flow paths (26) from the inlet (14) to the outlet (16).

9. The device (10) of any one of claims 1-8, further comprising:

a red blood cell aggregating agent (28) disposed on at least one surface of the filtering region (18).

10. A blood processing device (30) comprising:

a cell (32) comprising a plate having fluidic passages defined in the plate of passage size effective to transport blood through the fluidic passages by capillary action; and a cover plate (36) disposed on the plate and sealing the fluidic passages;

wherein the fluidic passages include a red blood cell filtering region (18) having an inlet (14) and an outlet (16), the red blood cell filtering region comprising pillars (22) grouped into islands (24), the pillars of each island having inter-pillar spacings (A) effective to trap red blood cells, the islands having inter-island spacings that are larger than the inter-pillar spacings (B), the islands distributed in the red blood cell filtering region to define tortuous flow paths (26) between the islands from the inlet to the outlet.

11. The blood processing device (30) of claim 10, wherein the inter-island spacings (B) are effective to not trap red blood cells in the tortuous paths (26).

12. The blood processing device (30) of either one of claims 10 and 11, wherein the inter-pillar spacings (A) are in a range between 10 pm and 30 pm inclusive.

13. The blood processing device (30) of any one of claims 10-12, wherein the inter island spacings (B) are at least 100 pm.

14. The device (30) of any one of claims 10-13, wherein the islands (24) have a size are in a range between 100 pm and 150,000 pm inclusive.

15. The blood processing device (30) of any one of claims 10-14, wherein:

the fluidic passages further include at least one reaction chamber region (38), each reaction chamber region containing at least one blood assay reagent (40), the at least one reaction chamber region being in fluid communication with the outlet (16) of the filtering region (18).

16. The blood processing device (30) of any one of claims 10-15, wherein the inter island spacings (B) decrease along the tortuous flow paths (26) from the inlet (14) to the outlet

(16).

17. The blood processing device (30) of any one of claims 10-16, wherein sizes of the islands (24) increase along the tortuous flow paths (26) from the inlet (14) to the outlet (16).

18. The blood processing device (30) of any one of claims 10-17, further comprising: a red blood cell aggregating agent (28) disposed on at least one surface of the red blood cell filtering region (18).

19. A blood processing device manufacturing method (100) comprising:

injection molding a plate (34) having fluidic passages defined in the plate, wherein the fluidic passages include a red blood cell filtering region with pillars (22) grouped into islands (24) in the red blood cell filtering region, the pillars of each island having inter pillar spacings (A), the islands having inter-island spacings (B) that are larger than the inter pillar spacings; and

securing a cover plate (36) onto the plate to seal the fluidic passages and form a cell (32).

20. The blood processing device manufacturing method (100) of claim 19, further comprising:

after the injection molding operation and before the securing operation, disposing a red blood cell aggregating agent in the red blood cell filtering region such that the red blood cell aggregating agent is disposed in the red blood cell filtering region after the securing operation.