WO/2016/188506 SOLID FORMS OF 5-FLUORO-3-PHENYL-2-[(1S)-1-(9H-PURIN-6-YLAMINO)PROPYL]QUINAZOLIN-4-ONE AND PREPARATION THEREOF||WO||01.12.2016|
||PCT/CZ2016/000056||ZENTIVA, K.S.||KISS, Violetta|
Solid forms of 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-one of formula (I), suitable for oral administration, which comply with pharmaceutical requirements. Preparation and characterization of Crystal Form 1 and Crystal Form 2.
WO/2016/188507 METHOD OF TREATING BIOMASS WITH LASER LIGHT AND APPARATUS FOR PERFORMING THE SAME||WO||01.12.2016|
||PCT/CZ2016/000057||SKOPAL, Jaroslav||SKOPAL, Jaroslav|
Technical problem: Biomass stored in the fermenters is processed insufficiently during anaerobic digestion because the microorganisms cannot decompose lignocellulose compounds forming cell walls of biomass with the desired efficiency. Solution: Lignocellulose compounds present in the biomass are degraded to simpler compounds by means of irradiating with laser light while the said compounds can be processed by the microorganisms more effectively. In addition to it, laser light stimulates the microorganisms that dwell in the biomass that is being decomposed inside the fermenters.
WO/2016/184438 METHOD FOR PRODUCING NANOSTRUCTURED OR MICROSTRUCTURED.MATERIALS AND APPARATUS FOR PRODUCING THEREOF||WO||24.11.2016|
||PCT/CZ2015/000043||ČESKÉ VYSOKÉ UČENÍ TECHNICKÉ V PRAZE||BERAN, Miloš|
The invention relates to a process for producing nanostructured or makrostructured materials and devices for their production. The principle of the invention consists in that a solution, emulsion or liquid suspension of one substance or a mixture of substances or microorganisms optionally saturated with a gas, liquefied gas or supercritical liquid, is fed into an inner space of a disc through a hollow shaft, and by means of the combination of a centrifugal force and fluid pressure occurs the outlet of the liquid through an expansion gap, to form microscopic droplets. The microscopic droplets are subsequently secondarily disintegrated by expansion of the gas comprised therein to smaller droplets, to form an aerosol. The aerosol is subsequently dried by a drying gas stream to form solids. In special cases, when drying some polymers under certain conditions, microfibers or nanofibers can be created instead of corpuscular forms. The subject matter of a device for producing nanostructured and microstructured materials consists in that it comprises a chamber in which a hollow shaft is assembled, on which at least one disc provided with an expansion gap is mounted, wherein the hollow shaft has openings which connect the inner space of the hollow shaft with the expansion gap. The chamber may additionally be provided with an independent feed nozzle.
WO/2016/184440 SPORT EQUIPMENT FOR BIDIRECTIONAL RIDE ON SNOW ON TWO MUTUALLY CONNECTED BOARDS||WO||24.11.2016|
||PCT/CZ2015/000045||STORKAN, Pavel||STORKAN, Pavel|
The technical solution relates to a sports equipment for bidirectional ride on snow on two boards (1) according to Fig. 1, where the boards (1) are interconnected by a coupling mechanism (3) to allow for a better control over the handling of the two boards (1), wherein each board (1) is fixed to one leg of the rider by that the two boards (1) are interconnected permanently or temporarily via the coupling mechanism (3) so that the two boards (1) are parallel to one another in their longitudinal axis (0). In the exemplary embodiment according to Fig. 4, the solution further relates to a sports equipment for bidirectional ride on snow on two boards (1), wherein the coupling mechanism (3) consists of two swing arms (33), two arm holders (31) for mounting the arms (33) to the board (1), the holder (31) with arm (33) and arms (33) themselves are mutually connected to the pivots (32) allowing rotation of the arms (33) at both ends thereof about the axis of symmetry (O) of the boards (1). The arm holders (31) are disposed in a manner that on one board (1) the holder (31) is connected to the board (1) in front of the binding (2), and on the second board (1) the holder (31) is located behind the binding (2), the coupling mechanism (3) thereby being positioned between the bindings (2). This solution avoids the disadvantages of the previous technical solution by allowing a significantly better control over the handling two boards, wherein each is attached to one leg of the rider, characterized in that the two boards are interconnected permanently or temporarily via a coupling mechanism so that the two boards in their longitudinal axis are parallel to one another.
