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1. WO2020163814 - COMPOSITIONS ET PROCÉDÉS POUR GÉNÉRER DES CELLULES CILIÉES PAR INHIBITION DE CIBLES ÉPIGÉNÉTIQUES


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2020/017354 FREQ-04601WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
07 February 2020 08 February 2019
Applicant
FREQUENCY THERAPEUTICS, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12N 5/0793 (2010.01)i; A61K 31/19 (2006.01)i; C12N 5/0797 (2010.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12N; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2017151907 A1 (FREQUENCY THERAPEUTICS INC) 08 September 2017 (2017-09-08)
1,2,4-9,12,13,19-27,37-46
Y
paragraph [0260] - paragraph [0265]; example 1
3,9-11,14-18,28-36
claims 1, 20
(2)
X
WO 2016037016 A1 (BRIGHAM & WOMENS HOSPITAL [US]; MASSACHUSETTS INST TECHNOLOGY [US]) 10 March 2016 (2016-03-10)
1,2,4-9,12,13,19-27,37-46
Y
paragraph [0203]
3,9-11,14-18,28-36
paragraph [0382] - paragraph [0388]
paragraph [0474] - paragraph [0478]
claims 1, 34-37; example 1
(3)
X
WILL J. MCLEAN ET AL, "Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells", CELL REPORTS,Vol. 18, No. 8, 01 February 2017 (2017-02-01), page 1917-1929,
XP055597888
1,2,4-8,20,21,43-46
Y
page 1918 - page 1921; figures 1-4
3,9-11,15-18,28-36
page 1926, right-hand column, paragraph 2 - page 1927, left-hand column, paragraph 8
(4)
Y
WO 2015168149 A2 (MASSACHUSETTS EYE & EAR INFIRM [US]) 05 November 2015 (2015-11-05)
3,9-11,14-18,28-36
page 9 - page 11
claims 1-3, 10; figure 15
(5)
A
Yingzi He ET AL, "Cellular & Molecular Medicine: Open access Redundant roles of HDACs in hair cell regeneration", 09 December 2015 (2015-12-09),
Retrieved from the Internet:
URL:http://cellular-molecular-medicine.imedpub.com/epigenetic-and-signaling-pathway-regulationin-hair-cell-regeneration.pdf
XP055292177
[retrieved on  2016-07-29]
1-46
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2017151907 A1
08 September 2017
AU 2017227844 A1
CA 3014659 A1
CN 109689052 A
EP 3423056 A1
JP 2019507802 A
US 2019093079 A1
WO 2017151907 A1
30 August 2018
08 September 2017
26 April 2019
09 January 2019
22 March 2019
28 March 2019
08 September 2017
WO 2016037016 A1
10 March 2016
AU 2015311816 A1
CA 2959404 A1
CN 107073042 A
EP 3189134 A1
JP 2017527285 A
KR 20170055497 A
US 2017071937 A1
WO 2016037016 A1
20 April 2017
10 March 2016
18 August 2017
12 July 2017
21 September 2017
19 May 2017
16 March 2017
10 March 2016
WO 2015168149 A2
05 November 2015
US 2017042842 A1
WO 2015168149 A2
16 February 2017
05 November 2015
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
27 April 2020
Date of mailing of the international search report:
07 May 2020
Authorized officer:
Heiduschat, Carola
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