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1. ZA1992/03213 - POLYPEPTIDES WITH AFFINITY TO LIPOPOLYSACCHARIDES AND THEIR USES

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]
CLAIMS :
1. A polypeptide represented by the following
formula
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
A 1-A2-Cys-A2-A 3~A 3-Cys-A 2-A J-Gly-A 1-Cys-A 2-A3-A3-Cys-A 4-A j

or salt thereof in which
A, is a hydrogen or at least one and no more than two amino acids selected from the group consisting of lysine and arginine,
A2 is a tyrosine, phenylalanine or tryptophan
residue,
A3 is an arginine or lysine residue,
A4 is at least one and no more than two amino
acids selected from the group consisting of lysine and arginine,
A5 is an -OH or an NH2,
Cys is a cysteine residue, and
Gly is a glycine residue.

2. The polypeptide or salt thereof of claim 1
in which A, is a hydrogen.

3. The polypeptide or salt thereof of claim 1
in which Aj is at least one amino acid selected from
the group consisting of lysine and arginine.

4. The polypeptide or salt thereof of claim 1
in which Aj is two amino acids, in which said amino
acids are selected from the group consisting of lysine and arginine.

5. The polypeptide or salt thereof of claim 1
in which A4 is at least one amino acid selected from
the group consisting of lysine and arginine.

S6691.1

6. The polypeptide or salt thereof of claim 1
in which A4 is two amino acids, in which said amino
acids are selected from the group consisting of lysine and arginine.

7. The polypeptide or salt thereof of claim 1
in which the cysteine residues at the 3- and 16-positions are linked through a disulfide linkage.

8. The polypeptide or salt thereof of claim 1
in which the cysteine residues at the 7- and 12-positions are linked through a disulfide linkage.

9. A polypeptide represented by the following
formula
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
A,-A2-Cys-A2-A3-A3-Cys-A2-A3-Gly-A2-Cys-A2-A3-A3-Cys-A4-A5

or salt thereof in which
Aj is a hydrogen or at least one and no more than two amino acids selected from the group
consisting of lysine and arginine,
A2 is a tyrosine, phenylalanine or tryptophan residue,
A3 is an arginine or lysine residue,
A, is at least one and no more than two amino acids selected from the group consisting of lysine and arginine,
Aj is an -OH or an NH2,
Cys is a cysteine residue, and
Gly is a glycine residue; and the cysteine
residues at the 3- and 16-positions are linked through a disulfide linkage, and the cysteine residues at the 7- and 12-positions are linked through a disulfide
linkage.

86691.1

10. A pharmaceutical composition for inhibiting
HIV activity in a patient comprising an effective
amount of the polypeptide or salt thereof of claim 1
and a pharmaceutical carrier.

11. A pharmaceutical composition for inhibiting
HIV activity in a patient comprising an effective
amount of the polypeptide or salt thereof of claim 9
and a pharmaceutical carrier.

12. A polypeptide or salt thereof according to
claim 1 substantially as described in any one of the
illustrative Examples.

13. A polypeptide or salt thereof according to
claim 9 substantially as described in any one of the
illustrative Examples.

DATED THIS 4TH DAY OF MAY 1992



SPOOR AND FISHER

PATENT ATTORNEYS FOR THE APPLICANT

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