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1. WO2011059670 - SYSTÈME DE RECONNAISSANCE DE SOUS-REMPLISSAGE POUR UN BIODÉTECTEUR

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

WHAT IS CLAIMED IS:

1 . A method for assessing the volume of a sample in a biosensor, comprising:

applying a regular polling sequence;

detecting the presence of a sample;

applying an extended polling sequence;

detecting whether a sample volume is sufficient for analysis of at least one analyte in the sample;

indicating when a sample volume is insufficient for analysis of at least one analyte in the sample; and

applying a test excitation signal when the sample volume is sufficient for analysis of at least one analyte in the sample.

2. The method of claim 1 , the extended polling sequence having at least one different extended input pulse.

3. The method of claim 1 ,

where the detecting the presence of the sample includes detecting when at least one regular output pulse reaches at least one sample threshold, and

where the detecting whether the sample volume is sufficient for the analysis of the at least one analyte in the sample includes detecting when at least one different extended output pulse reaches at least one volume threshold.

4. The method of any one of Claims 1 through 3, further comprising:

detecting at least one of a selected volume and a range of volumes; and counting a delay period when the sample volume is insufficient,

where the detecting of whether the sample volume is sufficient for the analysis of the at least one analyte in the sample occurs after the delay period.

5. The method of any one of Claims 1 through 4, further comprising determining the concentration of the at least one analyte in the sample.

6. The method of any one of Claim 1 through 5, the test excitation signal having at least one test input pulse with a test amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence.

7. The method of any one of Claims 1 through 6, where a last pulse in the extended polling sequence is a different extended pulse.

8. The method of Claim 2,

the regular polling sequence having at least one regular input pulse; and

the extended polling sequence having at least one similar extended input pulse, where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of the at least one regular input pulse, and

where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

9. The method of any one of Claims 1 through 5 or 7,

the regular polling sequence having at least one regular input pulse; and

the extended polling sequence having at least one cycle, where each cycle has at least one similar extended input pulse and at least one different extended input pulse, and where a last pulse in each cycle is preferably a different extended pulse.

10. The method of Claim 9 where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of the at least one regular input pulse, and where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

1 1 . The method of any one of claims 1 through 1 0, where the indicating when the sample volume is insufficient for analysis of the at least one analyte in the sample includes:

stopping the test excitation signal;

requesting a user to add more sample

applying another regular polling sequence to a larger sample;

detecting the presence of a larger sample;

applying another extended polling sequence having at least one different extended input pulse to the larger sample; and

detecting whether the larger sample has a sample volume sufficient for analysis of at least one analyte in the sample.

12. The method of Claim 3, further comprising:

detecting an initial extended output pulse that does not reach at least one more volume thresholds;

counting a delay period from the initial extended output pulse; and detecting a later extended output pulse after the delay period that does reach one or more volume thresholds.

1 3. The method of any one of the preceding Claims, where the regular and extended polling sequences and the test excitation signal are part of a gated amperometry electrochemical analysis.

14. A biosensor with an underfill recognition system, comprising:

a sensor strip having a sample interface on a base, where the sample interface is in electrical communication with a working electrode and a counter electrode, the working and counter electrodes positioned in a reservoir formed by the base; and

a measuring device having a processor connected to a sensor interface, where the sensor interface has a signal generator, and where the sensor interface has electrical communication with the sample interface; and

where the processor directs the signal generator to apply a regular polling sequence,

where the processor detects the presence of a sample,

where the processor directs the signal generator to apply an extended polling sequence,

where the processor detects whether a sample volume is sufficient for analysis of at least one analyte in the sample,

where the processor directs the signal generator to apply a test excitation signal when a sample volume is sufficient for analysis of at least one analyte in the sample, and

where the processor determines the concentration of at least one analyte in a sample in response to a test output signal.

1 5. The biosensor of Claim 14, further comprising:

a comparator connected to the processor and the sensor interface, where the comparator detects when at least one regular output pulse reaches at least one sample threshold, and

where the comparator detects when at least one different extended output pulse reaches at least one volume threshold.

1 6. The biosensor of Claims 14 or 1 5, where the processor directs the signal generator to apply a test excitation signal having at least one test input pulse with a test amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence.

1 7. The biosensor of any one of Claims 14 through 1 6, where the processor detects at least one of a selected volume and a range of volumes.

18. The biosensor of any one of Claims 14 through 1 7, where a last pulse in the extended polling sequence is a different extended pulse.

1 9. The biosensor of any one of Claims 14 through 18,

where the extended polling sequence has at least one similar extended input pulse and at least one different extended pulse,

where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence, and

where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

20. The biosensor of any one of Claims 14 through 1 9, where the extended polling sequence has at least one cycle, where each cycle has at least one similar extended input pulse and at least one different extended input pulse.

