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1. (WO2019048962) AQUEOUS ORAL CARE FLUORIDE TREATMENT COMPOSITIONS, AND METHODS
Nota: Texto obtenido mediante procedimiento automático de reconocimiento óptico de caracteres.
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What Is Claimed Is:

1. An aqueous oral care fluoride treatment composition comprising:

0.5 wt-% to 4.8 wt-% of a water-soluble cationic N-containing polymer;

a pharmaceutically acceptable buffer;

1.0 wt-% to 2.5 wt-% of sodium fluoride; and

at least 60 wt-% water;

wherein the weight percentages are based on the total weight of the aqueous composition.

2. The treatment composition of claim 1 wherein the water-soluble cationic N- containing polymer is present in an amount of 0.6 wt-% to 4.0 wt-%.

3. The treatment composition of claim 1 or 2 wherein the water-soluble cationic N- containing polymer is derived from a polymer precursor that is not cationic prior to incorporation into the treatment composition.

4. The treatment composition of any of the previous claims wherein the water-soluble N-containing polymer or polymer precursor is selected from a (meth)acrylate copolymer having dimethyiaminoelhyl side groups, a polyetbylenimine, a cationic-modified polysaccharide, and a combination thereof.

5. The treatment composition of claim 4 wherein the water-soluble cationic N- containin polymer or polymer precursor is selected from:


wherein n = 50-2000;


wherein x = 200-20,000, and y = 200-20,000;


wherein n = 5,000-1,000,000,


wherein n = 10-1,000;

and combinations of any of the above.

6. The treatment composition of any of the preceding claims further comprising a thickener.

7. The treatment composition of claim 6 wherein the thickener is present in an amount sufficient to provide the composition with a viscosity of 0.5 to 100 Pascal seconds at a shear rate of 1.0/second.

8. The treatment composition of claim 6 or 7 wherein the thickener is present in an amount of less than 2.5 wt-%.

9. The treatment composition of any of the preceding claims further comprising a calcium salt.

10. The treatment composition of any of the preceding claims which has a pH of 6 to 8.

1 1. The treatment composition of any of the preceding claims comprising less than 5 wt-% organic solvent.

12. The treatment composition of any of the preceding claims which releases at least 50% of the sodium fluoride in 5 minutes or less.

13. The treatment composition of any of the preceding claims which releases no greater than 90% of the sodium fluoride in 1 minute or less.

14, The treatment composition of any of the preceding claims which releases 100% of the sodium fluoride in 10 minutes or less.

15. The treatment composition of any of the preceding claims comprising up to 96 wt-% water,

16. A method of providing fluoride to a patient's tooth surface, the method comprising applying an aqueous oral care fluoride treatment composition of any of the preceding claims to the patient's tooth surface.

17, The method of claim 16 wherein applying comprises painting the treatment composition on the patient's tooth surface.

18. The method of claim 16 wherein applying comprises dispensing the treatment composition into a dental tray and attaching the tray having the treatment composition therein to the patient's tooth surface.

19. The method of claim 18 wherein the dental tray comprises an orthodontic aligner treatment tray.

20. A method of reducing the incidence of dental caries in a patient in need thereof, the method comprising applying an aqueous oral care fluoride treatment composition of any one of claims 1 through 16 to the patient's tooth surface.