WO/2016/184442 PORTABLE DEVICE USED ESPECIALLY FOR ELECTROFULGURATION AND ELECTRODESICCATION||WO||24.11.2016|
||PCT/CZ2016/050014||COMPEX SPOL. S R. O.||NESPOR, Radek|
The invention described is a portable electrocauter used especially for electrofulguration, electrodesiccation and electrocoagulation. It contains a source of energy and an aplicator. Electrocauter is provided with the source of DC with the maximal current of 1 mA and voltage between 0.8 to 12 kV. The aplicator (1) is provided with precisely aiming finish and the patient is conductively connected with the equipment by disposable grounding electrode while the output of the discharge between the working electrode and the surface of the skin is in the range of 0.3 to 4.0 W.
WO/2016/184441 PLANAR IRRADIATION SOURCE ESPECIALLY FOR INDUCTION AND MONITORING OF PHOTODYNAMIC EFFECT IN VITRO||WO||24.11.2016|
||PCT/CZ2015/000125||UNIVERZITA PALACKÉHO V OLOMOUCI||BAJGAR, Robert|
The planar irradiation source especially for induction and monitoring of photodynamic effect in vitro in samples placed in a bed (3) which is formed with a sealable body (1 ) which is procured with a from above opened central chamber (11 ) modified not only for removable insertion of the bed (3) with analyzed sample but also for above it positioned removable positioning of a semitransparent thin walled irradiation plate (4) which is procured with diode chips (41 ) placed in the rows with mutual hexagonal arrangement whereas the diode chips (41 ) are in parallel connected with a bus (42), which is led along the perimeter of the irradiation plate (4) and is connected with an external power supply, and are placed in the irradiation plate (4) in the way that their light beams are directed straight down toward the bed (3).
WO/2016/184439 APPARATUS FOR PRODUCING NANOFIBRES OR MICROFIBRES||WO||24.11.2016|
||PCT/CZ2015/000044||ČESKÉ VYSOKÉ UČENÍ TECHNICKÉ V PRAZE||BERAN, Miloš|
The invention relates to a device for producing nanofibers or microfibers from solutions, emulsions, liquid suspensions or melts containing a spun substance. The subject matter of the invention consists in that it comprises a chamber in which a hollow shaft is assembled, on which at least one rotating disc with an output gap is mounted. The chamber is generally provided with a source of the flowing gas and a collection area. In an alternative embodiment, the chamber is provided with a number of side by side arranged hollow shafts on which rotating discs are mounted. It is preferred that at least one hollow shaft is provided with two superposed rotating discs. At least one rotating disc is composed of two successive parts, wherein between the upper part and the lower part an outlet gap is formed around the circumference thereof. The size of the outlet gap between the upper part and the lower part of rotating disc may be formed by a spacer element, in particular a spacer ring.
WO/2016/180380 5-SUBSTITUTED 7-[4-(2-PYRIDYL)PHENYLMETHYLAMINO]-3-ISOPROPYLPYRAZOLO4,3-D]PYRIMIDINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS||WO||17.11.2016|
||PCT/CZ2015/050006||USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.||HAVLICEK, Libor|
The present invention relates to novel 5-substituted-7-[4-(2-pyridyl) phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines of formula I which are potent inhibitors of protein kinases, especially cyclin- dependerit kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
WO/2016/180381 A SAFETY DEVICE FOR DETECTION OF A SECURELY CLOSED DOOR OF A DRUM OF A WASHING MACHINE||WO||17.11.2016|
||PCT/CZ2015/050008||ALLIANCE LAUNDRY CE S.R.O..||LECO, Tomas|
A safety device for detection of a securely closed door of a drum of a washing machine, wherein the safety device comprises a control unit, at least one electronic sensor (1) interconnected to the control unit, at least one magnetic unit (2) and at least one lock (3) of the door of the drum of the washing machine (4).
WO/2016/180382 IONIZING RADIATION DETECTOR MODULE||WO||17.11.2016|
||PCT/CZ2016/000054||ADVACAM s.r.o.||JAKŮBEK, Jan|
A module (1) for a detector (14) of ionizing radiation comprising at least two detection segments (2) for detecting ionizing radiation, attached to a row carrier (3) allowing for the assembly of detectors (14) with an unlimitedly large detection surface for continuous imaging of ionizing radiation. The construction of the module (1), including a means (10) for power supply stabilization for each detection segment (2), an interconnection of electrical conductors (8), formed by printed circuit boards (9, 13) led vertically downwards perpendicular to the detector surface along the row carrier (3), and a parallel connection to the connectors (11) of the read-out electronics, increases the reliability and speed of the operation of the detector (14). Between the individual parts of the module (1) there are formed thermal bridges to stabilize the temperature and to increase the reliability of the detector (14) assemblies from the modules (1).