21 . The biosensor of Claim 20,

where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence, and

where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse, and where a last pulse in each cycle preferably is a different extended pulse.

22. The biosensor of any one of the preceding Claims,

where the processor counts a delay period when sample volume is insufficient; and

where the processor detects whether a sample volume is sufficient for analysis of at least one analyte in the sample after the delay period.

23. The biosensor of any one of the preceding Claims, further comprising:

a display connected to the processor,

where the processor shows an error signal on the display in response to an underfill condition,

where the processor stops the test excitation signal,

where the processor requests a user to add more sample, where the processor directs the signal generator to apply another regular polling sequence,

where the processor detects when at least one regular output pulse reaches at least one sample threshold,

where the processor directs the signal generator to apply another extended polling sequence,

where the processor detects when at least one different extended output pulse reaches at least one volume threshold, and

where the processor directs the signal generator to apply a test excitation signal when a sample volume is sufficient for analysis of at least one analyte in a sample.

24. The biosensor of any one of the preceding Claims, where the counter electrode includes a sub-element.

25. A method for assessing the volume of a sample in a biosensor, comprising:

applying a regular polling sequence;

detecting the presence of a sample;

applying an extended polling sequence having at least one different extended input pulse; and

detecting whether a sample volume is sufficient for analysis of at least one analyte in the sample.

26. The method of Claim 25, further comprising applying a test excitation signal when the sample volume is sufficient for analysis of the at least one analyte in the sample.

27. The method of Claim 26, further comprising determining the concentration of the at least one analyte in the sample.

28. The method of Claim 26, where the regular and extended polling sequences and the test excitation signal are part of a gated amperometry electrochemical analysis.

29. The method of Claim 26, the test excitation signal having at least one test input pulse with a test amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence.

30. The method of Claim 25, further comprising detecting at least one of a selected volume and a range of volumes.

31 . The method of Claim 25, where a last pulse in the extended polling sequence is a different extended pulse.

32. The method of Claim 25,

the regular polling sequence having at least one regular input pulse; and

the extended polling sequence having at least one similar extended input pulse, where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of the at least one regular input pulse, and

where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

33. The method of Claim 25,

the regular polling sequence having at least one regular input pulse; and

the extended polling sequence having at least one cycle, where each cycle has at least one similar extended input pulse and at least one different extended input pulse.

34. The method of Claim 33 where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of the at least one regular input pulse, and where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

35. The method of Claim 33, where a last pulse in each cycle is a different extended pulse.

36. The method of Claim 25, further comprising:

counting a delay period when sample volume insufficient; and

detecting whether a sample volume is sufficient for analysis of at least one analyte in the sample after the delay period.

37. The method of Claim 25, further comprising indicating when the sample volume is insufficient for analysis of the at least one analyte in the sample.

38. The method of Claim 37, further comprising:

stopping the test excitation signal;

requesting a user to add more sample

applying another regular polling sequence;

detecting the presence of a larger sample;

applying another extended polling sequence having at least one different extended input pulse to the larger sample; and

detecting whether the larger sample has a sample volume sufficient for analysis of the at least one analyte in a sample.

39. The method of Claim 25, further comprising improving at least one of a sample output signal and a volume output signal with at least one mediator.

40. The method of Claim 39, where the at least one mediator includes a two electron transfer mediator.

41 . A method for assessing the volume of a sample in a biosensor, comprising:

applying a regular polling sequence;

detecting when at least one regular output pulse reaches at least one sample threshold;

applying an extended polling sequence;

detecting when at least one different extended output pulse reaches at least one volume threshold;

indicating when a sample volume is insufficient for analysis of at least one analyte in the sample; and

applying a test excitation signal when the sample volume is sufficient for analysis of the at least one analyte in the sample.

42. The method of Claim 41 , where a last pulse in the extended polling sequence is a different extended pulse.

43. The method of Claim 41 , further comprising:

applying at least one similar extended input pulse with an extended amplitude that is essentially the same as a regular amplitude of the at least one regular input pulse; and

applying at least one different extended pulse with another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

44. The method of Claim 43, further comprising applying a test excitation signal having at least one test input pulse with a test amplitude that is essentially the same as the regular amplitude of the at least one regular input pulse.

45. The method of Claim 43, the extended polling sequence having at least one cycle, where each cycle has at least one similar extended input pulse and at least one different extended input pulse.

