WO/2015/026254 MOLECULAR TAG CONTAINING DNA MOLECULES AND PROCESS FOR MARKING AND IDENTIFYING THE TAG||WO||26.02.2015|
||PCT/PT2014/000056||UNIVERSIDADE DE AVEIRO||MARCIAL GOMES, Newton Carlos|
The present invention relates to a molecular tag and a process for marking various materials and liquid media using chimeric deoxyribonucleic acid (DNA) molecules for formulating tags, and using polymerase chain reaction (PCR) techniques and denaturing gradient gel electrophoresis (DGGE) for identifying the tag. The molecular tag for marking a substrate, described in the present invention, comprises: a mixture of a plurality of DNA molecules, each of which comprises a GC-clamp DNA fragment as identifier segment and a microbial DNA fragment as encoding segment, in which at least two of said microbial DNA fragments originate from different microorganisms; and a vehicle for supporting said mixture. Thus, the present invention relates to the field of tracing and identifying various materials, applicable to any type of activity in which the tracing or certification of origin might be necessary.
WO/2015/026253 LAMINATED HORSESHOE WITHOUT METALLIC LAYERS||WO||26.02.2015|
||PCT/PT2014/000055||AMORIM CORK COMPOSITES, S.A.||OLIVEIRA, Carlos Alberto Gomes De|
A laminated horseshoe without metallic layers is disclosed comprising a first equine hoof connection layer (1) which, in use, is intended to be in contact with an equine hoof; a fifth traction material layer (5), which, in use, is intended to be in contact with the ground; and a central core made of a second basalt fibre layer (2) arranged on the first layer (1), a third agglomerated cork layer (3) arranged on said second layer (2) and a fourth basalt fibre layer (4) arranged between said third and fifth layers(3, 5). The horseshoe can be applied in equine hooves by horseshoe nails or glue and provides a very good ratio of hardness to shock absorption in comparison with prior art horseshoes, providing a better horse performance in demanding competitions.
WO/2015/026252 MULTIFUNCTIONAL SUPERPARAMAGNETIC NANOSYSTEM AS CONTRAST AGENT FOR MAGNETIC RESONANCE IMAGING AND ITS PRODUCTION METHOD||WO||26.02.2015|
||PCT/PT2014/000054||INSTITUTO SUPERIOR TECNICO||GONCALVES, MARIA Clara Henriques Baptista|
The present invention concerns a multifunctional superparamagnetic nanosystem and its production method for nano-biomedical imaging, human and animal, intended to be used as contrast agent (CA) for Magnetic Resonance Imaging (MRI). Furthermore, it can be associated with therapies such as hyperthermia, and to the transport and targeted release of selected drugs, by conjugation with biomolecules. The multifunctional superparamagnetic nanosystem can be used as negative contrast agent, reducing the T2 value of tissues in MRI, found on the extremely high magnetic moment, under the action of a magnetic field. It can also be used as positive contrast agent. Its efficiency as MRI contrast agent allows for the usage of clinical dosages that are much lower than the ones currently administered to patients who undergo this diagnosis technique. The multifunctional superparamagnetic nanosystem provides a technological platform for several applications in nano- biomedical imaging. It is biocompatible and biodegradable, and its production is free of organic compounds and surfactants.
WO/2015/023194 COMBINED MECHANISM FOR ARTICULATION AND LATCH LOCKING/UNLOCKING FOR BUILT-IN LOCKS ON STANDARD DOORS||WO||19.02.2015|
||PCT/PT2014/000048||BARBOSA, Mafalda Botequilha||BARBOSA, Carlos Manuel Rosa|
The utility model presented is a combined mechanism for articulation and latch locking/unlocking for built-in locks on standard doors. The mechanism allows the user, upon applying vertical force, to retract the latch of the lock horizontally. The aforementioned mechanism consists of a perforated part and trigger (1) that initiates a rotational movement produced by a ratchet rod (2) perpendicular to the surface of the lock and present on each of its sides. Upon being moved vertically, it forces the part (1) to turn in a circular motion, thereby retracting the latch shaft (3) horizontally. The aforementioned ratchet rod (2) ends in a quadrangular parallelepiped, allowing the use of existing standard door knobs, thereby guaranteeing the aesthetics of the door. The utility model presented is applicable in the manufacture of built-in locks for standard doors.
