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1. WO1991006538 - DERIVES D'ACIDE ALCANOIQUES BENZOYLBENZENE, BIPHENYLE ET 2-OXAZOLE SUBSTITUES UTILISES COMME INHIBITEURS DE LA PHOSPHOLIPASE A¿2?(PLA¿2?) ET DE LA LIPOXYGENASE

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[ EN ]

WHAT IS CLAIMED TS:

1. A compound having the formula

A(CH2)nσB
wherein
A is phenoxyethyl, phenoxyphenyl or a group having the formula


wherein
R3
X is -N- or -C- ;

Z is
, -S- or -O- R1 is hydrogen, lower alkyl or phenyl;
R2 is hydrogen or lower alkyl; or
R1 and R2 taken together form a. benzene ring;
R3 is hydrogen or lower alkyl;
n is 1 - 2;
B is



wherein
R4 and R5 are each, independently, hydrogen or lower alkyl;
R6 is halo or nitro;

O R4
R7 is -C-R8 or -CHCOOR5 ;
R8 is lower alkyl;
m is 0 - 3 ;
and the pharmacologically acceptable salts thereof.

2. The compound of Claim 1, having the name l-[2-nitro-4'-(2-quino-linylmethoxy)-[l,l'-biphenyl]4-yl]ethanone.

3. The compound of Claim 1, having the name 2-fluoro-4'-(2-quinolinyl-methoxy-[l,l'-biphenyl]-4-acetic acid.

4. The compound of Claim 1, having the name 3-[4-(2-quinolinyl-methoxy)benzoyl]benzene acetic acid.

5. The compound of Claim 1, having the name 3-[4-(2-naphthalenyl-methoxy)benzoyl]benzene acetic acid.

6. The compound of Claim 1, having the name 5-phenyl-4-[4-(2-quino-linylmethoxy)-phenyl]-2-oxazole propanoic acid.

7. The compound of Claim 1, having the name 4-[4-[2-naphthalenyl-methoxy]phenyl]-5-phenyl-2-oxazole propanoic aeid.

8. The compound of Claim 1, having the name 4-[4-[2-naphthalenyl-methoxy]phenyl]-5-phenyl-2-oxazole propanoic acid methylester.

9. The compound of Claim 1, having the name 4-[4-[(l-methyl-l H-benz-imidazol-2-yl)methoxy]phenyl]-5-phenyl-2-oxazole propanoic acid.

10. A process for preparing a compound of Claim 1 comprising




an ester function;
with a compound of formula
A(CH2)n-X
where A and n are as defined above and X is a leaving group, and, if necessary, hydrolyzing the product, to give a product wherein R5 is hydrogen or lower alkyl; or
b) hydrolyzing a compound of formula I, II, IH or IV which contains the -COOR5 moiety, wherein R-5 is lower alkoxy, to give a compound wherein R5 is hydrogen or a pharmacologically acceptable salt thereof;
c) converting a compound of formula I, II, III or IV to a pharmacologically acceptable salt.

11. A process as claimed in Claim 10 substantially as hereinbefore described and illustrated in any one of Examples IC, 2F, 2G, 3G, 3H, 4A, 4B, 5F, 5G, 6A, 6B, 7A and 7B.