46. The method of Claim 45, where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of the at least one regular input pulse, and where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

47. The method of Claim 45, where a last pulse in each cycle is a different extended pulse.

48. The method of Claim 41 , further comprising:

detecting an initial extended output pulse that does not reach at least one more volume thresholds;

counting a delay period from the initial extended output pulse; and detecting a later extended output pulse after the delay period that does reach one or more volume thresholds.

49. The method of Claim 41 , further comprising:

stopping the test excitation signal;

requesting a user to add more sample

applying another regular polling sequence to a larger sample;

detecting when at least one regular output pulse from the larger sample reaches at least one sample threshold;

applying an extended polling sequence to the larger sample;

detecting when at least one different extended output pulse from the larger sample reaches at least one volume threshold; and

applying a test excitation signal to the larger sample when the sample volume is sufficient for analysis of at least one analyte in a sample

50. The method of Claim 41 , further comprising improving at least one of a sample output signal and a volume output signal with at least one mediator.

51 . The method of Claim 50, where the at least one mediator comprises a two electron transfer mediator.

52. The method of Claim 41 , further comprising determining the concentration of at least one analyte in a sample.

53. The method of Claim 52, where the regular and extended polling sequences and the test excitation signal are part of a gated amperometry electrochemical analysis.

54. A biosensor with an underfill recognition system, comprising:

a sensor strip having a sample interface on a base, where the sample interface is adjacent to a reservoir formed by the base; and

a measuring device having a processor connected to a sensor interface, where the sensor interface has a signal generator, and where the sensor interface has electrical communication with the sample interface; and

where the processor directs the signal generator to apply a regular polling sequence,

where the processor detects the presence of a sample,

where the processor directs the signal generator to apply an extended polling sequence,

where the processor detects whether a sample volume is sufficient for analysis of at least one analyte in the sample,

where the processor directs the signal generator to apply a test excitation signal when a sample volume is sufficient for analysis of at least one analyte in the sample, and

where the processor determines the concentration of at least one analyte in a sample in response to a test output signal.

55. The biosensor of Claim 54, further comprising:

a comparator connected to the processor and the sensor interface, where the comparator detects when at least one regular output pulse reaches at least one sample threshold, and

where the comparator detects when at least one different extended output pulse reaches at least one volume threshold.

56. The biosensor of Claim 54, where the processor directs the signal generator to apply a test excitation signal having at least one test input pulse with a test amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence.

57. The biosensor of Claim 54, where the processor detects at least one of a selected volume and a range of volumes.

58. The biosensor of Claim 54, where a last pulse in the extended polling sequence is a different extended pulse.

59. The biosensor of Claim 54,

where the extended polling sequence has at least one similar extended input pulse and at least one different extended pulse,

where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence, and

where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

60. The biosensor of Claim 54, where the extended polling sequence has at least one cycle, where each cycle has at least one similar extended input pulse and at least one different extended input pulse.

61 . The biosensor of Claim 36,

where the at least one similar extended input pulse has an extended amplitude that is essentially the same as a regular amplitude of at least one regular input pulse of the regular polling sequence, and

where the at least one different extended pulse has another extended amplitude that is not the same as the regular amplitude of the at least one regular input pulse.

62. The biosensor of Claim 61 , where a last pulse in each cycle is a different extended pulse.

63. The biosensor of Claim 54,

where the processor counts a delay period when sample volume is insufficient; and

where the processor detects whether a sample volume is sufficient for analysis of at least one analyte in the sample after the delay period.

64. The biosensor of Claim 54, further comprising:

a display connected to the processor,

where the processor shows an error signal on the display in response to an underfill condition,

where the processor stops the test excitation signal,

where the processor requests a user to add more sample, where the processor directs the signal generator to apply another regular polling sequence,

where the processor detects when at least one regular output pulse reaches at least one sample threshold,

where the processor directs the signal generator to apply another extended polling sequence,

where the processor detects when at least one different extended output pulse reaches at least one volume threshold, and

where the processor directs the signal generator to apply a test excitation signal when a sample volume is sufficient for analysis of at least one analyte in a sample.

65. The biosensor of Claim 54, further comprising a sample interface with at least two electrodes and at least one mediator.

66. The biosensor of Claim 54, further comprising a sample interface with a counter electrode and a working electrode.

67. The biosensor of Claim 66, where the counter and the working electrodes include a redox couple.

68. The biosensor of Claim 66, where the counter electrode has a sub-element.

69. The biosensor of Claim 68, further comprising a mediator disposed between the counter and working electrodes, where a mediator is not substantially disposed between the working electrode and the sub-element.

70. The biosensor of Claim 69, where the mediator includes a two electron transfer mediator.

71 . The biosensor of Claim 69, where the regular and extended polling

sequences and the test excitation signal are part of an electrochemical sensor analysis.