WO/2015/057092 TROCAR WITH A FREEZING PROBE||WO||23.04.2015|
||PCT/PL2014/050066||WARSZAWSKI UNIWERSYTET MEDYCZNY||STRULAK, Łukasz|
The subject of the present invention is sharp/blunt trocar for freezing tissues containing sealed channels for conducting refrigerant in a continuous flow, connected with a pump and a container for the refrigerant, terminating in a freezing head, wherein the freezing head possesses at least one elastic surface (2), which changes shape and distends as a result of pumping refrigerant under pressure through the trocar forming a decompression chamber (5), in which refrigerant undergoes decompression causing the elastic surface (2) of the freezing head to cool, and the aforementioned elastic surface (2) is capable of fitting itself to the tissue being subjected to freezing (3). The subject of the present invention is also a the use of a sharp/blunt trocar in the downregulation of arterial blood pressure in the renal artery.
WO/2015/057090 METHOD FOR DETECTION OF DECREASED SUSCEPTIBILITY FOR ANTICANCER ADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS||WO||23.04.2015|
||PCT/PL2014/000112||WROCŁAWSKIE CENTRUM BADAŃ EIT + SP. Z O.O.||PUŁA, Bartosz|
The invention relates to a method for detection of decreased susceptibility for anticancer adjuvant chemotherapy with cytostatic from the group of oxazaphosphorines and antibiotic from the group of anthracyclines in breast cancer patients, according to which the evaluation of PIP gene expression is performed with the use of real-time PCR method on the isolated total RNA in the sample of tissue material taken from patient from primary tumour of ductal breast cancer, wherein the statistically significant lower expression of PIP mRNA indicates decreased susceptibility for anticancer adjuvant chemotherapy with cytostatic from the group of oxazaphosphorines and antibiotic from the group of anthracyclines. The invention provides a prediction test, which enables rapid classification of patients in terms of their responsiveness for adjuvant chemotherapy and thus the undertaking of appropriate therapeutic intervention.
WO/2015/057091 SELF-SUPPORTING THERMAL PANEL||WO||23.04.2015|
||PCT/PL2014/000113||IQ-ENERGY S.A.||STRYJSKI, Roman|
The subject of the invention is self-supporting thermal panel designed for heating and cooling rooms. The panel casing is made of two metal sheets located opposite each other and joined in such a way that between these sheets is created space for heating-cooling liquid agent flow which is exchanged by opposite located collectors equipped with hydraulic couplings. In accordance with the invention at least one of metal sheets (2, 3) has at least one hollow (4, 17) directed inside the panel (1) and flat oval convexity (10) located along panel side edges (6, 7) which are its collectors (1 1, 12) exchanging heating-cooling liquid agent, and at least one of metal sheets (2, 3) has near its side edges (7) the redrawing joints creating hollow (14) for gasket or sealing substance (15) and the side edges (6,7) of the sheets (2, 3) are profiled upwards at the right angle and joined each other by the redrawing joints or rivets (8).
WO/2015/053643 MULTI-MEMBER CHANNEL BAR||WO||16.04.2015|
||PCT/PL2014/050062||SIELSKI, Kazimierz||SIELSKI, Kazimierz|
The invention relates to a multi-member channel bar used as a passageway for power and telecommunications cables, as well as for use in construction. The multi-member channel bar, comprising openings along its entire length and provided with a connector (1 ) in the shape of a rectangular prism having through-holes (19) extending in crossing directions, is characterized in that it comprises superimposable members, each having an upper superimposable connecting section (2) and a widened lower superimposable connecting section (3), and slide-in members, each having an inner slide-in connecting section (14) and a widened slide-in connecting section (13). Each superimposable member, at its widened lower superimposable connecting section (3), has a tongue (7) provided with a latch (8) and cut-outs (12) formed above the tongue (7) and leading projections (5) formed below the tongue (7), while each superimposable member, at its upper superimposable connecting section (2), has leading projections (4) under which there is an opening (11 ) for the latch (8) and below the opening (11 ) there are holes (6). Each slide-in member at its widened slide-in connecting section (13), has projections (15) and cut-outs (17), and, at its inner slide-in connecting section (14), it has projections (16) and cut-outs (18).
WO/2015/053641 PRO-HEALTHY FOOD PRODUCT||WO||16.04.2015|
||PCT/PL2013/050036||ZACHODNIOPOMORSKI UNIWERSYTET TECHNOLOGICZNY W SZCZECINIE||BARTKOWIAK, Artur|
Pro-healthy food product, composed of microcapsules with immobilized cells of probiotic microorganisms according to the present invention characterized in that it has form of a powder containing 22.3 - 60 weight % of the source of essential unsaturated fatty acids (EF A/UFA) and 106 - 1013 live cells of probiotic microorganisms in a gram of the product and up to 5 weight % of emulsifier from the group of fatty acids and sorbitol esters and/or oxyethynelated fatty acids and sorbitol esters. Microcapsule envelope is formed by 10-50 weight % of natural polymer or modified natural polymer and 3-60 weight % of maltodextrin or mixture of maliodexirins with various values of Dextrose Equivalent and/or glucose syrup. The envelope composes 30-63 weight % of a microcapsule.
