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Resultados 1-10 de 2.196 para loscriterios:(ANID:CZ* AND CTR:WO) Oficina(s):all Idioma:ES separación automática de palabras en lexemas: true maximize
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TítuloPaísFecha de publicación
Clasificación InternacionalNº de solicitudSolicitanteInventor/a
1. WO/2017/025068 NOOZLE WITH ELLIPTICAL ORIFICE INLET PROFILEWO16.02.2017
H05H 1/34
PCT/CZ2016/050028THERMACUT, S.R.O.CROWE, Georg A.
A nozzle for a plasma arc torch symmetrically disposed about a nozzle axis and comprising a nozzle orifice centered on the nozzle axis and having a generally cylindrical orifice sidewall; a gas-directing surface symmetrically disposed about the nozzle axis and surrounding said orifice; and an inlet joining said gas-directing surface to said orifice sidewall, said inlet having a variable curvature generated by rotation of a substantially elliptical form about the nozzle axis, wherein the substantially elliptical form at least approximates a portion of an ellipse having a major axis and a minor axis, where the ratio of the major axis to the minor axis is greater than 2:1, further wherein said substantially elliptical form is positioned such that said gas-directing surface is substantially tangent to the ellipse at its intersection therewith, and said orifice sidewall is substantially tangent to the ellipse at its intersection therewith.

2. WO/2017/020875 MANUAL STAIR CLIMBER FOR A MECHANICAL WHEELCHAIR AND A METHOD OF USING A MECHANICAL WHEELCHAIR IN CONJUNCTION WITH SUCH MANUAL STAIR CLIMBERWO09.02.2017
A61G 5/06
PCT/CZ2016/000081EURONAL EXPORT S.R.O.VLK, Josef
The manual stair climber for a mechanical wheelchair includes a support structure (6) and a crawler track (7). The track (7) of the stair climber (5) and/or the entire stair climber (5) is shiftable and/or the rear wheel (4) of the wheelchair (10) is relocatable. The assembly of the stair climber (5) installed to the wheelchair (10) includes a transmission (8) which is connected to the track (7) of the stair climber (5), and to a torque transmitter (14). The stair climber (5), which is pivotably fixed to the wheelchair (10), includes a brake (11) which has a progressively increasing effect and is provided with a brake control element (5). The brake disc (12) of the brake (11) is attached to the stair climber (5) which is installed pivotably; and the brake caliper (13) of the brake (11) is attached to the wheelchair (10) and/or vice versa. In the configuration (II) for travelling across a grade-separated obstacle, the rear wheels (4) constitute a torque transmitter (14).

3. WO/2017/020876 SYSTEM FOR SECURING OF SAFETY OF RAILROAD CROSSING AGAINST VEHICLE ENTRY DURING WARNING SIGNALINGWO09.02.2017
B61L 29/30
PCT/CZ2016/000084KRANZ, VladimirKRANZ, Vladimir
According the application of the invention when barriers are lowered, first are lowered barrier in front rails after, in adjustable time delay, that barrier behind rails, what allow to vehicles clear out rail area. Sensor advantageously senses area on rails and in case of any obstruction for railway train delays lowering of barriers or stops it till the time when obstruction leaves the rails. In the same time it transmits alarm into dispatching of train transport and into coming railway train by means of wireless connection. It simultaneously activates alarm siren and advantageously voice announcement calling for releasing of rails.

4. WO/2017/020877 HEADREST OF A VEHICLEWO09.02.2017
B60N 2/48
PCT/CZ2016/000085SKODA AUTO A.S.PROKS, Martin
The invention relates to a headrest of a vehicle, consisting of a foam cushion (2), a lining (1), a housing (3), supports (4), and a cover (5). The headrest comprises lateral parts (6) for comfortably supporting the head of the vehicle occupant. The comfort headrest ensures the safety of the occupant when sleeping in that the headrest prevents the position of the body from changing with respect to the seatbelt. The invention is characterized in that the headrest comprises a tubular frame (7) which is arranged and secured in the housing (3). The lateral parts (6) are secured to both ends of the tubular frame (7) on both sides of the headrest. The tubular frame comprises a friction mechanism (8) which is secured to the housing (3).