WO/2015/016730 METHOD FOR PRODUCTION OF FLEXIBLE PANELS OF HYDROPHOBIC AEROGEL REINFORCED WITH FIBRE FELTS||WO||05.02.2015|
||PCT/PT2014/000053||ACTIVE AEROGELS, UNIPESSOAL, LDA.||BATISTA OCHOA, Marta Leonor|
This invention describes a method for producing large pieces of aerogel. A felt of fibres is added to the silica solution, which is prepared from a trialkoxysilane (methyltrimethoxysilane and methyltriethoxysilane ). The most relevant aerogel properties produced with these trialkoxysilanes are flexibility, low density, low thermal conductivity and hydrophobicity; these properties are kept from cryogenic temperatures up to at least 350°C. Felts are used to improve the mechanical strength of aerogels, allowing the manufacture of pieces with large dimensions, which has been a major limitation for the application of these materials. The applications of the material described herein include thermal insulation for the construction, oil and gas, cryogenics, thermoelectric, aeronautics and space sectors. However, due to high specific surface area, this material is also important for applications in pharmaceuticals and wastewater treatment.
WO/2015/016729 UREA COMPOUNDS AND THEIR USE AS FAAH ENZYME INHIBITORS||WO||05.02.2015|
||PCT/PT2014/000052||BIAL - PORTELA & Cª, S.A.||KISS, Laszlo Erno|
There is provided a compound having Formula I:(I) wherein: R1 is aryl which is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy, or R1 is aryl which is substituted with a second aryl group or an aryloxy group, wherein the second aryl group or the aryloxy group is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy; R2 is C1-4 alkyl; R3 is selected from hydroxyl and OSO2CH3; R4 and R5 are independently selected from hydrogen, hydroxyl and halogen; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; wherein when R3 is hydroxyl and R4 and R5 are not hydroxyl, the optionally substituted aryl group, second aryl group or aryloxy group of R1 is substituted with one or more hydroxyl groups or C1-4 alkoxy groups, or wherein when R3 is hydroxyl, one of R4 and R5 is hydroxyl, provided that the compound is not N-(1-benzylpiperidin-4-yl)-4-(3,4-dihydroxyphenyl)-N-methyl-1H-imidazole-1-carboxamide hydrobromide. The compound may be used as an inhibitor of fatty acid amide hydrolase.
WO/2015/016728 UREA COMPOUNDS AND THEIR USE AS FAAH ENZYME INHIBITORS||WO||05.02.2015|
||PCT/PT2014/000051||BIAL - PORTELA & Cª, S.A.||KISS, Laszlo Erno|
A compound having Formula (I): wherein: R1 is selected from hydrogen, halogen, hydroxyl and C1-4 alkoxy; R2 is selected from hydrogen, halogen, hydroxyl and C1-4 alkoxy; R3 is C1-4 alkyl; R4 is aryl which is substituted with a group selected from OSO2NH2, NHCONH2, NHSO2NH2, NHSO2C1-4 alkyl and CONH2; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; provided that the compound is not N-(1-benzylpiperidin-4-yl)-N-methyl-4-(4-(sulfamoylamino)phenyl)-1H-imidazole-1-carboxamide or N-(1-benzylpiperidin-4-yl)-N-methyl-4-(3-(methylsulfonamido)phenyl)-1H-imidazole-1-carboxamide. The compound may be used as an inhibitor of fatty acid amide hydrolase.
WO/2015/016727 ORAL DISPERSIBLE FILMS||WO||05.02.2015|
||PCT/PT2014/000050||BLUEPHARMA - INDUSTRIA FARMACÊUTICA, S.A.||SILVA BORGES, Ana Filipa|
Described herein are orodispersible films comprising a film forming hydrophobic polymer, a disintegrant, a plasticizer and a stabilizer.
WO/2015/012708 IMIDAZOLECARBOXAMIDES AND THEIR USE AS FAAH INHIBITORS||WO||29.01.2015|
||PCT/PT2014/000049||BIAL - PORTELA & Cª, S.A.||ROSA, Carla Patrícia da Costa Pereira|
A compound having a structure selected from the following: or a pharmaceutically acceptable salt thereof. The compound may be used as an inhibitor of fatty acid amide hydrolase.
WO/2015/005813 METHOD FOR PRODUCTION OF LOCAL ILLUMINATION PATCH CORD AND CORRESPONDING PATCH CORD||WO||15.01.2015|
||PCT/PT2014/000010||FAMOLDE - FABRICAÇÃO E COMERCIALIZAÇÃO DE MOLDES, S.A.||HENRIQUES MARTINS, Joaquim|
Present invention discloses a method of producing a local illumination patch cord and the corresponding patch cord, based on the technology of a multi-fiber optic cable, from the entrance of supplies till the final product - the local illumination patch cord. Among various available cables, none of those on which tests were carried out met the following final product requirements: flexibility, light efficiency, and decrease of factors affecting its resistance, namely the heat. In opposition to the current accessories available in the market, present invention decentralizes the thermal filter from the cable to the coupling, enabling heat dissipation before entering the illumination cable. Regarding the luminous efficiency, present invention defines a technique with a more effective manner of aggregating the multi-fibers of the cable, with significant savings in production times, and raises polishing quality to the highest level of light transmission.