WO/2015/053642 METHOD OF PRODUCING PRO-HEALTHY FOOD PRODUCT||WO||16.04.2015|
||PCT/PL2013/050037||ZACHODNIOPOMORSKI UNIWERSYTET TECHNOLOGICZNY W SZCZECINIE||BARTKOWIAK, Artur|
A method of producing pro-healthy food product in form of an immobilisate according to the present invention based on the production of an emulsion, its homogenization and then drying, is characterized in that natural polymers or modified natural polymers, maltodextrin or mixture of maltodextrins with different Dextrose Equivalents and/or glucose syrup are added into water at total amount of 10.6 – 30 weight %, forming continuous phase during turbulent mixing. Dispersed phase is slowly added to continuous phase while mixing intensively. Dispersed phase is formed during short mixing of the source of essential unsaturated fatty acids (UFA/EFA) with an emulsifier with high HLB based on oxyethynelated fatty acids and sorbitol esters and/or with an emulsifier with low HLB based on fatty acids and sorbitol esters. The ratio of high HLB emulsifier is from 0 to 1 and total concentration of emulsifiers in dispersed phase is lower than 17.6 weight %. The combination of continuous and dispersed phases forms a pre-emulsion with volumetric ratio of dispersed phase of 0.1-0.3. Then the pre-emulsion is subjected to homogenization, thus obtaining primary emulsion. A biomass of live probiotic microorganisms is added to primary emulsion and mixed gently to obtain emulsion, which is next subjected to spray-drying at air temperature of 140 - 80°C and outlet temperature 50 - 85°C thus obtaining the powder in form of microcapsules with immobilized unsaturated fatty acids (UFA/EFA) and probiotic microorganisms.
WO/2015/050467 2',3'-DIDEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF||WO||09.04.2015|
||PCT/PL2014/050009||ADAM MICKIEWICZ UNIVERSITY||CELEWICZ, Lech|
The subject matter of the invention is novel 2',3'-dideoxy-5-fluorouridine derivatives of general formula 1. wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In the second aspect, the subject matter of the invention is a process for the manufacture of 2',3'-dideoxy-5-fluorouridine derivatives of general formula 1. In the third aspect, the subject matter of the invention is an application of 2',3'-dideoxy-5-fluorouridine derivatives of general formula1 of the invention in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer.
WO/2015/050468 2,3'-Anhydro-2'-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application||WO||09.04.2015|
||PCT/PL2014/050050||ADAM MICKIEWICZ UNIVERSITY||CELEWICZ, Lech|
The subject matter of the invention is novel 2,3'-anhydro-2'-deoxy-5-fluorouridine derivatives of general formula (1) where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3'-anhydro-2'-deoxy-5-fluorouridine derivatives of general formula (1). In a third aspect, the subject matter of the invention is an application of 2,3'-anhydro-2'-deoxy-5-fluorouridine derivatives of general formula (1) in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
WO/2015/050466 SYSTEM OF DEVICES FOR INTERSPINOUS STABILISATION OF THE SPINE||WO||09.04.2015|
||PCT/PL2014/000109||PRAKTYKA LEKARSKA ESPINEN PIOTR SZYDLIK||SZYDLIK, Piotr|
The invention relates to a system of devices for interspinous stabilisation of the spine. The system's feature is simultaneous application of interspinous devices (100, 101 and 102) and rails (200, 201) for multi-level fixation of a spine (A) comprising at least three spinous processes (B) at two levels so that at least two interspinous devices (100, 101 and 102) are placed between the spinous processes (B) on at least two levels of the spine (A) and two rails (200, 201) mounted by them, one on each side of the spinous processes (B). The invention relates also to a method of spinal stabilisation.
WO/2015/050465 AN ELECTRONIC POWER SWITCH FOR A POWER SUPPLY CONTROL SYSTEM BASED ON DATA COMMUNICATION NETWORKS||WO||09.04.2015|
||PCT/PL2014/000108||BNT SP. Z O.O.||BĄK, Piotr|
An electronic power switch la comprises a housing 2a in which a control system (6) is located and on which a control button 3a is mounted in a dismountable manner, wherein at least one control switch 4 switchable by means of said control button is located under said control button, and which further comprises a parameter setting system 5 of said control system located under said control button. The control system may be an addressable system of a data communication network, and the parameter setting system may constitute a network address definement system of the addressable control system, which advantageously comprises a transmitter/ receiver for power line communication (PLC).