5. WO/2017/020878 SOLID FORMS OF AMORPHOUS DOLUTEGRAVIRWO09.02.2017
A61K 9/14
PCT/CZ2016/000086ZENTIVA, K. S.OBADALOVA, Iva
The solution relates to new solid forms of amorphous dolutegravir of formula I, their preparation methods and use in a drug form. These solid forms can be advantageously used to increase the chemical and polymorphic stability of amorphous dolutegravir. Dolutegravir is indicated in combination with other antiretroviral medications for the treatment of adult and adolescent patients over 12 years of age infected by the human immunodeficiency virus (HIV). Dolutegravir inhibits HIV integrase by binding to the active site of the integrase and by blocking the transfer processes of integration of the retroviral deoxyribonucleic acid (DNA), which is important for the replication cycle of HIV. (I)

6. WO/2017/016529 SOLID FORMS OF CERITINIB FREE BASEWO02.02.2017
C07D 401/12
PCT/CZ2016/000082ZENTIVA, K.S.ZVATORA, Pavel
The invention relates to solid forms of 5-chloro-N2-[2-isopropoxy-5-methyl-4-(4-piperidinyl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]-2,4-pyrimidinediamine of formula (I), known as ceritinib, methods of their preparation and use in a dosage form.

7. WO/2017/016530 A METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL] AMINO]PHENYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB)WO02.02.2017
C07D 209/34
PCT/CZ2016/000083ZENTIVA, K.S.MECA, Ludek
The invention relates to a method of synthesizing methyl (Z)-3-[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl] amino]phenyl] amino]phenylmethylene)-oxindole-6-carboxylate of formula (1), known under the generic name of intedanib or nintedanib. The present method comprises a) a reaction of methyl oxindole-6-carboxylate with acetic anhydride at a temperature of 130 - 140°C, providing methyl 1-acetyl-oxindole-6-carboxylate; b) a reaction of methyl 1-acetyl-oxindole-6-carboxylate of with trimethyl orthobenzoate and acetic anhydride in the presence of toluene, providing methyl (E)-1-acetyl-3-(methoxyphenylmethylene)-oxindole-6-carboxylate; c) a reaction (E)-1-acetyl-3-(methoxyphenylmethylene)-oxindole-6-carboxylate with N-(4-aminophenyl)-N,4-dimethyl-1-piperazine acetamide and subsequently with an alkali hydroxide or alkali alkoxide in methanol or ethanol without isolation of the intermediate, providing methyl (Z)-3-[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl] amino]phenylmethylene)-oxindole-6-carboxylate, wherein the reaction is conducted at a temperature of 50 to 100°C. (1)

8. WO/2017/012599 5-SUBSTITUTED-7-[4-(SUBSTITUTED)BENZYL]AMINO-3-ISOPROPYLPYRAZOLO(4,3-D)PYRIMIDINES AS MEDICAMENTSWO26.01.2017
C07D 487/02
PCT/CZ2015/050007USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.KRYSTOF, Vladimir
The present invention relates to 5-substituted-7-[4-(substituted)benzyl]amino-3- isopropylpyrazolo[4,3-d]pyrimidines of formula (I) which are effective inhibitors od cyclin- dependent kinases and exhibit strong anti-inflammatory properties. This invention further relates to processes for their preparation, to pharmaceutical compositions comprising said compounds and to their use for the treatment of antiiflammatory disorders such as rheumatoid arthritis.

9. WO/2017/012600 A PHARMACEUTICAL COMPOSITION CONTAINING VALSARTAN AND SACUBITRIL AND METHODS FOR PREPARATION AND STABILIZATION THEREOFWO26.01.2017
A61K 9/20
PCT/CZ2016/000079ZENTIVA, K.S.DOHNAL, Jiri
The invention relates to orally administered compositions containing Valsartan of formula (I), systematic name (S)-3-methyl-2-(N--{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}- pentanamido)butanoic acid, or its pharmaceutically acceptable salts, and Sacubitril of formula (II), systematic name (2R,4S)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methyl- pentanoic acid ethyl ester, or its pharmaceutically acceptable salts with suitable pharmaceutical excipients, and also to preparation and stabilization thereof, wherein the composition is stored in a pharmaceutical package where an inert atmosphere is maintained by means of nitrogen.

10. WO/2017/008770 ARRANGEMENT OF CENTRAL LOAD - CARRYING TUBE OF MOTOR VEHICLE CHASSIS WITH INTEGRATED ROTARY ELECTRIC MOTOR, METHOD OF ITS PLACEMENT AND USEWO19.01.2017
B60K 1/00
PCT/CZ2016/000035GI4 S.R.O.POLDEN, Robin
Arrangement of central load - carrying tube of motor vehicle chassis with integrated rotary electric motor, method of its placement and use, wherein one or more rotary electric motors (1) are placed inside the tubular structure of the central tube (2) of vehicle chassis. Advantageously, the tubular structure of the central tube (2) of vehicle chassis is further fitted with traction components (5), (6) and (7), which, together with the rotary electric motor, form a compact unit. Use of central load - carrying tube (2) according to claims 1 to 6, fitted with rotary electric motor (1) and traction components, as a chassis of the road, commercial and military vehicles.


Resultados 1-10 de 2.196 para loscriterios:(ANID:CZ* AND CTR:WO) Oficina(s):all Idioma:ES separación automática de palabras en lexemas: true
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